Adipose Tissue Storage of Polychlorinated Compounds
Adipose tissue storage of lipophilic compounds is not simply a matter of lipophilicity and is more complex than was commonly assumed. DDT and related compounds are among the classical xenobiotics stored in adipose tissue. The latter contains most of the body burden, but the material so sequestered is also removed from potential target organs where toxicity might become manifest. However, if the adipose tissues are metabolized, stored material can be released. It is then transferred into lean tissues accompanied by increased excretion via the feces. Therefore, at the same time as the body burden overall decreases, concentrations in certain tissues increase. This is also the case with 2,4,5,2’,4’,5’-hexachlorobiphenyl (6-CB), an extremely persistent model compound, which has been shown to be retained for months in high constant amounts in adipose tissue when acutely administered to rats. In rats with restricted food intake the kinetics of 6-CB release from adipose tissue and of its redistribution and enhanced fecal excretion have been investigated. The results may provide a model for other classes of polychlorinated compounds.
KeywordsAdipose Tissue Organochlorine Pesticide Body Burden Fecal Excretion Lipophilic Compound
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