Mutagenicity of Selected Chemicals in Mammals: The Heritable Translocation Test

  • W. M. Generoso
  • B. Cattanach
  • A. M. Malashenko


Male translocation heterozygotes may be either partially sterile (semisterile) or completely sterile, depending upon the position of the breaks or whether or not the sex chromosomes are involved. Since translocation heterozygotes do not show phenotypic characteristics that distiguish them from normal mice, translocation heterozygotes cannot be detected by casual observation of the progeny. On the other hand, translocation heterozygotes have two characteristic features that allow unequivocal detection of these animals. First, translocation heterozygotes produce two types of gametes; balanced and unbalanced. Complete sterility and presence of unbalanced gametes are easily revealed by fertility testing. Second, because of pairing of homologous chromosome regions and formation of chiasmata in these regions, multiple association of chromosomes can be observed among diakenesis-metaphase I meiocytes (cytological screening).


Male Progeny Trans Location Translocation Heterozygote Dominant Lethal Spontaneous Frequency 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • W. M. Generoso
    • 1
  • B. Cattanach
    • 2
  • A. M. Malashenko
    • 3
  1. 1.Biology DivisionOak Ridge National LaboratoryOak RidgeUSA
  2. 2.MRC Radiology UnitHarwell, DidcotUK
  3. 3.Laboratory of Experimental Biological ModelsAcademy of Medical Sciences, U.S.S.R.MoscowUSSR

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