Thiocystine, bis-[2-amino-2-carboxyethyl]trisulfide, is a relatively stable trisulfide analog of cystine. The compound was first isolated by Fletcher and Robson1 from hydrochloric acid hydrolysates of proteins which are rich in cystine. The trisulfide and a small amount of accompanying tetrasulfide were artefacts produced by acid- catalyzed exchange reactions between cystine and its decomposition products. Sandy et al.2 isolated thiocystine, the trisulfide of glutathione, and the corresponding mixed trisulfide between glutathione and cysteine from Rhodopseudomonas spheroides. Also, Massey et al.3 detected the presence of the trisulfide of glutathione in commercial samples of the compound.
KeywordsLipoic Acid Iodoacetic Acid Sulfane Sulfur Mercaptosuccinic Acid COOH COOH COOH
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