Abstract
The alcohol-sensitizing drugs are used with the expectation of deterring alcoholics from further drinking. Even though many drugs are available, only disulfiram (tetraethylthiuram disulfide®, Antabuse, Abstinyl®) and possibly calcium carbimide (citrated calcium carbimide, Temposil®, Abstem®) have current therapeutic applications in primary* alcoholics (Sellers et al., 1981). Disulfiram is available in many countries, whereas calcium carbimide is prescribed less frequently and is not available in the United States. Notwithstanding the many claims for the effectiveness of these drugs, their continued use in alcoholism treatment has been questioned (Fried, 1977) because of reports of drug-induced toxicity (Peachey et al., 1981a) and lack of experimental evidence that they are efficacious in exerting a positive treatment outcome (Mottin, 1973; Naranjo, 1983).
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References
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Peachey, J.E., Naranjo, C.A. (1983). The Use of Disulfiram and Other Alcohol-Sensitizing Drugs in the Treatment of Alcoholism. In: Research Advances in Alcohol and Drug Problems. Research Advances in Alcohol and Drug Problems, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3626-6_10
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