Abstract
Few tissues or organ systems are as complex as the immune system, except perhaps the nervous system. Eighty years ago, when the immune response was first described, investigators naively thought that the immune response of an organism to exogenous antigen was a unitary, if mysterious, process that equipped the individual to nullify once and forever the pathogenic potential of specific invading microorganisms. Now, as we proceed through the second “Golden Age of Immunology,” we know that the immune response is heterogenous and that it is comprised of effector mechanisms that are both molecular and cellular. Moreover, we know that specific immune responses to exogenous antigens are associated with specific tissues and organs. Thus, antigens that gain access to the body through the oral route confront the immunologic apparatus initially through the gut and elicit a relatively unique immune response at mucous membrane surfaces of the gut and perhaps of the respiratory tract. In fact, immune responses elicited by antigens within one tissue may be deleterious to the host when these antigens are encountered at or through a different, unrelated tissue or organ. Thus, the immune system appears to be comprised of subsystems, regional spheres of influence, in which a specific tissue, its constituent (sessile) cells, and complementary immunocompetent (mobile) lymphocytes are integrated into an internally consistent response to antigen. Blood-borne effector cells generated in these regional spheres can circulate to other tissues and express themselves inappropriately in the new territory. In this chapter, we will discuss the unique regional sphere of immunologic influence of the skin, which is comprised of sessile cells, mobile cells, and regional draining lymph nodes that have been designated as skin-associated lymphoid tissues (SALT).
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Streilein, J.W., Tigelaar, R.E. (1983). SALT: Skin-Associated Lymphoid Tissues. In: Parrish, J.A., Kripke, M.L., Morison, W.L. (eds) Photoimmunology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3670-9_6
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