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Advances in Solution Chemistry pp 231–251Cite as

The Composite Physical and Chemical Approach to the Solution Spatial Structure of Polypeptide Neurotoxins

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Abstract

The crucial details for the interpretation of spatial structures and intermolecular interactions of peptides and proteins could be revealed by proper combination of physical and chemical techniques. The paper presents the results of the combined approach for the evaluation of the conformation in solution of honey-bee venom component apamin (18 membered polypeptide), of three dimensional structure of Central Asian cobra neurotoxin II (61 amino acid residues), and of the topography of its binding site with acetylcholine receptor Torpedo Marmorata.

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Author information

Authors and Affiliations

  1. Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, GSP-1, Moscow, 117988, USSR

    V. F. Bystrov, V. T. Ivanov, V. V. Okanov, A. I. Miroshnikov, A. S. Arseniev, V. I. Tsetlin & V. S. Pashkov

  2. Institute of Biochemistry, S-75123, Uppsala, Sweden

    E. Karlsson

Authors
  1. V. F. Bystrov
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  2. V. T. Ivanov
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  3. V. V. Okanov
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  4. A. I. Miroshnikov
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  5. A. S. Arseniev
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  6. V. I. Tsetlin
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  7. V. S. Pashkov
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  8. E. Karlsson
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Editor information

Editors and Affiliations

  1. University of Florence, Florence, Italy

    I. Bertini  & A. Dei  & 

  2. University of Bologna, Bologna, Italy

    L. Lunazzi

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© 1981 Plenum Press, New York

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Bystrov, V.F. et al. (1981). The Composite Physical and Chemical Approach to the Solution Spatial Structure of Polypeptide Neurotoxins. In: Bertini, I., Lunazzi, L., Dei, A. (eds) Advances in Solution Chemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3225-1_17

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  • DOI: https://doi.org/10.1007/978-1-4613-3225-1_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3227-5

  • Online ISBN: 978-1-4613-3225-1

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