Adjuvant Chemotherapy Following Primary Irradiation in T3 Bladder Cancer

  • B Richards
  • Yorkshire Urological Cancer Research Group
Part of the Ettore Majorana International Science Series book series (EMISS, volume 1)

Summary

This paper presents the early survival figures of a study designed to evaluate the toxicity of Adriamycin and 5-Fluorouracil combined with irradiation in the primary treatment of T3 bladder cancer. Fifteen of 18 patients survived one year. These results are better than would be expected. Adjuvant chemotherapy in T3 bladder cancer deserves further evaluation.

Keywords

Toxicity Unal Adriamycin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Cross, J. R., Glashan, R. W., Humphrey, C. S., Robinson, M. R. G., Smith, P. H. and Williams, R. E., Treatment of advanced bladder cancer with Adriamycin and 5-Eluorouracil. Brit. J. Urol. 48, 609–615 (1976).PubMedCrossRefGoogle Scholar
  2. 2.
    De Kernion, J. B., The chemotherapy of advanced bladder carcinoma. Cancer Res. 37, 2771–2774 (1977).Google Scholar
  3. 3.
    Glashan, R. W., Houghton, A. L., Robinson, M. R. G., A toxicity study of the treatment of T3 bladder tumours with a combination of radiotherapy and chemotherapy. Brit. J. Urol. 49, 669–672 (1977).PubMedCrossRefGoogle Scholar
  4. 4.
    Prout, G. R., The role of surgery in the potentially curative treatment of bladder cancer. Cancer Res. 37, 2764–2770 (1977).PubMedGoogle Scholar
  5. 5.
    Rider, W. D. and Evans, D. H., Radiotherapy in the treatment of recurrent bladder cancer. Brit. J. Urol. 48, 595–601 (1976).PubMedCrossRefGoogle Scholar
  6. 6.
    Wallace, D. M. and Bloom, H. J. G., Management of deeply- infiltrating (T3) bladder carcinoma: controlled trial of radical radiotherapy versus pre-operative radiotherapy and radical cystectomy. Brit. J. Urol. 48, 587–594 (1976).PubMedCrossRefGoogle Scholar
  7. 7.
    Wajsman, C., Merrin, C., Moore, R. and Murphy, G. P., Current results from treatment of bladder tumours with total cystectomy at Roswell Park Memorial Institute. J. Urol. 113, 806–810 (1975).PubMedGoogle Scholar
  8. 8.
    Whitmore, W. F., Batata, M. A., Ghoneim, M. A., Grabstald, H., and Unalj A. Radical cystectomy with or without prior irradiation in the treatment of bladder cancer. J. Urol. 118, 184–187 (1977).PubMedGoogle Scholar
  9. 9.
    Whitmore, W. F., Batata, M. A., Hilaris, B. S., Reddy, G. N., Unal, A., Ghoneim, M. A., Grabstald, H., and Chu, F. A comparative study of two preoperative radiation regimens with cystectomy for bladder cancer. Cancer 40, 1077–1086 (1977).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • B Richards
    • 1
  • Yorkshire Urological Cancer Research Group
    • 1
  1. 1.York District HospitalYorkEngland

Personalised recommendations