Red Cell Choline and Affective Disease

  • I. Hanin


It is fascinating, from a historical point of view, to trace the progression of the clinical significance which has been attributed throughout the past 50 years to the role of acetylcholine (ACh) in a variety of centrally mediated disease states. The identity and involvement of ACh in neurotransmitter function have been known to investigators for over five decades. Nevertheless, a concrete understanding of the contribution of ACh to various central nervous system mediated disease states has been persistently elusive over this time span, although indirect evidence has accumulated which has implicated that activation of cholinergic mechanisms may generally be responsible for induction of behavioral suppression and reduction in affect (Rowntree et al., 1950; Pfeiffer and Jenney, 1957; Van Andel, 1959; Gershon and Shaw, 1961; Bowers et al., 1964;Collard et al., 1965; Modestin et al., 1973; Tamminga et al., 1976). Only recently, with the development of a number of other neurotransmitter-related hypotheses for psychiatric disease states, has there also been a serious attempt to implicate ACh in certain types of affective and neurologic disorders. Specifically, Janowsky and his coinvestigators, within the past several years, have been instrumental in directly promoting the concept that ACh may, indeed, play an important role in the etiology of affective disorders (Janowsky et al., 1972; 1974; See also Davis and Janowsky, and Janowsky et al., this book).


Tardive Dyskinesia Paroxysmal Nocturnal Hemoglobinuria Cholinergic Activity Cholinergic Mechanism Affective Disease 
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • I. Hanin
    • 1
  1. 1.Department of Psychiatry, Western Psychiatric Institute and ClinicUniversity of Pittsburgh School of MedicinePittsburghUSA

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