Abstract
Some findings indicate that cadaverine and its acylated metabolites monoacetylcadaverine and monopropionylcadaverine may be associated with schizophrenia. Monoacetylcadaverine and monopropionylcadaverine were isolated from urine of schizophrenic patients (1). It was speculated that their presence in the urine may reflect an abnormal metabolism of cadaverine concomitant with mental illness (2). We have reported recently that the blood concentrations of acylated cadaverines are significantly increased in schizophrenic patients in comparison to those in nonschizophrenic subjects (3).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
T. H. Perry, S. Hansen, L. MacDougall, Nature, 1967, 214, 484.
M. Stepita-Klauco, H. Dolezalova, Nature, 1974, 252, 158.
H. Dolezalova, M. Stepita-Klauco, J. Kucera, in “Mass Spectrometry in Drug Metabolism”, A. Frigerio and L. Ghisalberti, Eds., Plenum, New York, 1977, p. 201.
S. I. Harik, G.W. Pasternak, S. H. Snyder, in “Polyamines in Normal and Neoplastic Growth”, D. Rüssel, Ed., Raven Press, New York, 1973, p. 307.
H. Tabor, C.W. Tabor, Adv. Enzymol. Mol. Biol., 1972, 36, 203.
F. Dreyfuss, R. Chayen, G. Dreyfuss, Israel J. Med. Sci., 1975, 11, 785.
H. Dolezalova, M. Stepita-Klauco and R. Fairweather, Brain Res., 1974, 77, 166.
H. Dolezalova and M. Stepita-Klauco, Adavances in Mass Spectrometry in Biochemistry and Medicine, 1976, 1, 206.
S. Henningsson, L. Persson and E. Rosengren, Acta Physiol. Scand 1976, 86, 445.
F. Picolli and A. Lajtha, Biochim. Biophys. Acta, 1971, 225, 356
M.W. Miller and M. Stepita-Klauco, Society for Neuroscience Abstracts, 1977, 3, 446.
American Psychiatric Association, “DSM-II Diagnostic and Statistical Manual of Mental Disorders”, 2nd., Washington, D.C., 1968.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1979 Plenum Press, New York
About this chapter
Cite this chapter
Dolezalova, H., Stepita-Klauco, M., van der Velde, C., Cassone, V. (1979). An Assay for Schizophrenia: Mass Spectrometry Determination of Two Cadaverine Metabolites. In: Frigerio, A. (eds) Recent Developments in Mass Spectrometry in Biochemistry and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3018-9_21
Download citation
DOI: https://doi.org/10.1007/978-1-4613-3018-9_21
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-3020-2
Online ISBN: 978-1-4613-3018-9
eBook Packages: Springer Book Archive