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Mass Spectrometric Characterization of Sydnocarb ® and its Major Metabolites in Rat

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Book cover Recent Developments in Mass Spectrometry in Biochemistry and Medicine

Abstract

Sydnocarb, N-phenylcarbamoyl-3-(ß-phenylisopropyl)-sydnonimine (1) is a new psychostimulator. From earlier examinations it was established (1) that the effect of sydnocarb on the central nervous system, e.g. as compared to that of Amphetamine, develops more gradually, lasts longer and the therapeutic doses do not cause euphoria or locomotor excitation. Studies concerning the pharmacokinetics of sydnocarb in rat have been carried out using sydnocarb labelled with 14C at various positions (2, 3), but no report on metabolic fate of this drug has appeared in literature.

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References

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Author information

Authors and Affiliations

  1. Hungarian Academy of Sciences, Budapest, Hungary

    J. Tamás & G. Czira

  2. Gedeon Richter Ltd., Budapest, Hungary

    M. Polgár & L. Vereczkey

Authors
  1. J. Tamás
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  2. M. Polgár
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  3. G. Czira
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  4. L. Vereczkey
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Editor information

Editors and Affiliations

  1. “Mario Negri” Institute, Milan, Italy

    Alberto Frigerio

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© 1979 Plenum Press, New York

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Tamás, J., Polgár, M., Czira, G., Vereczkey, L. (1979). Mass Spectrometric Characterization of Sydnocarb ® and its Major Metabolites in Rat. In: Frigerio, A. (eds) Recent Developments in Mass Spectrometry in Biochemistry and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3018-9_4

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  • DOI: https://doi.org/10.1007/978-1-4613-3018-9_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3020-2

  • Online ISBN: 978-1-4613-3018-9

  • eBook Packages: Springer Book Archive

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