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Effects of UV Radiation on Immune Responses in Animals

  • Chapter
Photoimmunology

Abstract

There are several immune responses in which the skin serves at the route of entry for the foreign material (antigen) or as the site at which an immunologic reaction occurs. These immune responses, which include delayed-type (lymphocyte-mediated) hypersensitivity, contact hypersensitivity (CHS) (also called allergic contact dermatitis), skin graft rejection, and some forms of immediate (antibody-mediated) hypersensitivity, historically have held a prominent place in dermatologic research. Since exposure to sunlight has been noted clinically both to exacerbate and ameliorate certain cutaneous reactions, it is not surprising that experimental studies were initiated to examine the effects of UV radiation on the elicitation of immune reactions in the skin.

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References

  1. Elihilali MM, Brosman SA, Vescera C, et al: The effects of treatment on delayed cutaneous hypersensitivity responses (DNCB, Croton oil, and recall antigen) in patients with genitourinary cancer. Cancer 41:1765–1770, 1978.

    Article  Google Scholar 

  2. Byers VS, Epstein WL, Castagnoli N, et al: In vitro studies of poison oak immunity. I. In vitro reaction of human lymphocytes to urushiol. J Clin Invest 64:1437–1448, 1979.

    Article  PubMed  CAS  Google Scholar 

  3. Frei W: Uber willkurliche Sensibilisierung gegen chemisch-definierte Substanzen; Un-tersuchungen mit Neosalvarsan am Menschen. Klin Wochenschr 7:539–542, 1928.

    Article  CAS  Google Scholar 

  4. Sulzberger MB: Hypersensitiveness to arsphenamine in guinea pigs; experiments in prevention and in desensitization. Arch DermatolSymp 20:699–697, 1929.

    Google Scholar 

  5. Landsteiner K, Chase MW: Experiments on transfer of cutaneous sensitivity to simple compounds. Proc Soc Exp Biol Med 49:688–690, 1942.

    CAS  Google Scholar 

  6. Shelmire JB: Contact dermatitis from weeds: Patch testing with their oleoresins. JAMA 113:1085–1090, 1939.

    Google Scholar 

  7. Chase MW: Inhibition of experimental drug allergy by prior feeding of the sensitizing agent. Proc Soc Exp Biol Med 61:257–259, 1946.

    PubMed  CAS  Google Scholar 

  8. Frey JR, Wenk P: Experimental studies on the pathogenesis of contact eczema in guinea pigs. Int Arch Allergy Appl Immunol 11:81–100, 1957.

    Article  PubMed  CAS  Google Scholar 

  9. Macher E, Chase MW: Studies on sensitization of animals with simple chemical compounds. XII. The influence of excision of allergenic depots on onset of delayed hypersensitivity and tolerance. J Exp Med 129:103–121, 1969.

    Article  PubMed  CAS  Google Scholar 

  10. Lowney ED: Attenuation of contact sensitization in man. J Invest Dermatol 50:244–249, 1968.

    PubMed  CAS  Google Scholar 

  11. Lowney ED: Immunologic unresponsiveness to a contact sensitizer in man. J Invest Dermatol 51:411–417, 1968.

    PubMed  CAS  Google Scholar 

  12. Asherson GL, Zembala M, Perera MACC, et al: Production of immunity and unresponsiveness in the mouse by feeding contact-sensitizing agents and the role of suppressor cells in the Peyer’s patches, mesenteric lymph nodes and other lymphoid tissues. Cell Immunol 33:145–155, 1977.

    Article  PubMed  CAS  Google Scholar 

  13. Vadas MA, Miller JFAP, Gamble J, et al: A radioisotopic method to measure delayed type hypersensitivity in the mouse. 1. Studies in sensitized and normal mice. Int Arch Allergy Appl Immunol 49:670–692, 1975.

    Article  PubMed  CAS  Google Scholar 

  14. Miller JFAP, Vadas MA, Whitelaw A, et al: A radioisotopic method to measure delayed type hypersensitivity in the mouse. II. Cell transfer studies. Int Arch Allergy Appl Immunol 49:693–708, 1975.

    Article  PubMed  CAS  Google Scholar 

  15. Polak L, Geleick H, Turk JL: Reversal by cyclophosphamide of tolerance in contact sensitization. Tolerance induced by prior feeding with DNCB. Immunology 28:939–942, 1975.

    PubMed  CAS  Google Scholar 

  16. Sy MS, Dietz MH, Germain RN, et al: Antigen- and receptor-driven regulatory mechanisms: IV. Idiotype-bearing I-J suppressor T cell factors induce second-order suppressor T cells which express anti-idiotype receptors. J Exp Med 151:1183–1195, 1980.

    Article  PubMed  CAS  Google Scholar 

  17. Miller SD, Butler LD, Claman HN: Suppressor T cell circuits in contact sensitivity. I. Two mechanistically distinct waves of suppressor T cells occur in mice tolerized with syngeneic DNP-modified lymphoid cells. J Immunol 129:461–468, 1982.

    PubMed  CAS  Google Scholar 

  18. Thomas DW, Forni G, Shevach EM, et al: The role of the macrophage as the stimulator cell in contact sensitivity. J Immunol 118:1677–1681, 1977.

    PubMed  CAS  Google Scholar 

  19. Unanue ER: The regulatory role of macrophages in antigenic stimulation. Adv Immunol 31:1–36, 1981.

    Article  PubMed  CAS  Google Scholar 

  20. Steinman RM, Kaplan G, Witmer M, et al: Identification of a novel cell-type in peripheral lymphoid organs of mice. V. Purification of spleen dendritic cells, new surface markers, and maintenance in vitro. J Exp Med 149:1–16, 1979.

    Article  PubMed  CAS  Google Scholar 

  21. Steinman RM, Witmer M: Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice. Proc Natl Acad Sci USA 75:5132–5136, 1978.

    Article  PubMed  CAS  Google Scholar 

  22. Nussenzweig MC, Steinman RM, Unkeless JC, et al: Studies of the cell surface of mouse dendritic cells and other leukocytes. J Exp Med 154:168–187, 1981.

    Article  PubMed  CAS  Google Scholar 

  23. Nussenzweig MC, Steinman RM: Contribution of dendritic cells to stimulation of the murine syngeneic mixed leukocyte reaction. J Exp Med 151:1196–1212, 1980.

    Article  PubMed  CAS  Google Scholar 

  24. Silberberg I: Apposition of mononuclear cells to Langerhans cells in contact allergic reactions. An ultrastructural study. Acta Derma Venerol 51:1–12, 1973.

    Google Scholar 

  25. Silberberg-Sinakin I, Baer RL, Thorbecke GJ: Langerhans cells. A review of their nature with emphasis on their immunologic functions. Prog Allergy 24:268–294, 1978.

    PubMed  CAS  Google Scholar 

  26. Silberberg-Sinakin I, Thorbecke GJ, Baer RL, et al: Antigen-bearing Langerhans cells in skin, dermal lymphatics and in lymph nodes. Cell Immunol 25:137–151, 1976.

    Article  PubMed  CAS  Google Scholar 

  27. Wolff K, Schreiner E: Uptake, intracellular transport and degradation of exogeneous protein by Langerhans cells. J Invest Dermatol 54:37–47, 1970.

    Article  PubMed  CAS  Google Scholar 

  28. Shelley WB, Juhlin L: Langerhans cells form a reticuloepithelial trap for external contact antigens. Nature 261:46–47, 1976.

    Article  PubMed  CAS  Google Scholar 

  29. Stingl G, Wolff-Schreiner EC, Pichler WJ, et al: Epidermal Langerhans cells bear Fc and C3 receptors. Nature 268:245–246, 1977.

    Article  PubMed  CAS  Google Scholar 

  30. Rowden G, Lewis MG, Sullivan AK: la antigen expression on human epidermal Langerhans cells. Nature 268:247–248, 1977.

    Article  PubMed  CAS  Google Scholar 

  31. Klareskog L, Malmnas-Tjernlund U, Forsum U, et al: Epidermal Langerhans cells express la antigens. Nature 268:248–250, 1970.

    Article  Google Scholar 

  32. Stingl G, Katz SI, Abelson LD, et al: Immunofluorescent detection of human B cell alloantigens on S-Ig-positive lymphocytes and epidermal Langerhans cells. J Immunol 120:661–664, 1978.

    PubMed  CAS  Google Scholar 

  33. Rowden G, Phillips TM, Delovitch TL: Visualization of la antigen localization in murine keratinizing epithelia. Immunogenetics 7:465–478, 1978.

    Article  PubMed  CAS  Google Scholar 

  34. Stingl G, Katz SI, Shevach EM, et al: Detection of la antigens on Langerhans cells in guinea pig skin. J Immunol 120:570–578, 1978.

    PubMed  CAS  Google Scholar 

  35. Hammerling GJ, Mauve G, Goldberg E, et al: Tissue distribution of la antigens: la on spermatozoa, macrophages and epidermal cells: Immunogenetics 1:428–437, 1975.

    Article  Google Scholar 

  36. Klein J, Geib R, Chiang C, et al: Histocompatibility antigens controlled by the I region of the murine H-2 complex. I. Mapping of H-2A and H-2C loci. J Exp Med 143:1439–1452, 1976.

    Article  PubMed  CAS  Google Scholar 

  37. Krco FJ, Steinmuller D, David CS: Expression of I-region gene products on mouse tail epidermis cells. Cell Immunol 46:239–246, 1979.

    Article  PubMed  CAS  Google Scholar 

  38. Lampert IA, Suitters AJ, Chisolm PM: Expression of la antigen on epidermal kerotinocytes in graft vs host disease. Nature 293:149–151, 1981.

    Article  PubMed  CAS  Google Scholar 

  39. Frelinger JG, Hood L, Hills S, et al: Mouse epidermal la molecules have a bone marrow origin. Nature 282:321–323, 1979.

    Article  PubMed  CAS  Google Scholar 

  40. Katz SI, Tamaki K, Sachs DH: Epidermal Langerhans cells are derived from cells originating in the bone marrow. Nature 282:324–326, 1979.

    Article  PubMed  CAS  Google Scholar 

  41. Toews GB, Bergstresser PR, Streilein JW: Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB. J Immunol 124:445–453, 1980.

    PubMed  CAS  Google Scholar 

  42. Semma W, Sagami S: Induction of suppressor T cells to DNFB contact sensitivity by application of sensitizer through Langerhans cell-deficient skin. Arch Dermatol Res 271:361–364, 1981.

    Article  PubMed  CAS  Google Scholar 

  43. Streilein JW, Sullivan S, Thompson S: Contact hypersensitivity, humoral immunity, and specific unresponsiveness can be induced in Syrian hamsters with simple haptens. J Immunol 124:577–585, 1980.

    PubMed  CAS  Google Scholar 

  44. Bergstresser PR, Fletcher CR, Streilein JW: Surface densities of Langerhans cells in relation to rodent epidermal sites with special immunological properties. J Invest Dermatol 74:77–80, 1980.

    Article  PubMed  CAS  Google Scholar 

  45. Streilein JW, Bergstresser PR: Langerhans cell function dictates induction of contact hypersensitivity or unresponsiveness to DNFB in Syrian hamsters. J Invest Dermatol 77:272–277, 1981.

    Article  PubMed  CAS  Google Scholar 

  46. Stingl G, Katz SI, Clement L, et al: Immunologic functions of la-bearing epidermal Langerhans cells. J Immunol 121:2005–2013, 1978.

    CAS  Google Scholar 

  47. Stingl G, Gazze-Stingl LA, Aberer W, et al: Antigen presentation by murine epidermal cells and its alteration by ultraviolet B light. J Immunol 127:1707–1713, 1981.

    PubMed  CAS  Google Scholar 

  48. Stingl G, Katz SI, Shevach EM, et al: Analogous functions of macrophages and Langerhans cells in the initiation of the immune response. J Invest Dermatol 71:59–64, 1978.

    Article  PubMed  CAS  Google Scholar 

  49. Stingl G, Tamaki K, Katz SI: Origin and function of epidermal Langerhans cells. Immunol Rev 53:149–174, 1980.

    Article  PubMed  CAS  Google Scholar 

  50. Greene MI, Sugimoto M, Benacerraf B: Mechanisms of regulation of cell-mediated immune responses. I. Effect of route of immunization with TNP-coupled syngeneic cells on the induction and suppression of contact sensitivity to picrylchloride. J Immunol 120:1604–1611, 1978.

    PubMed  CAS  Google Scholar 

  51. Ptak W, Rozycka D, Askenase PW, et al: Role of antigen-presenting cells in the development and persistence of contact hypersensitivity. J Exp Med 151:362–375, 1980.

    Article  PubMed  CAS  Google Scholar 

  52. Tamaki K, Fujiwara H, Katz SI: The role of epidermal cells in the induction and suppression of contact sensitivity. J Invest Dermatol 76:275–278, 1981.

    Article  PubMed  CAS  Google Scholar 

  53. Haniszko J, Suskind RR: The effect of ultraviolet radiation on experimental cutaneous sensitization in guinea pigs. J Invest Dermatol 40:183–191, 1963.

    PubMed  CAS  Google Scholar 

  54. Morison WL, Parrish JA, Woehler ME, et al: The influence of ultraviolet radiation on allergic contact dermatitis in the guinea pig. I. UVB radiation. Br J Dermatol 104: 161–164, 1981.

    Article  PubMed  CAS  Google Scholar 

  55. Meyer J Ch, Grundmann H-P, Weiss H: Inhibitory effect of 8-methoxypsoralen plus UVA (PUVA) on the systemic induction of contact sensitivity to dinitrochlorobenzene (DNCB) in guinea pigs. Arch Dermatol Res 269:189–195, 1980.

    Article  PubMed  CAS  Google Scholar 

  56. Lynch DH, Gurish MF, Daynes RA: Relationship between epidermal Langerhans cell density, ATPase activity, and the induction of contact hypersensitivity. J Immunol 126:1891–1897, 1981.

    Google Scholar 

  57. Noonan F, De Fabo E, Kripke ML: Suppression of contact hypersensitivity by ultraviolet radiation: An experimental model. Springer Sem Immunopathol 4:293–304, 1981.

    Article  CAS  Google Scholar 

  58. Jessup JM, Hanna N, Palaszynski E, et al: Mechanisms of depressed reactivity to dinitrochlorobenzene and ultraviolet-induced tumors during ultraviolet carcinogenesis in BALB/c mice. Cell Immunol 38:105–115, 1978.

    Article  PubMed  CAS  Google Scholar 

  59. Kripke ML, Lofgreen JS, Beard J, et al: In vivo immune responses of mice during carcinogenesis by ultraviolet radiation. J Natl Cancer Inst 59:1227–1230, 1977.

    PubMed  CAS  Google Scholar 

  60. Noonan FP, Kripke ML, Pedersen GM, et al: Suppression of contact hypersensitivity in mice by ultraviolet radiation is associated with defective antigen presentation. Immunology 43:527–533, 1981.

    PubMed  CAS  Google Scholar 

  61. Noonan FP, De Fabo EC, Kripke ML: Suppression of contact hypersensitivity by UV radiation and its relationship to UV-induced suppression of tumor immunity. Photochem Photobiol 34:683–689, 1981.

    PubMed  CAS  Google Scholar 

  62. De Fabo EC, Noonan FP, Kripke ML: An in vivo action spectrum for ultraviolet radiation-induced suppression of contact sensitivity in BALB/c mice. Am Soc Photobiol, Vol 9, p 185, 1981 (Abstr).

    Google Scholar 

  63. Kripke ML: Immunosuppressive effects of ultraviolet (280–320 nm) radiation and psoralen plus ultraviolet (320–400 nm) radiation in mice. J Natl Cancer Inst 69:171–173, 1982.

    PubMed  CAS  Google Scholar 

  64. Fan J, Schoenfeld RJ, Hunter R: A study of the epidermal clear cells with special reference to their relationship to the cells of Langerhans. J Invest Dermatol 32:445–449, 1959.

    Article  PubMed  CAS  Google Scholar 

  65. Zelickson AS, Mottaz J: The effects of sunlight on human epidermis. Arch Dermatol 101:312–315, 1970.

    Article  PubMed  CAS  Google Scholar 

  66. Wolff K, Winkelmann RK: The influence of ultraviolet light on the Langerhans cell population and its hydrolytic enzymes in guinea pigs. J Invest Dermatol 48:531–539, 1967.

    PubMed  CAS  Google Scholar 

  67. Aberer W, Schuler G, Stingl G, et al: Ultraviolet light depletes surface markers of Langerhans cells. J Invest Dermatol 76:202–210, 1981.

    Article  PubMed  CAS  Google Scholar 

  68. Norlund JJ, Ackles AE, Lerner AB: The effects of ultraviolet light and certain drugs on la-bearing Langerhans cells in murine epidermis. Cell Immunol 60:50–63, 1981.

    Article  Google Scholar 

  69. Okamoto H, Horio T: The effects of 8-methoxypsoralen and longwave ultraviolet light on Langerhans cells. J Invest Dermatol 77:345–346, 1981.

    Article  PubMed  CAS  Google Scholar 

  70. Streilein JW, Toews GB, Bergstresser PR: Functional aspects of Langerhans cells revealed by in vivo grafting studies. J Invest Dermatol 75:17–21, 1980.

    Article  PubMed  CAS  Google Scholar 

  71. Sauder DN, Tamaki K, Moshell AN, et al: Induction of tolerance to topically applied TNCB using TNP-conjugated ultraviolet light-irradiated epidermal cells. J Immunol 127:261–265, 1981.

    PubMed  CAS  Google Scholar 

  72. Luger TA, Stadler BM, Katz SI, et al: Epidermal cell (keratinocyte)-derived thymocyte- activating factor (ETAF). J Immunol 127:1493–1498, 1981.

    PubMed  CAS  Google Scholar 

  73. Noonan FP, Bucana C, Sauder DN, et al: Effect of UV radiation on epidermal Langerhans cell morphology and function: a dichotomy. J Invest Dermatol (Abstr.) 78:345, 1982.

    Google Scholar 

  74. Lindahl-Kiessling K, Safwenberg J: Inability of UV-irradiated lymphocytes to stimulate allogeneic cells in mixed lymphocyte culture. Int Arch Allergy Appl Immunol 41:670–678, 1971.

    Article  PubMed  CAS  Google Scholar 

  75. Lafferty KJ, Misko IS, Cooley MA: Allogeneic stimulation modulates the in vitro response of T cells to transportation antigen. Nature 249:275–276, 1974.

    Article  PubMed  CAS  Google Scholar 

  76. Rollinghoff M, Wagner H: Secondary cytotoxic allograft response in vitro. I. Antigenic requirements. Eur J Immunol 5:875–879, 1975.

    Article  Google Scholar 

  77. Wagner H, Rollinghoff M: Secondary allograft responses in vitro. II. Differentiation of memory T cells into cytotoxic T lymphocytes in the absence of cell proliferation. Eur J Immunol 6:15–21, 1976.

    Article  PubMed  CAS  Google Scholar 

  78. Grillot-Curvalin C, Alter BJ, Bach FH: Antigenic requirements for the generation of secondary cytotoxicity. J Immunol 119:1253–1259, 1977.

    Google Scholar 

  79. Slater LM, Murray S, Liu J, et al: Dissimilar effects of ultraviolet light on HLA-D and HLA-DR antigens. Tissue Antigens 15:431–435, 1980.

    Article  PubMed  CAS  Google Scholar 

  80. Greene MI, Sy MS, Kripke M, et al: Impairment of antigen-presenting cell function by ultraviolet light. Proc Natl Acad Sci USA 76:6591–6595, 1979.

    Article  PubMed  CAS  Google Scholar 

  81. Letvin NL, Greene MI, Benacerraf B, et al: Immunologic effects of whole-body ultraviolet irradiation: Selective defect in splenic adherent cell function in vitro. Proc Natl Acad Sci USA 77:2881–2885, 1980.

    Article  PubMed  CAS  Google Scholar 

  82. Fox IJ, Sy MS, Benacerraf B, et al: Impairment of antigen-presenting cell function by ultraviolet radiation. II. Effect of in vitro ultraviolet irradiation on antigen-presenting cells. Transplantation 31:262–265, 1981.

    Article  PubMed  CAS  Google Scholar 

  83. Fox IJ, Perry LL, Sy MS, et al: The influence of ultraviolet light irradiation on the murine system. Clin Immunol Immunopathol 17:141–155, 1980.

    Article  PubMed  CAS  Google Scholar 

  84. Letvin NL, Nepom JT, Greene MI, et al: Loss of la-bearing splenic adherent cells after whole body ultraviolet irradiation. J Immunol 125:2550–2554, 1980.

    PubMed  CAS  Google Scholar 

  85. Kripke ML, Fisher MS: Immunologic parameters of ultraviolet carcinogenesis. J Natl Cancer Inst 57:211–215, 1976.

    PubMed  CAS  Google Scholar 

  86. Kripke ML, Thorn RM, Lill PH, et al: Further characterization of immunologic unresponsiveness induced in mice by UV radiation: Growth and induction of non-UV- induced tumors in UV-irradiated mice. Transplantation 28:212–217, 1979.

    Article  PubMed  CAS  Google Scholar 

  87. Fisher MS, Kripke ML: Systemic alteration induced in mice by ultraviolet light irradiation and its relationship to ultraviolet carcinogenesis. Proc Natl Acad Sci USA 74: 1688–1692, 1977.

    Article  PubMed  CAS  Google Scholar 

  88. Fisher MS, Kripke ML: Further studies on the tumor-specific suppressor cells induced by ultraviolet radiation. J Immunol 121:1139–1144, 1978.

    PubMed  CAS  Google Scholar 

  89. Daynes RA, Spellman CW: Evidence for the generation of suppressor cells by ultraviolet radiation. Cell Immunol 31:182–187, 1977.

    Article  PubMed  CAS  Google Scholar 

  90. Thorn RT, Fisher MS, Kripke ML: Further characterization of immunological unresponsiveness induced in mice by ultraviolet radiation. II. Studies on the origin and activity of ultraviolet-induced suppressor lymphocytes. Transplanatation 31:129–133, 1981.

    Article  CAS  Google Scholar 

  91. Spellman CW, Woodward JG, Daynes RA: Modification of immunologic potential by ultraviolet radiation. I. Immune status of short-term UV-irradiated mice. Transplantation 24:112–119, 1977.

    Article  PubMed  CAS  Google Scholar 

  92. Fortner GW, Kripke ML: In vitro reactivity of splenic lymphocytes from normal and UV-irradiated mice against syngeneic UV-induced tumors. J Immunol 118:1483–1487, 1977.

    PubMed  CAS  Google Scholar 

  93. Thorn RT: Specific inhibition of cytotoxic memory cells produced against UV-induced tumors in UV-irradiated mict. J Immunol 121:1920–1926, 1978.

    PubMed  CAS  Google Scholar 

  94. Morison WL, Parrish JA, Woehler ME, et al: The influence of PUVA and UVB radiation on skin-graft survival in rabbits. J Invest Dermatol 75:331–333, 1980.

    Article  PubMed  CAS  Google Scholar 

  95. Kripke ML, Morison WL, Parrish JA: Induction and transplantation of murine skin cancers induced by methoxsalen plus ultraviolet (320–400 nm) radiation. J Natl Cancer Inst 68:685–690, 1982.

    PubMed  CAS  Google Scholar 

  96. Roberts LK, Schmitt M, Daynes RA: Tumor susceptibility generated in mice treated with subcarcinogenic doses of 8-methoxypsoralen and long-wave ultraviolet light. J Invest Dermatol 72:306–309, 1979.

    Article  PubMed  CAS  Google Scholar 

  97. Kripke ML, Morison WL, Parrish JA: Differences in the immunologic reactivity of mice treated with UVB or methoxsalen plus UVA radiation. J Invest Dermatol 76: 445–448, 1981.

    Article  PubMed  CAS  Google Scholar 

  98. Kripke ML: Immunologic mechanisms in UV radiation carcinogenesis. Adv Cancer Res 34:69–106, 1981.

    Article  PubMed  CAS  Google Scholar 

  99. Morison WL, Parrish JA, Woehler ME, et al: Influence of PUVA and UVB radiation on delayed hypersensitivity in the guinea pig. J Invest Dermatol 76:484–488, 1981.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Departments of Dennatology and Internal Medicine, Southwestern Medical School, University of Texas Health Science Center, Dallas, Texas, 75235, USA

    Paul R. Bergstresser

  2. Departments of Cell Biology and Internal Medicine, Southwestern Medical School, University of Texas Health Science Center, Dallas, Texas, 75235, USA

    J. Wayne Streilein

  3. Basic Research Program-LBI, Frederick Cancer Research Facility, Frederick, Maryland, 21701, USA

    Margaret L. Kripke

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  1. Paul R. Bergstresser
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  2. J. Wayne Streilein
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  3. Margaret L. Kripke
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Editors and Affiliations

  1. Massachusetts General Hospital, Boston, Massachusetts, USA

    John A. Parrish

  2. Frederick Cancer Research Facility, Frederick, Maryland, USA

    Margaret L. Kripke  & Warwick L. Morison  & 

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© 1983 Plenum Publishing Corporation

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Bergstresser, P.R., Streilein, J.W., Kripke, M.L. (1983). Effects of UV Radiation on Immune Responses in Animals. In: Parrish, J.A., Kripke, M.L., Morison, W.L. (eds) Photoimmunology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3670-9_9

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  • DOI: https://doi.org/10.1007/978-1-4613-3670-9_9

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