Methodology of Clinical Studies on Exposed Populations
Much progress has been made in the field of toxicology as it applies to safety evaluation and in the area of trace analysis for chemicals. It is now assume by many that this technology can simply be transferred to studies of human populations in field situations. Unfortunately, many problems are encountered when this is done. The heterogeneity of the general population, the long life span of humans, the lack of information about baseline data are but a few factors. Tests to detect subclinical effects have, in many instances, not been developed to the point where they can be used as screening tools. Other tests that are used may not really be relevant for specific problems. For many such tests, it is not known how they can be used to make predicitions about the health status of the individual at the time the test is done or about his or her health in the future.
KeywordsBody Burden Toxic Shock Syndrome Hemorrhagic Cystitis Quality Control System Lipid Research Clinic
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