The role of obligate anaerobes in serious infection has received increasing attention over the past several years. Initially, little was known about many of these microbes except that they were commonly found in certain infections and that they were the dominant components of the colonic microflora. Clinical studies often failed to document the pathogenic role of anaerobes because they were usually found in combination with aerobes at infected sites. Subsequent research has employed animal models to determine the pathogenic potential of anaerobic bacteria. This approach is particularly attractive because, unlike clinical studies, the investigations can be conducted under controlled conditions.
KeywordsAbscess Formation Experimental Animal Model Capsular Polysaccharide Barium Sulfate Viable Cell Density
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