Zinc-Deficient Dwarfing

  • Hossain A. Ronaghy


The role of zinc as an essential micronutrient in animal life was not well established until recently. For the first time Todd et al. (1934) produced zinc deficiency in rats. The essential role of zinc in animal nutrition is through its effect as a metaloenzyme in the production of DNA-dependent RNA polymerase (Wacker and Vallee, 1959).


Placebo Zinc Nickel Albumin Chromium 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Chvapil, M. 1973, New aspects in the bioloical role of zinc: A stabilizer of macromolecules and biological membranes, Life Sci. 13: 1014.CrossRefGoogle Scholar
  2. Halsted, J. A., and Prasad, A. S., 1960, Syndrome of iron deficiency anemia—hepato-splenomegaly, hypogonadism, dwarfism, and geophagia, Trans. Am. Clin. Climatol. Assoc. 72: 130.Google Scholar
  3. National Academy of Sciences, 1970, Zinc in Human Nutrition, summary of Proceedings of a workshop, December, 1970, Food and Nutrition Board, NAS, Washington, D.C.Google Scholar
  4. Osis, D., Royston, K., Samachson, J., and Spencer, H., 1969, Atomic absorption spectrophotometry in mineral and trace-element studies in man Dev. Appl. Spectrosc. 7a: 227.Google Scholar
  5. Prasad, A. S., Miale, A., Farid, Z., Sandstead, H. H., Schulert, A. R., and Darby, W. J., 1963, Biochemical studies on dwarfism hypogonadism and anemia. Arch. Intern. Med. 111: 407.Google Scholar
  6. Prasad, A. S., Oberleas, D., Wolf, P., and Horwitz, J. P., 1967, Studies on zinc deficiency: Changes in trace elements and enzyme activities in tissues of zinc-deficient rats, J. Clin. Invest. 46: 549.CrossRefGoogle Scholar
  7. Ronaghy, H. A., Fox, M. R. S., Garn, S. M., Israel, H., Harp, A., Moe, P. G., and Halsted, J. A., 1969, Controlled zinc supplementation for malnourished school boys: A pilot experiment, Am. J. Clin. Nutr. 22: 1279.Google Scholar
  8. Scoular, F. I., 1939, A quantitative study, by means of spectrographic analysis, of zinc in nutrition, J. Nutr. 17: 103.Google Scholar
  9. Swenerton, H., and Hurley, L. S., 1968, Severe zinc deficiency in male and female rats, J. Nutr. 95: 8Google Scholar
  10. Todd, W. R., Elvejhem, C. A., and Hart, E. B., 1934, Zinc in the nutrition of the rat, Am. J. Physiol. 107: 146.Google Scholar
  11. Tribble, H. M., and Scoular, F. I., 1954, Zinc metabolism of young college women on self-selected diets, J. Nutr. 52: 209.Google Scholar
  12. Wacker, W. E. C., and Vallee, B. L., 1959, Nucleic acids and metals. I. Chromium, manganese, nickel, iron and other metals in ribonucleic acid from diverse biological sources, J. Biol. Chem. 234: 3257.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Hossain A. Ronaghy
    • 1
  1. 1.Trauma Medical ClinicSan DiegoUSA

Personalised recommendations