Mitochondrial Transport Systems
The specialized role of mitochondria in intermediary metabolism requires that only certain substrates, cofactors, and metals be accessible to their interior compartments. Of the substrates that must be capable of entering the matrix space, the most important are O2, H2O, ADP, phosphate, pyruvate, and fatty acids. At the same time, products of mitochondrial oxidations and phosphorylation must have a means of exiting from the organelle. These include CO2 and ATP. Virtually all mitochondria, irrespective of their source, have been shown to be either freely permeable or to have specific transport systems that accommodate an efficient passage of these essential metabolites across the permeability barriers separating the matrix space from the surrounding cytoplasm.
KeywordsLactate Respiration Succinate Carnitine Thiocyanate
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