Mass Fragmentographic Quantification of Phosphonoacetic Acid in the Blood of Monkeys Infected with Herpesvirus Saimiri
Herpesvirus Saimiri° was isolated from a degenerating squirrel monkey kidney culture in 1968 (1). HVS induces leukemia and/or lymphoma when inoculated into a variety of nonhuman primates (2). The induced lymphoma appears to be analogous to those involved in EBV and Burkitt’s lymphoma in humans, thus it is a good model for evaluating antiviral agents used alone or in combination with chemoimmunotherapy. In 1973 it was reported that phosphoacetic acid (PAA) and its disodium salt has an inhibitory effect on the in vitro and/or in vivo replication of several DNA-containing viruses which are assumed to be oncogenic, including HVS (3, 4). PAA inhibits the synthesis of late viral products by interfering with the activity of virus-associated DNA polymerase (5).
KeywordsMultiple Infusion PHOSPHONOACETIC Acid Chemical Ionization Source Expect Concentration Range Normal Pool Serum
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