Skip to main content

Inborn Susceptibility/Resistance to Lung Cancer

  • Chapter
Cellular Biology of the Lung

Part of the book series: Ettore Majorana International Science Series ((SIOR,volume 1))

  • 93 Accesses

Abstract

The association between bronchial carcinoma and cigarette smoking is well known (Doll and Hill, 1952; 1964) but, while smokers carry a much higher risk of lung cancer than non-smokers, the majority of them escape this disease. A substantial variation in individual susceptibility to the carcinogenic effects of smoking must therefore be present in the population.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Allen, J.G., East, P.B., Francis, R.J. and Haigh, J.L., 1975, Metabolism of debrisoquine: identification of some urinary metabolites in rat and man. Drug Metab. Disp., 3: 332.

    Google Scholar 

  • Angelo, M., Dring, L.G., Lancaster, R., Latham, A. and Smith, R.L., 1975, The metabolism of debrisoquine in rat and man. Br. J. Pharmacol., 55: 264 P.

    Google Scholar 

  • Danhof, M., 1980, Antipyrine metabolite profile as a tool in the assessment of the activity of different drug oxidizing enzymes in man. Ph.D. Thesis, Univ. of Leiden.

    Google Scholar 

  • Doll, R. and Hill, A.B., 1952, A study of the aetiology of carcinoma of the lung, Br. Med. J., 2: 1271.

    Article  Google Scholar 

  • Ibid., 1964, Mortality in relation to smoking, Br. Med. J., 1: 1399.

    Google Scholar 

  • Evans, D.A.P., Mahgoub, A., Sloan, T.P., Idle, J.R. and Smith, R.L., 1980, A family and population study of the genetic polymorphism of debrmsoquine metabolism in a British White population, J. Med. Genet. 17: 102.

    Article  Google Scholar 

  • Idle, J.R., Mahgoub, A., Angelo, M.M., Dring, L.G., Lancaster, R. and Smith, R.L., 1979a, The metabolism of debrisoquine in man, Br. J. Clin, Pharmacol, 7: 257.

    Google Scholar 

  • Idle, J.R., Sloan, T.P., Smith, R.L. and Wakile, L.A., 1979b, The application of the phenotyped panel approach to the detection of polymorphism of drug oxidation in man. Br. J. Pharmacol., 66: 430 P.

    Google Scholar 

  • Idle, J.R. and Smith, R.L., 1979, Polymorphism of oxidation at carbon centres of drugs and their clinical significance, Drug Metab. Rev., 9: 301.

    Article  Google Scholar 

  • Kellerman, G., Kellerman, L.M. and Shaw, C.R., 1973a, Genetic variation of aryl hydrocarbon hydroxylase in human lymphocytes. Am. J. Hum. Genet. 25: 327.

    Google Scholar 

  • Kellerman, G., Shaw, C.R. and Kellerman, L.M., 1973b, Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma. N. Engl. J. Med. 289: 934.

    Article  Google Scholar 

  • Mahgoub, A., Idle, J.R., Dring, L.G., Lancaster, R. and Smith, R.L. 1977, Polymorphic hydroxylation of debrisoquine in man, Lancet, ii: 584.

    Article  Google Scholar 

  • Miller, J.A., 1974, in: “The induction of Drug metabolism, Symposia Medica Hoechst 14”, R.W. Estabrook, E. Lindenlaub, eds., Shattauer Verlag, Stuttgart-New York.

    Google Scholar 

  • Shah, R.R., Oates, N.S., Idle, J.R. and Smith, R.L., 1980, Genetic impairment of phenformin metabolism. Lancet i: 1147.

    Google Scholar 

  • Sloan, T.P., Mahgoub, A., Lancaster, R., Idle, J.R. and Smith, R.L. 1978, Polymorphism of carbon oxidation of drugs and clinical implications, Br. Med. J., 2: 655.

    Article  Google Scholar 

  • Wakile, L.A., Sloan, T.P., Idle, J.R. and Smith, R.L., 1979, Genetic evidence for the involvement of different oxidative mechanisms in drug oxidation. J. Pharm. Pharmacol. 31: 350.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Plenum Press, New York

About this chapter

Cite this chapter

Hetzel, M.R., Law, M., Keal, E.E., Sloan, T.P., Idle, J.R., Smith, R.L. (1982). Inborn Susceptibility/Resistance to Lung Cancer. In: Cumming, G., Bonsignore, G. (eds) Cellular Biology of the Lung. Ettore Majorana International Science Series, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3403-3_27

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-3403-3_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3405-7

  • Online ISBN: 978-1-4613-3403-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics