Histone Synthesis in Preimplantation Mouse Embryos
Recent advances in biochemical technology allow more detailed examination of gene expression during cleavage development of the mammalian embryo. As nuclear proteins are so obviously involved in embryonic activity at this time, a study of the expression and metabolism of these proteins (particularly the histones) should prove valuable in elucidating genetic regulatory mechanisms in mammalian development.
KeywordsHistone Marker Histone Gene Histone Variant Preimplantation Mouse Embryo Research Grant Committee
- Franklin, S. G., and Zweidler, A., 1977, Non-allelic variants of histones 2a, 2b and 3 in mammals. Science 266: 273.Google Scholar
- Newrock, K. M., Alfageme, C. R., Nardi, R. V., and Cohen, L. H., 1977, Histone changes during chromatin remodelling in embryogenesis. Cold Spring Harbor Symp. Quant. Biol. 42: 421.Google Scholar