Abstract
The indoleamine Serotonin (5-hydroxytryptamine) is presently considered as one of the few established central neurotransmitters, its metabolism having been related to physiological functions of the body as well as several psychiatric disorders, such as schizophrenia and depression. Consequently, various analytical methods have been developed for serotonin (5HT) as well as for its precursor tryptophan (TP) and its acidic metabolite, 5-hydroxyindole- -3-acetic acid (5HIAA) in brain tissue (1–3).
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References
W.D. Denkla and H.K. Dewey, J. Lab. Clin. Med., 1967, 69, 160.
G. Curzon and A.R. Green, Br. J. Pharmacol., 1970, 39, 653.
O. Beck, F.A. Wiesel and G. Sedvall, J. Chromatogr., 1977, 134, 407.
W.R. Martin and J.W. Sloan, Psychopharmacologia, 1970, 18, 231.
S.R. Philips, D.A. Durden and A.A. Boulton, Can. J. Biochem., 1974, 52, 447.
J.M. Saavedra and J. Axelrod, J. Pharmacol. Exp. Ther., 1972, 182, 363.
S.R. Snodgrass and A.S. Horn, J. Neurochem., 1973, 21, 687.
W.R. Martin, J.W. Sloan, S.T. Christian and T.H. Clements, Psychopharmacologia, 1972, 24, 331.
J.J. Warsh, D.D. Godse, H.C. Stancer, P.W. Chan and D.V. Coscina Biochem. Med., 1977,18 10.
J.J. Warsh, P.W. Chan, D.D. Godse, D.V. Coscina and H.C. Stancer J. Neurochem., 1977,.29, 955.
J. Segura, J. Veiguela and E. Gelpí, in preparation.
F. Artigas, E. Gelpí, M. Prudencio, J.A. Alonso and J. Ballart, Anal. Chem., 1977, 49, 543.
F. Artigas and E. Gelpi, Anal. Biochem., in press.
E. Gelpi, E. Peralta and J. Segura, J. Chromatogr. Sei., 1974, 12, 701.
J. Segura, F. Artigas, E. Martínez and E. Gelpi, Biomed. Mass Spectrom., 1976, 3 91•
A.A. Boulton and G.B. Baker, J. Neurochem., 1975, 25, 477.
L. Bertilsson and L. Palmer, Science, 1972, 177, 74.
S.J. Dencker, V. Malm, B.E. Roos and B. Werdinius, J. Neurochem., 1966, 13, 1545.
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© 1979 Plenum Press, New York
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Artigas, F., Gelpí, E. (1979). Concurrent Extraction and GC-MS Assay of Endogenous TP, T, IAA, 5HT and 5HIAA in Single Rat Brain Samples. In: Frigerio, A. (eds) Recent Developments in Mass Spectrometry in Biochemistry and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3018-9_26
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DOI: https://doi.org/10.1007/978-1-4613-3018-9_26
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