Progress in the Chemotherapeutic Treatment of Advanced Bladder Cancer

  • A Yagoda

Abstract

The introduction of cisplatin in 1976 (35) in the treatment of patients with transitional cell carcinoma of the urothelial tract, i.e. renal pelvis, ureter, bladder, urethra and prostatic ducts, has led to a systematic evaluation of chemotherapeutic agents for advanced bladder cancer. Disease-orientated phase II trials, some utilizing strict patient selection and response criteria, have confirmed cisplatin’s antitumor activity — 35% (27, 10, 39) and recently phase III prospectively randomized disease-orientated studies have been instituted. This paper will outline presently available data and discuss two recently completed trials at Memorial Sloan-Kettering Cancer Center which utilize methotrexate (38, 17) and vinblastine (1), each used singly.

Keywords

Oncol Methotrexate Cyclophosphamide Mitomycin Bleomycin 

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • A Yagoda
    • 1
  1. 1.Memorial Sloan-Kettering Cancer CenterNew YorkUSA

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