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Aleutian Disease of Mink: A Model for Persistent Infection

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Comprehensive Virology

Abstract

Mink (Mustela vison) are members of the order Carnivora and family Mustelidae (Ewer, 1973). Other generally familiar members of the family include the wolverine, marten, badger, fisher, ferret, weasel, skunk, and otter. Mink are raised in large numbers on ranches for their valuable fur. The animals mate once a year in the early spring, and an average of four kits are born after a 50-day gestation period. The kits are usually weaned at 6–8 weeks of age and reach adult size at 7 months of age, at which time all except the breeding stock are sacrificed for their pelts on commercial ranches.

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References

  • An, S. H., and Ingram, D. G., 1977, Detection of inapparent Aleutian disease virus infection in mink, Am. J. Vet. Res. 38: 1619.

    PubMed  CAS  Google Scholar 

  • Bloom, M. E., 1976, Aleutian disease of mink: Production of 14C-labeled antiviral antibodies by mink lymphoid cells in vitro, Infect. Immun. 13: 281.

    CAS  Google Scholar 

  • Bloom, M. E., Race, R. E., Hadlow, W. J., and Chesebro, B., 1975, Aleutian disease of mink: The antibody response of sapphire and pastel mink to Aleutian disease virus, J. Immunol. 115: 1034.

    PubMed  CAS  Google Scholar 

  • Burger, D., Gorham, J. R., and Leader, R. W., 1965, Some physical and chemical characteristics of partially purified Aleutian disease virus, in: Slow, Latent, and Temperate Virus Infections (D. C. Gajdusek, C. J. Gibbs, and M. Alpers, eds.), pp. 307–313, NINDB Monograph No. 2, U.S. Government Printing Office, Washington, D.C.

    Google Scholar 

  • Burger, D., Srironganathan, N., and Gorham, J. R., 1978, Detection of antibody and antigen in Aleutian disease virus infected mink with enzyme-linked immunosorbent assay (ELISA), Abstr. Annu. Meet. Am. Soc. Microbiol. 1978: 65.

    Google Scholar 

  • Cheema, A., Henson, J. B., and Gorham, J. R., 1972, Aleutian disease of mink. Prevention of lesions by immunosuppression, Am. J. Pathol. 66: 543.

    PubMed  CAS  Google Scholar 

  • Chesebro, B., Bloom, M., Hadlow, W., and Race, R., 1975, Purification and ultrastructure of Aleutian disease virus of mink, Nature (London) 254: 456.

    CAS  Google Scholar 

  • Cho, H. J., 1977, Demonstration of heavy and light density populations of Aleutian disease virus, Can. J. Comp. Med. 41: 215.

    PubMed  CAS  Google Scholar 

  • Cho, H. J., and Greenfield, J., 1978, Eradication of Aleutian disease of mink by eliminating positive counterimmunoelectrophoresis reactors, J. Clin. Microbiol. 7: 18.

    PubMed  CAS  Google Scholar 

  • Cho, H. J., and Ingram, D. G., 1972, Antigen and antibody in Aleutian disease in mink. I. Precipitation reaction by agar-gel electrophoresis, J. Immunol. 108: 555.

    PubMed  CAS  Google Scholar 

  • Cho, H. J., and Ingram, D. G., 1973a, Isolation, purification and structure of Aleutian disease virus by immunological techniques, Nature (London) New Biol. 243: 174.

    CAS  Google Scholar 

  • Cho, H. J., and Ingram, D. G., 1973b, Antigen and antibody in Aleutian disease in mink. II. The reaction of antibody with the Aleutian disease agent using immunodiffusion and immunoelectroosmophoresis, Can. J. Comp. Med. 37: 217.

    PubMed  CAS  Google Scholar 

  • Cho, H. J., and Ingram, D. G., 1974, The antigen and virus of Aleutian disease in mink, J. Immunol. Methods 4: 217.

    Article  PubMed  CAS  Google Scholar 

  • Cochrane, C. G., and Hawkins, D., 1968, Studies on circulating immune complexes. III. Factors governing the ability of circulating complexes to localize in blood vessels, J. Exp. Med. 127: 137.

    Article  PubMed  CAS  Google Scholar 

  • Crawford, T. B., McGuire, T. C., Porter, D. D., and Cho, H. J., 1977, A comparative study of detection methods for Aleutian disease viral antibody, J. Immunol. 118: 1249.

    PubMed  CAS  Google Scholar 

  • Drommer, W., and Trautwein, G., 1975, Die pathogenese der Aleutenkrankheit der nerze. VII. Chronische hepatitis mit gallengangproliferation, Vet. Pathol. 12: 77.

    PubMed  CAS  Google Scholar 

  • Eklund, C. M., Hadlow, W. J., Kennedy, R. C., Boyle, C. C., and Jackson, T. A., 1968, Aleutian disease of mink. Properties of the etiologic agent and the host responses, J. Infect. Dis. 118: 510.

    Article  PubMed  CAS  Google Scholar 

  • Ewer, R. F., 1973, The Carnivores, Cornell University Press, Ithaca.

    Google Scholar 

  • Gerell, R., 1970, Home ranges and movements of the mink Mustela vision Schreber in southern Sweden, Oikos 21: 160.

    Article  Google Scholar 

  • Gierloff, B., and Thordal-Christensen, A., 1975, Aleutiansyge hos mink. Studie over infektionens forekomst og betygning ved pavisning af specifikt antistof v.h.a. modstrOselektroforese, Dan. Vet. Tidsskr. 58: 589.

    Google Scholar 

  • Gorham, J. R., Leader, R. W., and Henson, J. B., 1964, The experimental transmission of a virus causing hypergammaglobulinemia in mink: Sources and modes of infection, J. Infect. Dis. 114: 341.

    Article  PubMed  CAS  Google Scholar 

  • Gorham, J. R., Henson, J. B., Crawford, T. B., and Padgett, G. A., 1976, The epizootiology of Aleutian disease, in: Slow Virus Diseases of Animals and Man ( R. H. Kimberlin, ed.), pp. 135–158, North-Holland, Amsterdam.

    Google Scholar 

  • Goudas, P., Karstad, L., and Tabel, H., 1970, Ultraviolet inactivation of the infective agent of Aleutian disease of mink, Can. J. Comp. Med. 34: 118.

    PubMed  CAS  Google Scholar 

  • Greenfield, J., Walton, R., and MacDonald, K. R., 1973, Detection of Aleutian disease in mink: Serum-plate agglutination using iodine compared with precipitation by agar-gel electrophoresis, Res. Vet. Sci. 15: 381.

    PubMed  CAS  Google Scholar 

  • Haagsma, J., 1969, A study about the resistance of Aleutian disease agent against chemical and physical influences as to control the disease, Tijdschr. Diergeneeskd. 94: 824.

    Google Scholar 

  • Hahn, E. C., Ramos, L., and Kenyon, A. J., 1977, Expression of Aleutian mink disease antigen in cell culture, Infect. Immun. 15: 204.

    PubMed  CAS  Google Scholar 

  • Hartsough, G. R., and Gorham, J. R., 1956, Aleutian disease in mink, Natl. Fur News 28: 10.

    Google Scholar 

  • Helmboldt, C. F., and Jungherr, E. L., 1958, The pathology of Aleutian disease in mink, Am. J. Vet. Res. 19: 212.

    PubMed  CAS  Google Scholar 

  • Henson, J. B., Gorham, J. R., Leader, R. W., and Wagner, B. M., 1962, Experimental hypergammaglobulinemia in mink, J. Exp. Med. 116: 357.

    Article  PubMed  CAS  Google Scholar 

  • Henson, J. B., Leader, R. W., Gorham, J. R., and Padgett, G. A., 1966, The sequential development of lesions in spontaneous Aleutian disease of mink, Pathol. Vet. 3: 289.

    Article  PubMed  CAS  Google Scholar 

  • Henson, J. B., Gorham, J. R., and Padgett, G. A., 1969, Pathogenesis of the glomerular lesions in Aleutian disease of mink: Immunofluorescent studies, Arch Pathol. 87: 21.

    PubMed  CAS  Google Scholar 

  • Henson, J. B., Gorham, J. R., McGuire, T. C., and Crawford, T. B., 1976, Pathology and pathogenesis of Aleutian disease, in: Slow Virus Diseases of Animals and Man ( R. H. Kimberlin, ed.), pp. 175–205, North-Holland, Amsterdam.

    Google Scholar 

  • Ingram, D. G., and Cho, H. J., 1974, Aleutian disease in mink: Virology, immunology and pathogenesis, J. Rheumatol. 1: 74.

    PubMed  CAS  Google Scholar 

  • Johnson, M. I., Henson, J. B., and Gorham, J. R., 1975, The influence of genotype on the development of glomerular lesions in mink with Aleutian disease virus. A correlated light, fluorescent, and electron microscopic study, Am. J. Pathol. 81: 321.

    PubMed  CAS  Google Scholar 

  • Karstad, L., and Pridham, T. J., 1962, Aleutian disease of mink. I. Evidence of its viral etiology, Can. J. Comp. Med. 26: 97.

    PubMed  CAS  Google Scholar 

  • Kenyon, A. J., 1966, Immunologic deficiency in Aleutian disease of mink, Am. J. Vet. Res. 27: 1780.

    PubMed  CAS  Google Scholar 

  • Kenyon, A. J., Helmboldt, C. F., and Nielsen, S. W., 1963, Experimental transmission of Aleutian disease with urine, Am. J. Vet. Res. 24: 1066.

    PubMed  CAS  Google Scholar 

  • Kenyon, A. J., Gander, J. E., Lopez, C., and Good, R. A., 1973, Isolation of Aleutian mink disease virus by affinity chromatography, Science 179: 187.

    Article  PubMed  CAS  Google Scholar 

  • Larsen, A. E., 1965, Electrophoresis, I AT and the elusive Aleutian disease, Natl. Fur News 37: 18.

    Google Scholar 

  • Larsen, A. E., 1969, Immunological and viral studies of Aleutian disease in mink, Ph.D. Dissertation, University of Utah.

    Google Scholar 

  • Larsen, A. E., and Porter, D. D., 1975, Pathogenesis of Aleutian disease of mink: Identification of nonpersistent infections, Infect. Immun. 11: 92.

    PubMed  CAS  Google Scholar 

  • Lodmell, D. L., Hadlow, W. J., Munoz, J. J., and Whitford, H. W., 1970, Hemagglutinin antibody response of normal and Aleutian disease-affected mink to keyhole limpet hemocyanin, J. Immunol. 104: 878.

    PubMed  CAS  Google Scholar 

  • Malien, M. S., Ugalde, E. L., Balcazar, M. R., Bolivar, J. I., and Meyran, S., 1950, Precipitation of abnormal serums by Lugol’s solution, Am. J. Clin. Pathol. 20: 39.

    Google Scholar 

  • McGuire, T. C., Crawford, T. B., Henson, J. B., and Gorham, J. R., 1971, Aleutian disease of mink: Detection of large quantities of complement-fixing antibody to viral antigens, J. Immunol. 107: 1481.

    PubMed  CAS  Google Scholar 

  • McKay, D. G., Phillips, L. L., Kaplan, H., and Henson, J. B., 1967, Chronic intravascular coagulation in Aleutian disease of mink, Am. J. Pathol. 50: 899.

    PubMed  CAS  Google Scholar 

  • Myers, M., Laughlin, C., De La Maza, L. M., and Carter, B., 1978, Adeno-associated virus type 2 defective interfering particles, Abstr. Annu. Meet. Am. Soc. Microbiol. 1978: 229.

    Google Scholar 

  • Obel, A.-L., 1959, Studies on a disease in mink with systemic proliferation of the plasma cells, Am. J. Vet. Res. 20: 384.

    Google Scholar 

  • Padgett, G. A. Gorham, J. R., and Henson, J. B., 1967, Epizootiologic studies of Aleutian disease. I. Transplacental transmission of the virus, J. Infect. Dis. 117: 35.

    Article  PubMed  CAS  Google Scholar 

  • Pan, I. C., Tsai, K. S., and Karstad, L., 1970, Glomerulonephritis in Aleutian disease of mink: Histological and immunofluorescence studies, J. Pathol. 101: 119.

    Article  PubMed  CAS  Google Scholar 

  • Perryman, L. E., Banks, K. L., and McGuire, T. C., 1975, Lymphocyte abnormalities in Aleutian disease virus infection of mink: Decreased T lymphocyte responses and increased B lymphocyte levels in persistent viral infection, J. Immunol. 115: 22.

    PubMed  CAS  Google Scholar 

  • Porter, D. D., and Larsen, A. E., 1964, Statistical survey of Aleutian disease in ranch mink, Am. J. Vet. Res. 25: 1226.

    PubMed  CAS  Google Scholar 

  • Porter, D. D., and Larsen, A. E., 1967, Aleutian disease of mink: Infectious virus-antibody complexes in the serum, Proc. Soc. Exp. Biol. Med. 126: 680.

    Google Scholar 

  • Porter, D. D., and Larsen, A. E., 1968, Virus-host interactions in Aleutian disease of mink, Perspect. Virol. 6: 173.

    Google Scholar 

  • Porter, D. D., and Larsen, A. E., 1974, Aleutian disease of mink, Prog. Med. Virol. 18: 32.

    PubMed  CAS  Google Scholar 

  • Porter, D. D., Dixon, F. J., and Larsen, A. E., 1965a, The development of a myelomalike condition in mink with Aleutian disease, Blood 25: 736.

    PubMed  CAS  Google Scholar 

  • Porter, D. D., Dixon, F. J., and Larsen, A. E., 19656, Metabolism and function of gamma globulin in Aleutian disease of mink, J. Exp. Med. 121: 889.

    Google Scholar 

  • Porter, D. D., Larsen, A. E., and Porter, H. G., 1969, The pathogenesis of Aleutian disease of mink. I. In vivo viral replication and the host antibody responses to viral antigen, J. Exp. Med. 130: 575.

    Article  PubMed  CAS  Google Scholar 

  • Porter, D. D., Larsen, A. E., and Porter, H. G., 1972, The pathogenesis of Aleutian disease of mink. II. Enhancement of tissue lesions following the administration of a killed virus vaccine or passive antibody, J. Immunol. 109: 1.

    PubMed  CAS  Google Scholar 

  • Porter, D. D., Larsen, A. E., and Porter, H. G., 1973, The pathogenesis of Aleutian disease of mink. III. Immune complex arteritis, Am. J. Pathol. 71: 331.

    PubMed  CAS  Google Scholar 

  • Porter, D. D., Larsen, A. E., Cox, N. A., Porter, H. G., and Suffin, S. C., 1977a, Isolation of Aleutian disease virus of mink in cell culture, Interviology 8: 129.

    Article  CAS  Google Scholar 

  • Porter, D. D., Larsen, A. E., and Porter, H. G., 19776, Reduced severity of lesions in mink infected transplacental with Aleutian disease virus, J. Immunol. 119: 872.

    Google Scholar 

  • Porter, D. D., Porter, H. G., and Larsen, A. E., 1977c, Immunoglobulin class of Aleutian disease viral antibody, Fed. Proc. 36: 1268 (abstr.).

    Google Scholar 

  • Portis, J. L., and Coe, J. E., 1978, Predominant glomerular deposition of IgA and C in Aleutian disease of mink, Fed. Proc. 37: 1558 (abstr.).

    Google Scholar 

  • Preble, O. T., and Youngner, J. S., 1975, Temperature-sensitive viruses and the etiology of chronic and inapparent infections, J. Infect. Dis. 131: 467.

    Article  PubMed  CAS  Google Scholar 

  • Rhode, S. L., Ill, 1978, Defective interfering particles of parvovirus HI, J. Virol. 27: 347.

    CAS  Google Scholar 

  • Rose, J. A., 1974, Parvovirus reproduction, in: Comprehensive Virology, Vol. 3 ( H. Fraenkel-Conrat and R. R. Wagner, eds.), pp. 1–61, Plenum Press, New York.

    Google Scholar 

  • Shahrabadi, M. S., and Cho, H. J., 1977, Detection and localization of Aleutian disease virus and its antigens in vivo by immunoferritin technique, Can. J. Comp. Med. 41: 435.

    PubMed  CAS  Google Scholar 

  • Shahrabadi, M. S., Cho, H. J., and Marusyk, R. G., 1977, Characterization of the protein and nucleic acid of Aleutian disease virus, J. Virol. 23: 353.

    PubMed  CAS  Google Scholar 

  • Tabel, H., and Ingram, D. G., 1970a, Dialysis experiments with the infectious agent of Aleutian disease of mink, Arch. Gesamte Virusforsch. 32: 53.

    Article  PubMed  CAS  Google Scholar 

  • Tabel, H., and Ingram, D. G., 19706, The immunoglobulins in Aleutian disease (viral plasmacytosis) of mink. Different types of hypergammaglobulinemias, Can. J. Comp. Med. 34: 329.

    Google Scholar 

  • Tabel, H., Ingram, D. G., and Fletch, S. M., 1970, Natural antibodies in sera of mink before and after the development of Aleutian disease (viral plasmacytosis), Can. J. Comp. Med. 34: 320.

    PubMed  CAS  Google Scholar 

  • Trautwein, G. W., and Helmboldt, C. F., 1962, Aleutian disease of mink. I. Experimental transmission of the disease, Am. J. Vet. Res. 23: 1280.

    PubMed  CAS  Google Scholar 

  • Trautwein, G., Schneider, P., and Ernst, E., 1974, Urtersuchugen liber die Pathogenese der Aleutenkrankheit der Nerze. VIII. Depression der Antikorperbildung gegen Meerrettichperoxydase, Zbl. Vet. Med. 5 21: 467.

    Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, University of California School of Medicine, Los Angeles, California, 90024, USA

    David D. Porter

  2. Animal Diseases Research Institute (Western), Agriculture Canada, Lethbridge, Alberta, T1J 3Z4, Canada

    H. J. Cho

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  1. David D. Porter
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  2. H. J. Cho
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Editors and Affiliations

  1. Department of Molecular Biology and Virus Laboratory, University of California, Berkeley, California, USA

    Hein Fraenkael-Conrat

  2. Department of Microbiology, University of Virginia, Charlottesville, Virginia, USA

    Robert R. Wagner

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© 1980 Plenum Press, New York

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Porter, D.D., Cho, H.J. (1980). Aleutian Disease of Mink: A Model for Persistent Infection. In: Fraenkael-Conrat, H., Wagner, R.R. (eds) Comprehensive Virology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3129-2_5

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  • DOI: https://doi.org/10.1007/978-1-4613-3129-2_5

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