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Mutagenicity of Selected Chemicals in Drosophila

  • E. Vogel
  • A. Schalet
  • W. R. Lee
  • F. Würgler

Abstract

This review of mutagenicity data involving the 20 reference mutagens in Drosophila is restricted to data that were considered relevant for the purpose of the comparative evaluation. Although an effort was made to include information from as many sources as possible (approximately 500 papers were checked and representative material from about 140 papers was selected), the reports are not intended to review all studies reported in the literature Each of the 20 compounds is reviewed separately in a small report containing three sections (treatment conditions; biological effects; evaluation). References are given in a single bibliography at the end. In the following section we will consider briefly the genetic endpoints which were preferentially used for assaying the chemicals under consideration.

Keywords

Genetic Damage Chromosome Loss Vinyl Chloride Monomer Adult Feeding Recessive Lethal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Vogel, E., arid Leigh, B. Mutat. Res. 29: 383–396 (1975).CrossRefGoogle Scholar
  2. 2.
    Vogel, E. Mutat. Res. 33: 221–228 (1975).CrossRefGoogle Scholar
  3. 3.
    Auerbach, C. In: Mutation — an Introduction to Research on Mutagenesis. Part I. Methods. C. Auerbach, Ed., Oliver and Boyd, Edinburgh and London, 1962, pp. 27–67.Google Scholar
  4. 4.
    Würgler, F. E., and Ulrich, H. In: The Genetics and Biology of Drosophila, Vol. 1c, M. Ashburner and E. Novitiski, Eds., Academic Press, London-New York-San Francisco, 1976, pp. 1269–1298.Google Scholar
  5. 5.
    Traut, H. Internat. J. Rad. Biol. 7: 401–403 (1963).CrossRefGoogle Scholar
  6. 6.
    Abrahamson, S., and Lewis, E. G. In: Chemical Mutagens, Vol. 2, A. Hollaender, Ed., Plenum Press, New York, 1971, pp. 461–487.Google Scholar
  7. 7.
    Muller, H. J., and Oster, I. I. In: Methodology in Basic Genetics, W. J. Burdette, Ed., Holden-Day, San Francisco, 1963, pp. 240–278.Google Scholar
  8. 8.
    Vogel, E., and Sobels, F. H. In: Chemical Mutagens, Vol. 4, A. Hollaender, Ed., Plenum Press, New York, 1976, pp. 93–141.Google Scholar
  9. 9.
    Würgler, F. E., Sobels, F. H., Vogel, E. In: Handbook of Mutagenicity Test Procedures, B. J. Kilbey, M. Legator, W. Nichols and C. Ramel, Eds., Elsevier/North Holland Biomedical Press, 1977, pp. 335–373.Google Scholar
  10. 10.
    Vogel, E. In: The Origins of Human Cancer, H. H. Hiatt, J. D. Watson, and J. A. Winston, Eds., Cold Spring Harbor Lab., 1977, pp. 1483–1497.Google Scholar
  11. 11.
    Baars, A. J., Zijlstra, J. A., Vogel, E., and Breimer, D. D. Mutat. Res. 44: 257–268 (1977).CrossRefGoogle Scholar
  12. 12.
    Lamb, M., and Lilly, J. L. Mutat. Res. 11: 430–433 (1971).Google Scholar
  13. 13.
    Lilly, J. L., and Lamb, M. J. EMS Newsletter 6: 26 (1972).Google Scholar
  14. 14.
    Sorsa, M., and Pfeifer, S. Hereditas 75: 273–277 (1973).CrossRefGoogle Scholar
  15. 15.
    Bertram, C., Höhne, G. Strahlentherap. 43: 388–391 (1959).Google Scholar
  16. 16.
    Frye, S. Brit. Empire Cancer Campaign, 38th Ann. Rept., Pt. 2: 670 (1960).Google Scholar
  17. 17.
    Röhrborn, G. Mol. Gen. Genetics, 102: 50–68 (1968).Google Scholar
  18. 18.
    Verburgt, F. G. and Vogel, E. Mutat. Res. 48: 327–336 (1977).CrossRefGoogle Scholar
  19. 19.
    Magnusson, J., and Ramel, C. Mutat. Res. 38: 115 (1976).Google Scholar
  20. 20.
    Vogel, E. In: Screening Tests in Chemical Carcinogenesis (IARC Scientif. Publ. No. 12), R. Monesano, H. Bartsch, and L. Tomatis 4 Eds., IARC, Lyon, 1976, pp. 117–132.Google Scholar
  21. 21.
    Fahmy, 0. G., Fahmy, M. J., Massasso, J., and Ondrej, M. J. Mutat. Res. 3: 201–217 (1966).CrossRefGoogle Scholar
  22. 22.
    Fahmy, 0. G., and Fahmy, M. J. Mutat. Res. 6: 139–154 (1968).CrossRefGoogle Scholar
  23. 23.
    Pasternak. L. Acta Biol. Med. Ger., 10: 436–438 (1963).Google Scholar
  24. 24.
    Pasternak, L. Arzneimittelforsch. 14: 802–804 (1964).Google Scholar
  25. 25.
    Vogel, E. Unpublished data.Google Scholar
  26. 26.
    Fahmy, O. G., and Fahmy, M. J. Chem. Biol. Interact. 11: 395–412 (1975).CrossRefGoogle Scholar
  27. 27.
    Fahmy, O. G., and Fahmy, M. J. Cancer Res. 35: 3780–3784 (1975).Google Scholar
  28. 28.
    Ondrej, M. Folia Biol. (Prague), 15: 17–25 (1969).Google Scholar
  29. 29.
    Pasternak, L. Naturwiss. 49: 381 (1962).ADSCrossRefGoogle Scholar
  30. 30.
    Ondrej, M. Folia Biol. (Prague) 16: 225–229 (1970).Google Scholar
  31. 31.
    Rapoport, J. A. Genetika 60: 469–472 (1948).Google Scholar
  32. 32.
    Kramers, P. G. N. Unpublished data.Google Scholar
  33. 33.
    Alexander, M. L., and Glanges, L. Genetics 50: 231–232 (1964).Google Scholar
  34. 34.
    Alexander, M. L., and Glanges, L. Proc. Nat. Acad. Sci. (U.S.A.) 53: 282–288 (1965).ADSCrossRefGoogle Scholar
  35. 35.
    Sram, R. J. Mutat. Res. 9: 243–244 (1970).CrossRefGoogle Scholar
  36. 36.
    Lim, J. K., and Snyder, L. A. Mutat. Res. 6: 129–137 (1968).CrossRefGoogle Scholar
  37. 37.
    Watson, W. A. F. Z. Vererb. 95: 374–378 (1964).CrossRefGoogle Scholar
  38. 38.
    Ratnayake,. W. Mutat. Res. 5: 271–278 (1971).Google Scholar
  39. 39.
    Sram, R. J. Mol. Gen. Genet. 106: 286–288 (1977).CrossRefGoogle Scholar
  40. 40.
    Lim, J. K., and Snyder, L. A. Proc. Int. Congr. Genet., 12; 85 (1968).Google Scholar
  41. 41.
    Slizynska, H. Genet. Res. 4 248–257 (1963).Google Scholar
  42. 42.
    Slizynska, H. Mutat. Res. 19: 199–213 (1973).CrossRefGoogle Scholar
  43. 43.
    Aaron, C. S., and Lee, W. R. Dros. Inf. Service, 52: 64 (1977).Google Scholar
  44. 44.
    Browning, S. Dros. Inf. Service, 45; 75–76 (1970).Google Scholar
  45. 45.
    Fahmy, 0. G., and Fahmy, M. J. Genetics. 46: 361 (1961).Google Scholar
  46. 46.
    Hotchkiss, S. K., and Lim, J. K. Dros. Inf. Service 43: 116 (1968).Google Scholar
  47. 47.
    Lee, W. R. Mutat. Res. 38: 311–316 (1976).Google Scholar
  48. 48.
    Lewis, E. B., and Bacher, F. Dros. Inf. Service 43: 193 (1968).Google Scholar
  49. 49.
    Watson, W. A. F. Mutat. Res. 14: 299–307 (1972).CrossRefGoogle Scholar
  50. 50.
    Abrahamson, S., and Lewis, E. G. In: Chemical Mutagens, Vol. 2, A. Hollaender, Ed., Plenum Press, New York, 1971, pp. 461–487.Google Scholar
  51. 51.
    Bishop, J., and Lee, W. R. Genetics 61: S4–5 (1969).Google Scholar
  52. 52.
    Schalet, A. Genetics 86: 55 (1977).Google Scholar
  53. 53.
    Jenkins, J. B. Mutat. Res. 4 90–92 (1967).Google Scholar
  54. 54.
    Lee, W. R., Sega, G. A., and Bishop, J. B. Genetics 60: 196 (1968).Google Scholar
  55. 55.
    Jenkins, J. B. Mutat. Res. 7: 487–489 (1969).CrossRefGoogle Scholar
  56. 56.
    Lee, W. R., Sega, G. A., and Bishop, J. B. Mutat. Res. 9: 320–336 (1970).Google Scholar
  57. 57.
    Jenkins, J. B. Genetics 57: 783–793 (1967).Google Scholar
  58. 58.
    Lim, J. K., and Snyder, L. A. Genetics 74.: S158–S159 (1973).Google Scholar
  59. 59.
    Lim, J. K., and Snyder, L. A. Genet. Res. 24: 1–10 (1974).CrossRefGoogle Scholar
  60. 60.
    Huang, S. L., and Baker, B. S. Mutat. Res. 34: 407–414 (1976).CrossRefGoogle Scholar
  61. 61.
    Lee, W. R. In: Radiation Research, Biomedical, Chemical and Physical Perspectives, O. F. Nijgaard, H. I. Adler, and W. K. Sinclair, Eds., Academic Press, New York, 1975, pp. 976–983.Google Scholar
  62. 62.
    Lee, W. R. In: The Genetics and Biology of Drosophila, M. Ashburner and E. Novitski, Eds., Academic Press, New York, 1976, pp. 1299–1341.Google Scholar
  63. 63.
    Aaron, C. S., Lee, W. R., Janca, F. C., and Seamster, P. M. Genetics 74: S1 (1973).Google Scholar
  64. 64.
    Epler, J. L. Genetics 48: 663–675 (1963).Google Scholar
  65. 65.
    Aaron, C. S., and Lee, W. R. Dros. Inf. Service 52 64 (1977).Google Scholar
  66. 66.
    Legator, M. S., Zimmering, S., and Connor, T. H. In: Chemical Mutagens, Principles and Methods for Their Detection, A. Hollaender, Ed., Plenum Press, New York, 1976, pp. 171–190.Google Scholar
  67. 67.
    Hochman, B. Genetics 67: 235–252 (1971).Google Scholar
  68. 68.
    Lifschytz, E., and Falk, R. Mutat. Res. 8: 147–155 (1969).CrossRefGoogle Scholar
  69. 69.
    Schalet, A., and Lefevre, Jr., G. Chromosoma 44: 183–202 (1973).CrossRefGoogle Scholar
  70. 70.
    Wright, R. F., Hodgetts, R. B., and Sherald, A. F. Genetics 84: 267–285 (1976).Google Scholar
  71. 71.
    Carlson, E. A., and Southin, J. L. Genetics 48: 663–675 (1963).Google Scholar
  72. 72.
    Snyder, L. A., and Oster, I. I. Mutat. Res. 1: 437–445 (1964).CrossRefGoogle Scholar
  73. 73.
    Woodruff, R. C., and Johnson, T. K. Genetics 74: S299 (1973).Google Scholar
  74. 74.
    Woodruff, R. C., and Ganer, R. M. Mutat. Res. 25: 337–345 (1974).CrossRefGoogle Scholar
  75. 75.
    Kumar, S., and Sharma, R. P. Experientia 23: 266–267 (1967).CrossRefGoogle Scholar
  76. 76.
    Browning, L. S., and Altenburg, E. Genetics 47: 945 (1962).Google Scholar
  77. 77.
    Carlson, E. A., and Oster, I. I. Genetics 47: 561–576 (1962).Google Scholar
  78. 78.
    Southin, J. L., Mutat. Res. 3 54–65 (1966).CrossRefGoogle Scholar
  79. 79.
    Carlson, E. A. Genetics 55: 295–313 (1967).Google Scholar
  80. 80.
    Burychenko, G. M. Sov. Genet. 5: 1494 (1969).Google Scholar
  81. 81.
    Fahmy, 0. G., and Fahmy, M. J. Nature 180: 31 (1957).ADSCrossRefGoogle Scholar
  82. 82.
    Burychenko, G. M. Sov. Genet. 4: 1337 (1968).Google Scholar
  83. 83.
    Khan, A. H. Mutat. Res. 8: 165–175 (1969).CrossRefGoogle Scholar
  84. 84.
    Lim, J. K., and Snyder, L. A. Genetics 61: S37 (1969).Google Scholar
  85. 85.
    Smith, P. D. Mutat. Res. 20: 215–220 (1973).CrossRefGoogle Scholar
  86. 86.
    Bateman, A. J., and Chandley, A. C. Heredity 19: 711 (1964).CrossRefGoogle Scholar
  87. 87.
    Würgler, F., personal communication.Google Scholar
  88. 88.
    Leigh, B., personal communication.Google Scholar
  89. 89.
    Fahmy, O. G., and Fahmy, M. J. Genetics 46: 447 (1961).Google Scholar
  90. 90.
    Liu, C. P., and Lim, J. K. Genetics 79: 601–611 (1975).Google Scholar
  91. 91.
    Liu, C. P., and Lim, J. K. Genetics 77: S40 (1974).Google Scholar
  92. 92.
    Gatti, M., Pimpinelli, S., de Marco, A., and Tanzarella, C. Mutat. Res. 33: 201–212 (1975).CrossRefGoogle Scholar
  93. 93.
    Mailing, H. V., and de Serres, F. J. Mutat. Res. 18: 1–14 (1973).CrossRefGoogle Scholar
  94. 94.
    Benes, V., and Sram, R. Ind. Med. 38: 50–52 (1969).Google Scholar
  95. 95.
    Browning, L. S. Genetics 60: 165–155 (1968).Google Scholar
  96. 96.
    Browning, L. S. Mutat. Res. 8: 157–164 (1969).CrossRefGoogle Scholar
  97. 97.
    Khan, A. H. Dros. Inform. Service 43: 112 (1968).Google Scholar
  98. 98.
    Fahmy, O. G., and Fahmy, M. J. Mutat. Res. 13: 19–34 (1971).CrossRefGoogle Scholar
  99. 99.
    Browning, L. S. EMS Newsletter 3: 37 (1970).Google Scholar
  100. 100.
    Fahmy, O. G., and Fahmy, M. J. Cancer Res. 32: 550–557 (1972).Google Scholar
  101. 101.
    Judd, B. H., Shen, M. W., and Kaufman, T. C. Genetics 71: 130–156 (1972).Google Scholar
  102. 102.
    Fahmy, O. G., and Fahmy, M. J. J. Genetics 54: 146–164 (1956).CrossRefGoogle Scholar
  103. 103.
    Browning, L. S., and Altenburg, E. Genetics 46: 1317–1321 (1961).Google Scholar
  104. 104.
    Fahmy, O. G., and Fahmy, M. J. Genetics 46: 1111–1123 (1961).Google Scholar
  105. 105.
    Rohrborn, G. Z. Vererb. 90: 116–131 (1959).CrossRefGoogle Scholar
  106. 106.
    Hayashi, S., and Suzuki, D. T. Can. J. Gen. Cytol. 10: 276–282 (1968).Google Scholar
  107. 107.
    Suzuki, D. T., Piternick, L. K., Hayashi, S., Tarasoff, M., Baillie, D., and Erasmus, U. Proc. Nat. Acad. Sci. (U.S.) 57: 907–912 (1967).ADSCrossRefGoogle Scholar
  108. 108.
    Suzuki, D. T. Science 170: 695–706 (1970).ADSCrossRefGoogle Scholar
  109. 109.
    Schewe, M., Suzuki, D. T., and Erasmus, U. Mutat. Res. 12: 255–267 (1971).CrossRefGoogle Scholar
  110. 110.
    Ostertag, W., and Haake, J. Z. Vererb. 98: 299–301 (1966).CrossRefGoogle Scholar
  111. 111.
    Schewe, M., Suzuki, D. T., and Erasmus, U. Mutat. Res. 12: 269–279 (1971).CrossRefGoogle Scholar
  112. 112.
    Walker, V. K., and Williamson, J. H. Mutat. Res. 28: 227–237 (1975).CrossRefGoogle Scholar
  113. 113.
    Mukherjee, R. Genetics 51: 947–951 (1955).Google Scholar
  114. 114.
    Parker, D. R., and Hammond, A. E. Mutat. Res. 9 273–286 (1970).Google Scholar
  115. 115.
    Szybalski, W., and Iyer, V. N. Microbiol. Genet. Bull. 21: 16 (1964).Google Scholar
  116. 116.
    Blijleven, W. G. H., and Vogel, E. Mutat. Res. 45: 47–59 (1977).CrossRefGoogle Scholar
  117. 117.
    Blijleven, W. G. H., unpublished data.Google Scholar
  118. 118.
    Reed, D. J. In: Handbook of Experimental Pharmacology, A. C. Sartorelli and D. G. Johns, Eds., Vol. 38, Part 2, Springer Verlag, Berlin-Heidelberg-New York, 1975, pp. 747–765.Google Scholar
  119. 119.
    Herskowitz, I. H. Genetics 40: 574 (1955).Google Scholar
  120. 120.
    Herskowitz, I. H. Genetics 41: 605–609 (1956).Google Scholar
  121. 121.
    Lüers, H. Arch. Geschwulstforsch. 6: 77–83 (1953).Google Scholar
  122. 122.
    Snyder, L. A., and Oster, I. I. Mutat. Res. 1: 437–445 (1968).Google Scholar
  123. 123.
    Bird, M. J. J. Genet.. 50: 480–485 (1952).CrossRefGoogle Scholar
  124. 124.
    Fahmy, O. G., and Fahmy, M. J. J. Genet. 52: 603–619 (1954).CrossRefGoogle Scholar
  125. 125.
    Fahmy, O. G., and Fahmy, M. J. J. Genet. 53: 566–584 (1955).Google Scholar
  126. 126.
    Slizynska, H. Mutat. Res. 19: 199–213 (1973).CrossRefGoogle Scholar
  127. 127.
    Slizynska, H. Mutat. Res. 8: 165–175 (1969).CrossRefGoogle Scholar
  128. 128.
    Snyder, I. A. Z. Vererb. 94: 182–189 (1963).CrossRefGoogle Scholar
  129. 129.
    Slizynska, H. Genet. Res. 4: 248–257 (1963).CrossRefGoogle Scholar
  130. 130.
    Sram, R. J. Folia Biol. (Prague) 18: 139–148 (1972).Google Scholar
  131. 131.
    Kocisova, J., and Sram, R. J. Folia 332 (1974).Google Scholar
  132. 132.
    Lüers, H., and Röhrborn, G. Mutat. Res. 2: 29–44 (1965).CrossRefGoogle Scholar
  133. 133.
    Lüers, H., and Röhrborn, G. Genet. Today, Proc. Int. Congr. 11th, 1: 64–65 (1963).Google Scholar
  134. 134.
    Fahmy, O. G., and Fahmy, M. J. Cancer Res. 30: 195–205 (1970).Google Scholar
  135. 135.
    Mollet, P. Mutat. Res. 21: 137–148 (1973).CrossRefGoogle Scholar
  136. 136.
    Mollet, P., Graf, U., and Würgler, F. E. Arch. Genetik 47: 184–190 (1974).Google Scholar
  137. 137.
    Vogel, E. Mutat. Res. 20: 330–352 (1973).Google Scholar
  138. 138.
    Vogel, E., and Lüers, H. Dros. Inform. Service 51: 113–114 (1974).Google Scholar
  139. 139.
    Büchei, R., and Bürki, K. Arch. Genetik 48: 59–67 (1975).Google Scholar
  140. 140.
    Mollet, P., and Büchi, R. Dros. Inform. Service 51: 96–97 (1974).Google Scholar
  141. 141.
    Nasrat, G. E., Kaplan, W. D., and Auerbach, C. Indukt. Abstammungsl. Vererb. 816: 240–262 (1964).Google Scholar
  142. 142.
    Vogel, E. Mutat. Res. 14: 250–253 (1972).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • E. Vogel
    • 1
  • A. Schalet
    • 1
  • W. R. Lee
    • 2
  • F. Würgler
    • 3
  1. 1.Department of Radiation Genetics and Chemical MutagenesisState University of LeidenLeidenThe Netherlands
  2. 2.Department of Zoology and PhysiologyLouisiana State UniversityBaton RougeUSA
  3. 3.Institute für Toxikologie der ETH und der Universität ZürichSchwerzenbach bei ZürichSwitzerland

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