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Twin and Adoption Studies

How Good Is the Evidence for a Genetic Role?
  • Robin M. Murray
  • Christine A. Clifford
  • Hugh M. D. Gurling
Part of the Recent Developments in Alcoholism book series (RDIA, volume 1)

Abstract

Research into the possibility that heredity may influence drinking habits is still in its infancy, and the conclusions that can be reached from a number of the available twin and adoption studies are limited by their methodological deficiencies. Nevertheless, the balance of evidence suggests a modest genetic effect on both normal drinking and alcoholism in men, though similar evidence for women is so far lacking. Further studies are required to assess the significance of the genetic contribution, to elucidate exactly what is inherited, and to examine the nature of gene-environment interactions.

Keywords

Twin Study Biological Parent Genetic Contribution Drinking Habit Alcoholic Parent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Jellinek EM: Heredity of the alcoholic, in: Alcohol Science and Society: Yale Summer School of Alcohol Studies, Westport, Connecticut, Greenwood Press, 1946, reissued 1972, pp 105–114.Google Scholar
  2. 2.
    Brunn K, Edwards G, Lumio M, et al: Alcohol Control Policies in Public Health Perspective. Helsinki, Finnish Foundation for Alcohol Studies, 1975.Google Scholar
  3. 3.
    Royal College of Psychiatrists: Alcohol and Alcoholism. London, Tavistock, 1979.Google Scholar
  4. 4.
    Partanen J, Brunn K, Markkanen T: Inheritance of Drinking Behavior. Helsinki, Finnish Foundation for Alcohol Studies, 1966.Google Scholar
  5. 5.
    Cloninger CR, Reich T, Wetzer R: Alcoholism and affective disorders: Familial associations and genetic models, in Goodwin DW, Erickson CK (eds): Alcoholism and Affective Disorders. New York, Spectrum, 1979, p 57.Google Scholar
  6. 6.
    Cederlof R, Friberg L, Lundman T: The interactions of smoking, environment and heredity. Acta Med Scand [Suppl] 202: 1–128, 1977.Google Scholar
  7. 7.
    Loehlin JC: An analysis of alcohol-related questionnaire items from the national twin merit study. Ann NY Acad Sci 197: 117–120, 1972.PubMedCrossRefGoogle Scholar
  8. 8.
    Jonsson E, Nilsson T: Alkoholkonsumtion hos monozygota och alizygota twilling par. Nord Hyg Tidskr 49: 21–25, 1968.PubMedGoogle Scholar
  9. 9.
    Conterio F, Chiarelli B: Study of the inheritance of some daily life habits. Heredity 17: 347–359, 1962.PubMedCrossRefGoogle Scholar
  10. 10.
    Perry A: The effect of heredity on attitudes toward alcohol, cigarettes and coffee. J Appl Psychol 58: 275–277, 1973.CrossRefGoogle Scholar
  11. 11.
    Pederson NL: Genetic and Environmental Factors for Usage of Common Drugs, Ph.D. thesis. University of Colorado, Denver, 1980.Google Scholar
  12. 12.
    Kapprio J, Sarna S, Koskenvuo M, et al: The Finnish Twin Registry. Baseline Characteristics Section II. Helsinki, University of Helsinki Press, 1978.Google Scholar
  13. 13.
    Clifford CA, Fulker DW, Gurling HMD, et al: Preliminary findings from a twin study of alcohol use, in: Gedda L, Parisi P, Nance WA (eds): Progress in Biological Research, vol 69C, Twin Research, 3. New York, Alan R. Liss, 1981, pp 47–52.Google Scholar
  14. 14.
    Kaij L: Alcoholism in Twins. Stockholm, Almqvist and Wiksell, 1960.Google Scholar
  15. 15.
    Kaij L: Definitions of alcoholism and genetic research. Ann NY Acad Sci, 197: 110–119, 1972.PubMedCrossRefGoogle Scholar
  16. 16.
    Schulsinger F: Psychopathy, heredity and environment. Int J Ment Health 1: 190–207, 1972.Google Scholar
  17. 17.
    Crowe RR: An adoptive study of psychopathy: Preliminary results from arrest records and psychiatric hospital records, in: Fieve RR, Rosenthal D, Brill H (eds): Genetic Research in Psychiatry. Baltimore, Johns Hopkins University Press, 1975, p 95.Google Scholar
  18. 18.
    Hutchings B, Mednick SA: Registered criminality in the adoptive and biological parents of registered male criminal adoptees, in Fieve RR, Rosenthal D, Brill H (eds): Genetic Research in Psychiatry. Baltimore, Johns Hopkins University Press, 1975, pp 105–116.Google Scholar
  19. 19.
    Seeley JR: The WHO definition of alcoholism. Q J Stud Alcohol 20: 352–356, 1959.PubMedGoogle Scholar
  20. 20.
    Edwards GE, Gross MM, Keller M, et al: Alcohol-related Disabilities. Geneva, World Health Organization, 1977.Google Scholar
  21. 21.
    Slater E, Shields J: Genetical aspects of anxiety, in Lader M (ed): Studies of Anxiety. Br J Psychiatry Special Publication No. 3. Ashford, Headley Bros, 1969, pp 62–71.Google Scholar
  22. 22.
    Gottesman II, Shields J: Schizophrenia and Genetics: A Twin Study Vantage Point. New York, Academic Press, 1972.Google Scholar
  23. 23.
    Spitzer RL, Endicott J: The Schedule for Affective Disorders and Schizophrenia, Lifetime Version, ed 3. New York, New York State Psychiatric Institute, 1977.Google Scholar
  24. 24.
    Gurling HMD, Clifford CA, Murray RM: Genetic contributions to alcohol dependence and its effect on brain function, in Gedda L, Parisi P, Nance WA (eds): Twin Research vol 3. New York, Alan R. Liss, 1981, pp 71–88.Google Scholar
  25. 25.
    Edwards G, Gross M: Alcohol dependence: provisional description of a clinical syndrome. Br Med J 1: 1058–1061, 1976.PubMedCrossRefGoogle Scholar
  26. 26.
    Hrubec Z, Omenn GS: Evidence of genetic predisposition to alcoholic cirrhosis and psychosis. Alcoholism Clin Exp Res 5: 207–215, 1981.CrossRefGoogle Scholar
  27. 27.
    Roe A: The adult adjustment of children of alcoholic parents raised in foster homes. Q] Stud Alcohol 5: 378–393, 1945.Google Scholar
  28. 28.
    Roe A, Burks B: Adult adjustment of foster children of alcoholic and psychotic parentage and the influence of the foster home, in: Memoirs of the Section on Alcohol Studies, Yale University, No. 3. New Haven, 1945.Google Scholar
  29. 29.
    Goodwin DW, Schulsinger F, Hermansen L, et al: Alcohol problems in adoptees raised apart from alcoholic biological parents. Arch Gen Psychiatry 28: 238–243, 1973.PubMedCrossRefGoogle Scholar
  30. 30.
    Goodwin DW, Schulsinger F, Miller N, et al: Drinking problems in adopted and nonadopted sons of alcoholics. Arch Gen Psychiatry 31: 164–169, 1974.PubMedCrossRefGoogle Scholar
  31. 31.
    Goodwin DW, Schulsinger F, Knop J, et al: Alcoholism and depression in adopted-out daughters of alcoholics. Arch Gen Psychiatry 34: 751–755, 1977.PubMedCrossRefGoogle Scholar
  32. 32.
    Goodwin DW, Schulsinger F, Knop J, et al: Psychopathology in adopted and non-adopted daughters of alcoholics. Arch Gen Psychiatry 34: 1005–1009, 1977.PubMedCrossRefGoogle Scholar
  33. 33.
    Cadoret RJ, Gath A: Inheritance of alcoholism in adoptees. Br J Psychiatry 132: 252–258, 1978.Google Scholar
  34. 34.
    Cadoret RJ, Cain CA, Grove WM: Development of alcoholism in adoptees raised apart from alcoholic biological relatives. Arch Gen Psychiatry 37: 561–563, 1980.PubMedCrossRefGoogle Scholar
  35. 35.
    Kaij L, McNeil TF: Genetic aspects of alcoholism. Adv Biol Psychiatry 3: 54–65.Google Scholar
  36. 36.
    Robins E, Guze S: Classification of affective disorders: The primary-secondary, the endogenous-reaction and the neurotic psychotic concepts, in Katz MM, Shield J (eds): Recent Advances in the Psychobiology of the Depressive Illnesses. Washington, US Government Printing Office, 1972, pp 288–298.Google Scholar
  37. 37.
    Kety SS, Rosenthal D, Wender PH, et al: The types and prevalence of mental illness in the biological and adoptive families of adopted schizophrenics, in Rosenthal D, Kety SS (eds): The Transmission of Schizophrenia. Oxford, Pergamon Press, 1968, pp 345–362.Google Scholar
  38. 38.
    Rosenthal D: The concept of subschizophrenia disorders, in Mednick SA (ed): Genetics, Environment and Psychopathology. New York, McGraw-Hill, 1974, pp 167–176.Google Scholar
  39. 39.
    Bohman M: Some genetic aspects of alcoholism and criminality. Arch Gen Psychiatry 35: 269–276, 1978.PubMedCrossRefGoogle Scholar
  40. 40.
    Cloninger CR, Bohman M, Sigvardsson S: Inheritance of alcohol abuse. Arch Gen Psychiatry 38: 861–868, 1981.PubMedCrossRefGoogle Scholar
  41. 41.
    Schuckit MA, Goodwin DW, Winokur G: A study of alcoholism in half siblings. Am J Psychiatry 128: 1132–1136, 1972.PubMedGoogle Scholar
  42. 42.
    Jackson DD: The Etiology of Schizophrenia. New York, Baire Books, 1960.CrossRefGoogle Scholar
  43. 43.
    Plant M: Drinking Careers. London, Tavistock, 1979.Google Scholar
  44. 44.
    Stalnaker JM, Young D, Young K, et al: Statement from supervising committee, in: Memoirs of the Section on Alcohol Studies, Yale University, No. 3. New Haven, 1945.Google Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Robin M. Murray
    • 1
  • Christine A. Clifford
    • 1
  • Hugh M. D. Gurling
    • 1
  1. 1.Genetics Section, Institute of PsychiatryUniversity of LondonLondonEngland

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