Skip to main content
SpringerLink
Log in

An Exposure System for Quantitative Measurements of the Microbial Mutagenicity of Volatile Liquids

  • Chapter
Genotoxic Effects of Airborne Agents

Part of the book series: Environmental Science Research ((ESRH,volume 25))

Abstract

It has been estimated that 5 × 1010 grams per day of vapor-phase chemicals and 109 grams per day of particulate matter are released into the atmosphere in the United States (1). Since both of these fractions may contribute to the toxic potential of the atmosphere, it seems important to be able to evaluate them in a precise manner.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. T. J. Hughes, E. Pellizzari, L. Little, C. Sparacino, and A. Kolber, Ambient air pollutants: Collection, chemical characterization, and mutagenicity testing, Mutat. Res. 76: 51–83 (1980).

    Google Scholar 

  2. B. N. Ames, J. McCann, and E. Yamasaki, Methods for detecting carcinogens and mutagens with the Salmonella/Mammalian microsome mutagenicity test, Mutat. Res. 31: 347–364 (1975).

    Google Scholar 

  3. T. Sugimura, M. Nagaro, T. Kawachi, M. Honda, T. Yahagi, Y. Seino, S. Sato, N. Matsukura, T. Matsushima, A. Shirai, M. Sawamura, and H. Matsumoto, Mutagen-Carcinogens in food with special reference to highly mutagenic pyrolytic products in broiled foods in origins of human cancer, in: “Origins of Human Cancer” H. H. Hiant, J. D. Watsun and J. A. Winston, eds., Cold Spring Harbor Laboratory, 1561–1578 (1977).

    Google Scholar 

  4. B. Commoner, A. J. Vithayathil, P. Dolara, S. Nair, P. Madyastha, and G. C. Cuca, Formation of mutagens in beef and beef extract during cooking, Science 201: 913–916 (1978).

    Article  ADS  Google Scholar 

  5. N. E. Springarm, L. A. Slocum, and J. H. Weisburger, Formation of mutagens in cooked foods. III. Foods with high starch content, Cancer Lett. 9: 7–12 (1980).

    Article  Google Scholar 

  6. H. U. Aeschbacher and H. P. Wurzner, An evaluation of instant and regular coffee in the Ames mutagenicity test, Toxicol. Lett. 5: 139–145 (1980).

    Article  Google Scholar 

  7. J. S. K. Lee and L. Y. Y. Fong, Mutagenicity of Chinese alcoholic spirits, Food Cosmet. Toxicol. 17: 575–578 (1979).

    Article  Google Scholar 

  8. B. Commoner, Carcinogens in the environment, Chemtech, February (1977).

    Google Scholar 

  9. J. N. Pitts, K. A. VanCauvenberghe, D. Grosjean, J. P. Schmid, D. R. Fitz, W. L. Belser, G. B. Knudson, and P. M. Hynds, Atmospheric reactions of polycyclic aromatic hydrocarbons: Facile formation of mutagenic nitro derivatives, Science 202: 515–519 (1978).

    Article  ADS  Google Scholar 

  10. C. E. Chrisp, G. L. Fisher, and J. E. Lammert, Mutagenicity of filtrates from respirable coal fly ash, Science 199: 73–75 (1977).

    Article  ADS  Google Scholar 

  11. B. A. Glatz, C. D. Chriswell, M. D. Argueilo, H. J. Svec, J. S. Fritz, S. M. Grimm, and M. A. Thomson, Examination of drinking water for mutagenic activity, J. Amer. Water Works Asso., August, 465 (1978).

    Google Scholar 

  12. N. Gruener, Mutagenicity of ozonated, recycled water, Bull. Environ. Contam. and Toxicol. 20: 522–526 (1978).

    Article  Google Scholar 

  13. W. G. Honer, M. J. Ashwood-Smith, and C. Warby, Mutagenic activity of swimming pool water, Mutat. Res. 78: 137–144 (1980).

    Article  Google Scholar 

  14. S. Sato, Y. Seino, T. Ohka, T. Yahagi, M. Nagao, T. Matsushima, and T. Sugimura, Mutagenicity of smoke condensates from cigarettes, cigars, and pipe tobacco, Cancer Lett. 3: 1–8 (1977).

    Article  Google Scholar 

  15. J. McCann, E. Choi, E. Yamasaki, and B. N. Ames, Detection of carcinogens as mutagens in the Salmonella/micro some mutagenicity test, Proc. Nat. Acad. Sci. (U.S.A.) 72: 5135–5139 (1975).

    Article  ADS  Google Scholar 

  16. J. M. Muzzall and W. L. Cook, Mutagenicity test of dyes used in cosmetics with the Salmonella/mammalian microsome test, Mutat. Res. 67: 1–8 (1979).

    Article  Google Scholar 

  17. W. T. Speck, A. B. Stein, and H. S. Rosenkranz, Mutagenicity of metronidazole: Presence of several active metabolites in human urine, J. Nat. Cancer Inst. 56: 283–284 (1976).

    Google Scholar 

  18. M. D. Gold, A. Blum, and B. N. Ames, Another flame retardant, tris-(l,3-dichloro-2-propyl)phosphate and its expected metabolites are mutagens, Science 200: 785–787 (1978).

    Article  ADS  Google Scholar 

  19. J. A. Heddle and W. R. Bruce, Comparison of tests for mutagenicity or carcinogenicity using assays for sperm abnormalities, formation of micronucleii and mutations in Salmonella, in: “Origins of Human Cancer”, H. H. Hiatt, J. D. Watson, and J. A. Winsten, eds., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 151557 (1977).

    Google Scholar 

  20. T. Sugimura, S. Sato, M. Nagao, T. Yahagi, T. Matsushima, Y. Seino, M. Takeuchi, and T. Kawachi, Overlapping of carcinogens and mutagens, in: “Fundamentals in Cancer Prevention”, Baltimore University Park Press, 191–215 (1976).

    Google Scholar 

  21. S. J. Rinkus and M. Legator, Chemical characterization of 465 known or suspected carcinogens and their correlation with mutagenic activity in the Salmonella typhimurium system, Cancer Res. 39: 3289–3318 (1979).

    Google Scholar 

  22. J. M. Baden, M. Brinkerhoff, R. S. Wharton, B. A. Hitt, V. F. Simmon, and R. I. Mazze, Mutagenicity of volatile anesthetics: Halothane, Anesthesiology 45: 311–318 (1976).

    Article  Google Scholar 

  23. J. M. Baden and V. F. Simmon, Mutagenic effects of inhalation anesthetics, Mutat. Res. 75: 169–189 (1980).

    Google Scholar 

  24. H. Bartsch, C. Malaveille, R. Montesano, and L. Tomatis, Tissue mediated mutagenicity of vinyledine chloride and 2-chloro-butadiene in S. typhimurium, Nature 255: 641–643 (1975).

    Article  ADS  Google Scholar 

  25. H. Brem, A. B. Stein, and H. S. Rosenkranz, The mutagenicity and DNA-modifying effect of haloalkanes, Cancer Res. 34: 2576–2579 (1974).

    Google Scholar 

  26. B. A. Bridges, On the detection of volatile mutagens with bacteria: Experiments with dichlorovos and epichlorohydrin, Mutat. Res. 54: 367–371 (1978).

    Google Scholar 

  27. C. deMeester, M. Diverger-vanBogaert, M. Lambotte-Vandepaer, M. Roberfroid, F. Poncelet, and M. Mercier, Mutagenicity of vinyl chloride in the Ames test. Possible artifacts related to experimental conditions, Mutat. Res. 77: 175–179 (1980).

    Google Scholar 

  28. W. M. F. Jongen, G. M. Alink, and J. H. Koeman, Mutagenic effect of dichloromethane on Salmonella typhimurium, Mutat. Res. 56: 245–248 (1978).

    Article  Google Scholar 

  29. J. F. Russel, M. E. Sippel, and D. F. Krahn, Methods for the detection of mutagenic gases and volatile liquids in the Salmonella/micro some assay, Environmental Mutagen Society 11th Annual Meeting, Nashville, Abstract (1980).

    Google Scholar 

  30. V. F. Simmon, Structural correlations of carcinogenic and mutagenic alkyl halides, in: Proceedings of the Second FDA Office of Science Summer Symposium, I. M. Asher and C. Zervos, eds., (1977).

    Google Scholar 

  31. E. D. Barber, W. D. Donish, and K. R. Mueller, Quantitative measurement of the mutagenicity of volatile liquids in the Ames Salmonella/micro some assay, Environmental Mutagen Society 11th Annual Meeting, Nashville, Abstract (1980).

    Google Scholar 

  32. H. J. Vogel and D. M. Bonner, Acetylornithinase of E. coli: Partial purification and some properties, J. Biol. Chem. 218: 97–106 (1956).

    Google Scholar 

  33. C. Malaveille, G. Planche, and H. Bartsch, Factors for efficiency of the Salmonella/microsome mutagenicity assay, Chemical-Biological Interactions 17: 129–136 (1977).

    Article  Google Scholar 

  34. M. S. Kelley and J. M. Baden, Duration of S-9 Activity, Environmental Mutagenesis Society llAnnual Meeting, Nashville, Abstract (1980).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Eastman Kodak Co., Rochester, NY, 14650, USA

    Eugene D. Barber & William H. Donish

Authors
  1. Eugene D. Barber
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. William H. Donish
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Brookhaven National Laboratory, New York, Upton, USA

    Raymund R. Tice , Daniel L. Costa  & Karen M. Schaich ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Plenum Press, New York

About this chapter

Cite this chapter

Barber, E.D., Donish, W.H. (1982). An Exposure System for Quantitative Measurements of the Microbial Mutagenicity of Volatile Liquids. In: Tice, R.R., Costa, D.L., Schaich, K.M. (eds) Genotoxic Effects of Airborne Agents. Environmental Science Research, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3455-2_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-3455-2_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3457-6

  • Online ISBN: 978-1-4613-3455-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation