Abstract
The search for a cogent, unifying mechanism that can be invoked to explain the multiple actions of ethanol and of other related alcohols on the physiology, biochemistry, and behavior of organisms has been pursued for many years. Multiple attempts have been made to link the development of ethanol-induced intoxication and neurological changes as well as damage to other organs to altered metabolic states of various organs following acute or chronic ethanol intake. The many changes in liver, heart, kidney, and brain metabolism caused by acute and chronic ethanol intake have been reviewed thoroughly (Hawkins and Kalant 1972; Lieber, 1979; Wallgren, 1971). The general conclusion reached from such studies is that acute and chronic ethanol intake leads to changes in lipid and carbohydrate metabolism in liver and other organs (Cherrick and Leevy, 1965; Maling et al., 1967; Lieber, 1979), that it decreases protein release from livercells and may also affect protein synthesis and degradation (Lieber, 1980; Rothschild et al., 1980), and that it alters amino acid transport and amino acid levelsin various tissues, including brain cells (Chambers et aI., 1966; Israel et aI.,1968, 1969; Hakkinen and Kulonen, 1959, 1961, 1967; Roach and Reese, 1971;Roach et aI., 1973a,b).
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Michaelis, E.K., Michaelis, M.L. (1983). Physico-Chemical Interactions between Alcohol and Biological Membranes. In: Research Advances in Alcohol and Drug Problems. Research Advances in Alcohol and Drug Problems, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3626-6_4
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