Safe Handling of Toxic Chemicals: Perspectives of a Bench Chemist and Laboratory Manager
In a university environment we have evolved a number of working rules for handling and analysis of toxic samples: (1) secure storage and isolation of samples during workup; (2) use of less toxic surrogate compounds for calibration and testing of analytical scheme; (3) dedicated instruments, work area and personnel; (4) limited number of competent, knowledgeable, motivated personnel doing actual analyses; (5) redundant containment, verified by wipe tests; (6) medical surveillance; (7) close supervision and, (8) careful disposal of contaminated waste. We have also found it advantageous to have a toxicologist working with the analytical team and an analyst working with the toxicologists. With close collaboration and good communication of these groups serious exposure incidents have been avoided and a safe working environment has been maintained.
KeywordsCombustion Foam Epoxy Rubber Chlorinate
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- 1.N. H. Mahle and L. A. Shadoff, The Mass Spectrometry of Chlorinated Dibenzo-p-dioxins, in: “Biomedical Mass Spectrometry” G. Waller, ed., In Press.Google Scholar
- 2.K. J. Voorhees, I. N. Einhorn, F. D. Hileman, and L. H. Wojcik, The identification of a highly toxic bicyclophosphate ester in the combusion products of a fire-retarded urethane foam, J. Polymer Sci., 13: 293 (1975).Google Scholar
- 4.Discussed by K. S. Khera and J. A. Ruddick, Polychlorodibenzo-p-dioxins: perinatal effects and the dominant lethal test in wistar rats in: “Chlorodioxins-Orgin and Fate,” E. H. Blair, ed., Adv. in Chem. Series, 120:70 (1973) and E. H. McConnell, J. A. Moore, J. K. Haseman and M. W. Harris, Toxicol. Appl. Pharmacol. 44:335 (1978).Google Scholar
- 5.D. F. Hunt, T. M. Harvey and J. W. Russell, Oxygen as a reagent gas for the analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin by negative ion chemical ionization mass spectometry, J. Chem. Soc., Chem. Commun., 152 (1975).Google Scholar
- 6.M. L. Gross, Interlaboratory validation in dioxin analysis, presented at International Symposium on Chlorinated Dioxins and Related Compounds These Proceedings.Google Scholar
- 7.L. A. Shadoff, Personal Communication, Analytical Laboratories, 574 Building, Dow Chemical Laboratories, U.S.A., Midland, Michigan 48640. Also described briefly in reference 1.Google Scholar
- 8.G. D. Lathrop and W. H. Wolfe, A medical surveillance program for scientists exposed to dioxins and furans. These Proceedings.Google Scholar