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Comparative Mutagenicity of Mitomycin C

  • Ilse-Dore Adler

Abstract

Mitomycin C (MC) was first isolated from Streptomyces caesipitosus (1). It was demonstrated to have antibiotic and antitumor properties. Closely related antibiotics, designated mitomycin A and B and porfiromycin have also bee isolated (2). Mitomycins are colored, basic substances forming reddish-violet, plate or needle-shaped crystals. The antibiotic family was described as having unique, naturally occurring structural configurations, in that it represents the first recorded example of the formation by a microbial system of an aziridine group, the pyrrol-(1,2-a)- indole ring system, an aminobenzoquinone, and a pyrrolizine. The common mitomycin nucleus is termed Mitosane. The different compounds only vary by minor substituent groupings (3).

Keywords

Chromosome Aberration Sister Chromatid Exchange Mouse Bone Marrow Recessive Lethal Chromatid Aberration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Ilse-Dore Adler
    • 1
  1. 1.Institut für GenetikGesellschaft für Strahlen- und UmweltforschungNeuherberg bei MünchenFederal Republic of Germany

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