Abstract
“Normal” cells exposed to noxious agents which alter the cellular DNA will attempt to overcome this effect by excising portions of modified DNA and resynthesizing the correct sequence. The enzyme DNA polymerase has been implicated in this repair process (both in the repair replication step and the excision step in excision repair). It is to be expected, therefore, that cells lacking this repair enzyme will be more sensitive to the action of agents which react with cellular DNA. The availability of E. coli mutants (pol A1-) lacking this enzyme (1) has permitted verification of this prediction.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
De Lucia, P., and Cairns, J. Nature 224: 1164–1166 (1969).
Monk, M., Peacey, M., and Gross, J.D. J. Mol. Biol. 58: 623–630 (1971).
Gross, J., and Gross, M. Nature 224: 1166–1168 (1969).
Kanner, L., and Hanawalt, P. Biochem. Biophys. Res. Commun. 39.: 149–155, (1970).
Paterson, M. C., Boyle, J. M., and Setlow, R. B. J. Bacteriol. 107: 61–67 (1971).
Town, C. D., Smith, K. C., and Kaplan, H. S. Science 172: 851–854 (1971).
Mullinix, K P., and Rosenkranz, H. S. J. Bacteriol. 105: 565–572 (1971).
D’Alisa, R. M., Carden, G. A., III, Carr, H. S., and Rosenkranz, H. S. Mol. Gen. Genet. 110: 23–26 (1971).
Winshell, E. B., and Rosenkranz, H. S. J. Bacteriol. 104: 1168–1175 (1970).
Slater, E. E., Anderson, M. D., and Rosenkranz, H. S. Cancer Res. 31: 970–973 (1971).
Ames, B. N., McCann, J., and Yamasaki, E. Mutat. Res. 31: 347–364 (1975).
Rosenkranz, H. S., Gutter, B., and Speck, W. T. Mutat, Res. 41: 61–70 (1976).
Ichinotsubo, D., Mower, H. F., Setliff, J., and Mandel, M. Mutat. Res. 46: 53–62 (1977).
Rosenkranz, H. S., and McCoy, E. C., in preparation.
Fluck, E. R., Poirier, A., and Ruelius, H. W. Chem. Biol. Interactions 15: 219–231 (1976).
Longnecker, D. S., Curphey, T. J., James, S. T., Daniel, D. S. and Jacobs, N. J. Cancer Res. 34: 1658–1663 (1974).
Rosenkranz, H. S. Cancer Res. 33: 458–459 (1973).
Rosenkranz, H. S., McCoy, E. C., Anders, M., Speck, W. T., and Bickers, D. In: Application of Short-Term Bio ass ays in the Fractionation and Analysis of Complex Environmental Mixtures, Plenum Press, New York, 1979, pp. 3–42.
Bamford, D., Sorsa, M., Gripenberg, U., Laamanen, I., and Meretoja, T. Mutat. Res.40: 197–202 (1976).
Nagao, M., and Sugimura, T. Cancer Res. 32: 2369–2375 (1972).
Rosenkranz, H. S., and Poirier, L. A. J. Natl. Cancer Inst. 62: 873–892 (1979).
Ishii, Y., and Kondo, S. Mutat. Res. 27: 27–44 (1975).
Bridges, B. A., Mottershead, R. P., Green, M. H. L., and Gray, W. J. H. Mutat. Res. 19: 295–303 (1973).
Rosenkranz, H. S., and Carr, H. S. Antimicrob. Agents Chemotherapy 2: 376–372 (1972).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Plenum Press, New York
About this chapter
Cite this chapter
Rosenkranz, H.S. (1981). Mutagenicity of Selected Chemicals in Escherichia Coli DNA Repair Deficient Assays. In: De Serres, F.J., Shelby, M.D. (eds) Comparative Chemical Mutagenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3409-5_2
Download citation
DOI: https://doi.org/10.1007/978-1-4613-3409-5_2
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-3411-8
Online ISBN: 978-1-4613-3409-5
eBook Packages: Springer Book Archive