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The Use of Disulfiram and Other Alcohol-Sensitizing Drugs in the Treatment of Alcoholism

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Book cover Research Advances in Alcohol and Drug Problems

Part of the book series: Research Advances in Alcohol and Drug Problems ((AADP,volume 7))

Abstract

The alcohol-sensitizing drugs are used with the expectation of deterring alcoholics from further drinking. Even though many drugs are available, only disulfiram (tetraethylthiuram disulfide®, Antabuse, Abstinyl®) and possibly calcium carbimide (citrated calcium carbimide, Temposil®, Abstem®) have current therapeutic applications in primary* alcoholics (Sellers et al., 1981). Disulfiram is available in many countries, whereas calcium carbimide is prescribed less frequently and is not available in the United States. Notwithstanding the many claims for the effectiveness of these drugs, their continued use in alcoholism treatment has been questioned (Fried, 1977) because of reports of drug-induced toxicity (Peachey et al., 1981a) and lack of experimental evidence that they are efficacious in exerting a positive treatment outcome (Mottin, 1973; Naranjo, 1983).

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Authors and Affiliations

  1. Behavioural Pharmacotherapy Program, Addiction Research Foundation Clinical Institute, and Departments of Pharmacology and Psychiatry, University of Toronto, Toronto, Ontario, M5S 2S1, Canada

    John E. Peachey

  2. Clinical Pharmacology Program, Addiction Research Foundation Clinical Institute, and Departments of Pharmacology and Medicine, University of Toronto, Toronto, Ontario, M5S 2S1, Canada

    Claudio A. Naranjo

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Peachey, J.E., Naranjo, C.A. (1983). The Use of Disulfiram and Other Alcohol-Sensitizing Drugs in the Treatment of Alcoholism. In: Research Advances in Alcohol and Drug Problems. Research Advances in Alcohol and Drug Problems, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3626-6_10

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