Experimental Animal Models for Anaerobic Infections
The role of obligate anaerobes in serious infection has received increasing attention over the past several years. Initially, little was known about many of these microbes except that they were commonly found in certain infections and that they were the dominant components of the colonic microflora. Clinical studies often failed to document the pathogenic role of anaerobes because they were usually found in combination with aerobes at infected sites. Subsequent research has employed animal models to determine the pathogenic potential of anaerobic bacteria. This approach is particularly attractive because, unlike clinical studies, the investigations can be conducted under controlled conditions.
KeywordsAbscess Formation Experimental Animal Model Capsular Polysaccharide Barium Sulfate Viable Cell Density
Unable to display preview. Download preview PDF.
- 1.Altemeier, W.A. 1942. The pathogenicity of the bacteria of appendicitis. Surgery. 11: 374–384.Google Scholar
- 2.Benvenisk, R. and J. Davies. 1973. Mechanism of antibiotic resistance, Ann. Rev. Biochem. 42: 495–497.Google Scholar
- 3.Blair, J.E. 1970. E.H. Lennette and J.P. Truant (ed.). Manual of clinical microbiology. American Society for Microbiology, Bethesda, Maryland.Google Scholar
- 4.Cato, E.P., and J.L. Johnson. 1976. Reinstatement of species rank for Bacteroides fragilis, B. ovatus, JB. distasonis, B. thetaiotaomicron and B. vulgatus: designation of neotype strains for Bacteroides fragilis (Veillon and Zuber) Castellani and Chalmers and Bacteroides thetaiotaomicron (Distaso) Castellani and Chalmers. Int. J. Syst. Bacterid. 26: 230–237.CrossRefGoogle Scholar
- 6.Hill, G.B., S. Osterhout, and C. Pratt. 1974. Liver abscess production by non-sporeforming anaerobic bacteria in a mouse model. Infect. Immun. 9: 559–603.Google Scholar
- 8.Holdeman, L.V., E.P. Cato, and W.E.C. Moore (ed.). 1977. Anaerobe laboratory manual, 4th ed. Virginia Polytechnic Institute and State University, Blacksburg.Google Scholar
- 16.Meieney, F.L. 1931. Bacterial synergy in disease process. Ann. Surg. 44: 961–981.Google Scholar
- 17.Onderdonk, A.B., W.M. Weinstein, N.M. Sullivan, J.G. Bartlett, and S.L. Gorbach. 1974. Experimental intraabdominal abscess in rats; Quantitative bacteriology of infected animals. Infect, and Immun. 10: 1256–1259.Google Scholar
- 18.Onderdonk, A.B., J.G. Bartlett, T.J. Louie, N. Sullivan-Sigler, and S.L. Gorbach. 1976. Microbial synergy in experimental intraabdominal abscess. Infect, and Immun. 13: 22–26.Google Scholar
- 22.Weinstein, W.M., A.B. Onderdonk, J.G. Bartlett, and S.L. Gorbach. 1974. Experimental intraabdominal abscesses in rats: Development of an animal model. Infect, and Immun. 10: 1250–1259.Google Scholar
- 24.Willis, A.T., C.L. Bullen, I.R. Ferguson, P.H. Jones, K.D. Phillips, P.V. Tearle, K. Williams, S.E.J. Young, G.C. Brentnall, G.H. Bancroft-Livingstone, S.A. Seligman, J. Abrahams, A. Collyer, C. Lush, and D. Wilkenson. 1974. Metronidazole in the prevention and treatment of Bacteroides infections in gynecological patients. Lancet 2: 1540–1545.Google Scholar