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Current Status of in Vitro Fertilization and Reimplantation

  • Melvin L. Taymor

Abstract

The birth of baby Louise Brown in July 1978 was truly a dramatic event. Although it was the result of many years of intensive research, the event itself was a milestone in man’s ability to work with nature. To some, in vitro fertilization and reimplantation represents a Pandora’s box of “brave new world” reproduction: of oocyte donors and rental wombs. To others, it means a future chance, and I emphasize future and chance, of parenthood for the thousands of women who are sterile because of irrevocably damaged Fallopian tubes.

Keywords

Granulosa Cell Fallopian Tube Follicular Fluid Human Oocyte Oocyte Donor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Baker, T. G., Oogenesis and ovarian development, in: Reproductive Biology (H. Balin and S. R. Glasser, eds.), p. 378, Excerpta Medica, Amsterdam (1972).Google Scholar
  2. 2.
    Pincus, G., and Enzman, E. V., The comparative behavior of mammalian eggs in-vivo and in-vitro I. The activation of ovarian eggs, J. Exp. Med. 62: 665 (1935).PubMedCrossRefGoogle Scholar
  3. 3.
    Pincus, G., and Saunders, B., Unfertilized human tubal ova, Anat. Rec. 69: 163 (1939).Google Scholar
  4. 4.
    Edwards, R. G., Studies in human conception, Am. J. Obstet. Gynecol. 117: 587 (1973).PubMedGoogle Scholar
  5. 5.
    Ortiz, M. E., and Croxalto, H. B., Observations on transport, aging, and development of ova in the human genital tract, in: Recent Advances in Reproduction and Regulation of Fertility (G. P. Talwar, ed.), p. 307, Elsevier, Amsterdam (1979).Google Scholar
  6. 6.
    Shettles, L. B., Further observations on living human oocytes and ova, Am. J. Obstet. Gynecol. 69: 365 (1955).PubMedGoogle Scholar
  7. 7.
    Edwards, R. G., Donahue, R. P., Baraink, T. A., et al., Preliminary attempts to fertilize oocytes matured in-vitro, Am. J. Obstet. Gynecol. 76: 192 (1966).Google Scholar
  8. 8.
    Jagiello, G., Karnicki, J., and Ryan, R. J., Superovulation with pituitary gonadotropins, Lancet 1: 178 (1968).CrossRefGoogle Scholar
  9. 9.
    Edwards, R. G., Bavister, B. D., and Steptoe, P. L., Early stages of fertilization in-vitro of human oocytes matured in-vivo, Nature 221: 632 (1969).PubMedCrossRefGoogle Scholar
  10. 10.
    Edwards, R. G., Steptoe, P. L., and Purdy, J. M., Fertilization and cleavage in-vitro of preovulatory human oocytes, Nature 227: 1307 (1970).PubMedCrossRefGoogle Scholar
  11. 11.
    Steptoe, P. L., and Edwards, R. G., Reimplantation of a human embryo with subsequent tubal pregnancy, Lancet 1: 880 (1976).PubMedCrossRefGoogle Scholar
  12. 12.
    Steptoe, P. L., and Edwards, R. G., Birth after the reimplantation of a human embryo, Lancet 2: 36 (1978).Google Scholar
  13. 13.
    Steptoe, P. L., and Edwards, R. G., Report to the Royal College of Obstetricians and Gynecologists, January 26, 1979.Google Scholar
  14. 14.
    Leridan, H., Démographie des échers de la reproduction, in: Les Accidents Chromosomiques de la Repro-duction (A. Borie and C. Thibeault, eds.), p. 13, Centre International de L’Enfance, Paris (1973).Google Scholar
  15. 15.
    Biggers, J. D., In-vitro fertilization, embryo culture, and embryo transfer in the human, Report to Ethics Advisory Committee, Department of Health, Education and Welfare, p. 41, September 15 (1978).Google Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Melvin L. Taymor
    • 1
    • 2
  1. 1.Harvard Medical SchoolBostonUSA
  2. 2.Division of Infertility and Reproductive EndocrinologyBeth Israel HospitalBostonUSA

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