The Measurement of Recessive Lethal Mutations in the Mouse

  • William Sheridan


In the early 1950s concern began to develop among geneticists for the potential genetic risks to humans from ionizing irradiation. Although the mutagenic effects of X-rays had been known and studied since the 1920s, the advent of the use of atomic energy in warfare and the increasing use of sources of irradiation in industry and medicine expanded the possibilities of accidental or intentional exposures of humans.


Litter Size Inbred Strain Fetal Mortality Chronic Irradiation Female Germ Cell 
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  1. 1.
    W. L. Russell, Genetic effects of radiation in mammals, Radiat. Biol. 1, 825–859 (1954).Google Scholar
  2. 2.
    J. B. S. Haldane, The detection of autosomal lethals in mice by mutagenic agents, J. Genet. 54, 327–342 (1956).CrossRefGoogle Scholar
  3. 3.
    T. C. Carter, A pilot experiment with mice, using Haldane’s method for detecting induced autosomal recessive lethal genes, J. Genet. 56, 353–362 (1959).CrossRefGoogle Scholar
  4. 4.
    T. Sugahara, Y. Okazawa, K. Tutikawa, and S. Muramatsu, Recessive lethal mutations in mice induced by chronic irradiation given during the whole reproductive period through three successive generations, Jpn. J. Genet. (Suppl.) 36, 31–41 (1961).Google Scholar
  5. 5.
    S. Muramatsu, T. Sugahara, and Y. Okazawa, Genetic effects of chronic low-dose irradiation on mice, Int. J. Radiat. Biol. 6(1), 49–59 (1963).CrossRefGoogle Scholar
  6. 6.
    T. Sugahara, Genetic effects of chronic irradiation given to mice through three successive generations, Genetics 50, 1143–1158 (1964).Google Scholar
  7. 7.
    T. C. Carter, Recessive lethal mutation induced in the mouse by chronic 7-irradiation, Proc. R. Soc. B. 147, 402–411 (1957).CrossRefGoogle Scholar
  8. 8.
    T. C. Carter and M. F. Lyon, An attempt to estimate the induction by X-rays of recessive lethal and visible mutations in mice, Genet. Res. 2, 296–305 (1961).CrossRefGoogle Scholar
  9. 9.
    M. F. Lyon, R. J. S. Phillips, and A. G. Searle, The overall rates of dominant and recessive lethal and visible mutation induced by spermatogonial X-irradiation of mice, Genet. Res. 5, 448–467 (1964).CrossRefGoogle Scholar
  10. 10.
    K. G. Liming, W. Sheridan, and H. Frölën, Genetic effects of supra-lethal X-ray treatment of male mice, Mutat. Res. 2, 60–66 (1965).CrossRefGoogle Scholar
  11. 11.
    W. Sheridan, The effects of acute single or fractionated X-ray treatment on mouse spermatogonia, Mutat. Res. 5, 163–172 (1968).CrossRefGoogle Scholar
  12. 12.
    K. G. Liming, W. Sheridan, K. H. Ytterborn, and U. Gullberg, The relationship between the number of implantations and the rate of intra-uterine death in mice, Mutat. Res. 3, 444–451 (1966).CrossRefGoogle Scholar
  13. 13.
    W. Sheridan, The radiosensitivity of offspring of an irradiated mouse population, I. Effects on the reproductive capacity of irradiated female offspring, Mutat. Res. 4, 675–681 (1967).CrossRefGoogle Scholar
  14. 14.
    W. Sheridan, The effects of the time interval in fractionated X-ray treatment of mouse spermatogonia, Mutat. Res. 13, 163–169 (1971).CrossRefGoogle Scholar
  15. 15.
    H. W. Michelmann and W. Sheridan, Effects of transmitted translocations in mice, in: Abstracts of 9th Annual Meeting of Environmental Mutagen Society, p. 47 (1978).Google Scholar
  16. 16.
    W. Sheridan, The induction by X-irradiation of dominant lethal mutations in spermatogonia of mice, Mutat. Res. 2, 67–74 (1965).CrossRefGoogle Scholar
  17. 17.
    K. G. Liming, Test of recessive lethals in the mouse, Mutat. Res. 27, 357–366 (1975).CrossRefGoogle Scholar
  18. 18.
    M. A. Hamilton and J. K. Haseman, Statistical tests for recessive lethal-carriers, Mutat. Res. 64, 269–278 (1979).Google Scholar
  19. 19.
    M. F. Lyon, Some evidence concerning the “mutational load” in inbred strains of mice, Heredity 13, 341–352 (1959).CrossRefGoogle Scholar
  20. 20.
    K. G. Liming, Spontaneous recessive lethal mutations in the mouse, Mutat. Res. 27, 367–373 (1975).CrossRefGoogle Scholar
  21. 21.
    K. G. Liming and A. G. Searle, Estimates of the genetic risks from ionizing irradiation, Mutat. Res. 12, 291–304 (1971).CrossRefGoogle Scholar
  22. 22.
    N. Ryman, The frequency of recessive lethal heterozygotes among individuals obtained from inbred strains. A random-number simulation study, Mutat. Res. 42, 363–372 (1977).CrossRefGoogle Scholar
  23. 23.
    K. G. Liming, Testing for recessive lethals in mice, Mutat. Res. 11, 125–132 (1971).CrossRefGoogle Scholar
  24. 24.
    A. G. Searle, Effects of low-level irradiation on fitness and skeletal variation in an inbred mouse strain, Genetics 50, 1159–1178 (1964).Google Scholar
  25. 25.
    K. G. Liming, C. Rönnbäck, and W. Sheridan, Genetic effects of acute and chronic irradiation with 14 MeV neutrons, Ada Radiol. 14, 401–416 (1975).Google Scholar
  26. 26.
    A. G. Searle and R. J. S. Phillips, Genetic effects of neutron irradiation in mice, in: Biological Effects of Neutron and Proton Irradiations (P. I. Smirnov, ed.), Vol. 1, pp. 361–370, IAEA, Vienna (1964).Google Scholar
  27. 27.
    K. G. Liming and A. Eiche, X-ray induced recessive lethal mutations in the mouse, Mutat. Res. 34, 163–174 (1975).Google Scholar
  28. 28.
    M. D. Pomerantseva, L. K. Ramaiya, and G. A. Vilkina, Mutagenic effect of various types of radiation in the germ cells of male mice, X. Frequency of recessive lethal mutations and reciprocal translocations in the spermatogonia of mice subjected to fractionated gamma irradiation, Sov. Genet. 12(7), 816–823 (1976).Google Scholar
  29. 29.
    K. G. Liming, Studies of irradiated mouse populations, I. Plans and report of the 1st generation, Hereditas 46, 668–674 (1960).CrossRefGoogle Scholar
  30. 30.
    K. G. Liming, Studies of irradiated mouse populations, II. Dominant effects on productivity in the 4th-6th generation, Hereditas 50, 361–376 (1963).CrossRefGoogle Scholar
  31. 31.
    K. G. Liming, Studies of irradiated mouse populations, III. Accumulation of recessive lethals, Mutat. Res. 1, 86–98 (1964).CrossRefGoogle Scholar
  32. 32.
    K. G. Liming, Studies of irradiated mouse populations, IV. Effects on productivity in the 7th-18th generations, Mutat. Res. 14, 331–344 (1972).CrossRefGoogle Scholar
  33. 33.
    W. Sheridan and I. Wårdell, the frequency of recessive lethals in an irradiated mouse population, Mutat. Res. 5, 313–321 (1968).CrossRefGoogle Scholar
  34. 34.
    C. Rönnbäck, Dominant and recessive effects of induced lethals in female mice by exposure to gamma-irradiation during the 10th to 14th day of intrauterine life, Mutat. Res. 49, 61–70 (1978).CrossRefGoogle Scholar
  35. 35.
    C. Rönnbäck and W. Sheridan, Induction of lethal mutations in female mice by 9 generations of 7-irradiation during foetal development, Mutat. Res. 61, 275–285 (1979).CrossRefGoogle Scholar
  36. 36.
    W. Sheridan, Detection of induced recessive lethal mutations in mice, Environ. Health Perspect. 33, 331 (1979).Google Scholar
  37. 37.
    E. R. Soares and W. Sheridan, Triethylenemelamine induced dominant lethals in mice—Comparisons of oral versus intraperitoneal injection, Mutat. Res. 43, 247–254 (1977).CrossRefGoogle Scholar
  38. 38.
    K. Biirki and W. Sheridan, Expression of TEM-induced damage to postmeiotic stages of spermatogenesis of the mouse during early embryogenesis, I. Investigations with in vitro embryo culture, Mutat. Res. 49, 259–268 (1978).CrossRefGoogle Scholar
  39. 39.
    K. Biirki and W. Sheridan, Expression of TEM-induced damage to postmeiotic stages of spermatogenesis of the mouse during early embryogenesis, II. Cytological investigations, Mutat. Res. 52, 107–115 (1978).CrossRefGoogle Scholar
  40. 40.
    E. R. Soares, W. Sheridan, J. K. Haseman, and M. Segall, Increased frequencies of aberrant sperm as indicators of mutagenic damage in mice, Mutat. Res. 64, 27–35 (1979).Google Scholar
  41. 41.
    W. Sheridan, The dominant effects of a recessive lethal in the mouse, Mutat. Res. 5, 323–328 (1968).CrossRefGoogle Scholar
  42. 42.
    K. G. Liming and W. Sheridan, Dominant effects on productivity in offspring of irradiated mouse populations, Genetics 50, 1043–1052 (1964).Google Scholar
  43. 43.
    K. G. Liming and W. Sheridan, Do recessive lethals have dominant deleterious effects in mice?, Mutat. Res. 3, 340–345 (1966).CrossRefGoogle Scholar
  44. 44.
    K. G. Liming and W. Sheridan, Dominant effects of recessive lethals in mice, Hereditas 59, 289–297 (1968).CrossRefGoogle Scholar
  45. 45.
    K. G. Liming, Dominant effects of recessive lethals in mice, II. Viability and mating ability, Mutat. Res. 8, 573–580 (1969).CrossRefGoogle Scholar
  46. 46.
    K. G. Liming, Analysis of the dominance effect of a spontaneous recessive lethal in the mouse on homozygous and heterozygous genetic background, Mutat. Res. 27, 257–260 (1975).CrossRefGoogle Scholar
  47. 47.
    United Nations Scientific Committee on the Effects of Atomic Radiation, Sources and Effects of Ionizing Radiation, United Nations, New York (1977).Google Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • William Sheridan
    • 1
  1. 1.National Institute of Environmental Health SciencesResearch Triangle ParkUSA

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