Abstract
Administration of the acetylcholinesterase inhibitor physostigmine to man produces a range of behavioral changes that can be of therapeutic benefit to some patients with Huntington’s disease, tardive dyskinesia, mania and memory deficits (Aquilonius and Sjostrom, 1971; Janowsky et al, 1973; Klawans and Rubovits, 1974; Davis et al., 1976; 1978a; 1978b). The scope and complexity of the actions of physostigmine suggest that the neurochemical basis of these effects might extend beyond the ability of the drug to increase cholinergic activity. It is possible that some of the behavioral consequences of physostigmine result from the action of increased central cholinergic activity on other neurotransmitters.
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References
Aghajanian, G. K., and Bunney, B. S., 1973, Central dopaminergic neurons: Neurophysiological identification and response to drugs, in “Frontiers in Catecholamine Research” ( E. Usdin, and S. Snyder, eds.), pp. 643–648, Pergamon Press, New York.
Anden, N. E., 1974, Effect of oxotremorine and physostigmine on the turnover of dopamine in the corpus striatum and limbic system, J. Pharm. Pharmacol 26: 738.
Anden, N. E., and Bedard, P., 1971, Influences of cholinergic mechanisms on the function and turnover of brain dopamine, J. Pharm. Pharmacol 23: 460.
Anden, N. E., and Stock, G., 1973, Effect of clozapine on the turnover of dopamine in the corpus striatum and in the limbic system, J. Pharm. Pharmacol 25: 346.
Anfred, T., and Randrup, A., 1968, Cholinergic mechanisms in brain inhibiting amphetamine-induced stereotyped behavior, Acta Pharmacol Toxicol 26: 384.
Aquilonius, S. M., and Sjostrom, R., 1971, Cholinergic and dopaminergic mechanisms in Huntington’s chorea, Life Set 70: 405.
Baldessarini, R. J., and Tarsy, D., 1976, Mechanisms underlying tardive dyskinesia, in “The Basal Ganglia” (M. D. Yahr, ed.), pp. 433–446, Raven Press, New York.
Bartholini, G., Stadler, H., and Lloyd, F. G., 1973, Cholinergic-dopaminergic interactions in the extrapyramidal system, Adv. Neurol 3: 233.
Bartholini, G., Keller, H. H., and Pletscher, A., 1975, Drug-induced changes of dopamine turnover in striatum and limbic system of the rat, J. Pharm. Pharmacol 27: 439.
Bartholini, G., Keller, H. H., and Pletscher, A., 1975, Drug-induced changes of dopamine turnover in striatum and limbic system of the rat, J. Pharm. Pharmacol 27: 439.
Bhatnagar, S. P, 1973, Studies related to the cholinergic influence on the accumulation and disappearance of monoamines in the rat brain, Can. J. Physiol. Pharmacol 51: 893.
Bowers, M. B., and Roth, R. H., 1972, Interactions of atropine-like drugs with dopamine-containing neurones in rat brain, Br. J. Pharmacol 44: 301.
Carlsson, A., Kehr, W., Lindquist, M., Magnusson, T., and Atack, C. U., 1972, Regulation of monoamine metabolism in the central nervous system, Pharmacol Rev. 24: 311.
Cools, A. R., 1977, Two functionally and pharmacologically distinct dopamine receptors in the rat brain, in “Advances in Biochemical Psychopharmacology, Vol 16” ( E. Costa, and G. L. Gessa, eds.), pp. 215–225, Raven Press, New York.
Cools, A. R., Honig, W. M. M., Pijnenburg, A. J. J., and van Rossom, J. M., 1976, The nucleus accumbens of rats and dopaminergic mechanisms regulating locomotor behavior, Neurosci. Lett. 3: 335.
Corrodi, H., Fuxe, K., Hammer, W., et al, 1967, Oxotremorine and central monoamine neurones, Life Sci 6:2557.
Corrodi, H., Fuxe, K., and Lidbrink, P., 1972, Interaction between cholinergic and catecholaminergic neurones in rat brain, Brain Res. 43: 397.
Crossman, A. R., Walker, R. J., and Woodruff, G. N., 1974, Proceedings: Pharmacological studies on single neurones in the substantia nigra, Br. J. Pharmacol 57. 137 P.
Davis, K. L., Hollister, L. E., Barchas, J. D., and Berger, P. A., 1976, Choline in tardive dyskinesia and Huntington’s disease, Life Sci. 19: 1507.
Davis, K. L., Hollister, L. E., Goodwin, F. K., and Gordon, E. K., 1977, Neurotransmitter metabolites in the cerebrospinal fluid of man following physostigmine, Life Sci 21: 933.
Davis, K. L., Berger, P. A., Hollister, L. E., and DeFraites, E. G., 1978a, Physostigmine in mania, Arch. Gen. Psychiatry 35(1): 119.
Davis, K. L., Mohs, R., Tinklenberg, J. R., Pfefferbaum, A., Hollister, L. E., and Kopell, B. S., 1978b, Physostigmine: improvement of long-term memory processes in normal humans, Science 201: 4352.
Davis, K. L., Hollister, L. E., and Tepper, J., 1978c, Cholinergic inhibition of methyl- phenidate induced stereotypy: oxotremorine,Psychopharmacology 56: 1.
Davis, K. L., Hollister, L. E., Vento, A. L., and Simonton, S., 1978d, Choline chloride in methylphenidate- and apomorphine-induced stereotypy, Life Sci. 22: 2171.
Feltz, P., 1971, Gamma-aminobutyric acid and a caudate-nigral inhibition, Can. J. Physiol. Pharmacol. 49: 1113.
Giorguieff, M. F., Lefloch, M. L., Westfall, T. C., Glowinski, J., and Besson. M. J., 1976, Nicotinic effect of acetylcholine on the release of newly synthesized H dopamine in rat striatal slices and cat caudate nucleus, Brain Res. 106: 117.
Groves, P. M., Wilson, C. J., Young, S. J., and Rebec, G. V., 1975, Self-inhibition by dopa-minergic neurons: an alternative to the “Normal Feedback Loop” hypothesis for the mode of action of certain psychotropic drugs, Science 190: 522.
Janowsky, D. S., El-Yousef, M. K., Davis, J. M., and Sekerke, H. J., 1972, Cholinergic antagonism of methylphenidate-induced stereotyped behavior, Psychopharmacologia 27: 295.
Janowsky, D. S., El-Yousef, J. K., and Davis, J. M., 1973, Parasympathetic suppression of manic-symptoms by physostigmine, Arch. Gen. Psychiatry 28: 542.
Javoy, F., Agid, Y., Bouvet, D., et al., 1974, Changes in neostriatal dopamine metabolism after carbachol or atropine microinjections into the substantia nigra, Brain Res. 68: 253.
Javoy, F., Agid, Y., and Glowinski, J., 1975, Oxotremorine and atropine-induced changes of dopamine metabolism in the rat brain, J. Pharm. Pharmacol. 27: 611.
Karoum, F., Gillin, J. C., Wyatt, R. J., and Costa, E., 1975, Mass fragmentography of nanogram quantities of biogenic amine metabolites in human cerebrospinal fluid and whole rat brain, Biomed. Mass. Spectrom. 2: 183.
Kessler, J. A., Gordon, E. K., Reid, J. L., and Kopin, I. J., 1976, Homovanillic acid and 3-methoxy, 4-hydroxyphenylethyleneglycol production by the monkey spinal cord, J. Neurochem. 26: 1057.
Klawans, H. L., 1970, A pharmacologic analysis of Huntington’s chorea, Eur. Neurol 4: 148.
Klawans, H. L., and Rubovits, R., 1974, Effect of cholinergic and anticholinergic agents on tardive dyskinesia, J. Neurol Neurosurg. Psychiatry 37: 941.
Laverty, R., and Sharman, D. F., 1965, Modification by drugs of the metabolism of 3, 4-dihydroxyphenylethylamine, noradrenaline, and 5-hydroxytryptamine in the brain, Br. J; Pharmacol 24: 159.
McGeer, P. A., Fibiger, H. C., Haitoris, T., Singh, V. K., McGeer, E. G., and Maler, L., 1974, Biochemical neuroanatomy of the basal ganglia, Adv. Behav. Biol. 10: 21.
McNair, J. L., Sutin, J., and Tsubokawa, T., 1972, Suppression of cell firing in the substantia nigra by caudate nucleus stimulation, Exp. Neurol 37: 395.
Murrin, L. C., and Roth, R. H., 1976, Dopaminergic neurons: reversal of effects elicited by gamma-butyrolactone by stimulation of the nigra-neostriatal pathway, Naunyn Schmiedebergs Arch. Pharmacol 295: 15.
Nauta, W. J. H., and Mehler, W. R., 1966, Projections of the lentiform nucleus in the monkey, Brain Res. 1: 3.
Niimi, K., Ikeda, T., Kawamura, S., and Inoshita, H., 1970, Efferent projections of the head of the caudate nucleus in the edit, Brain Res. 27: 327.
Nose, T., and Takemoto, H., 1974, Effect of oxotremorine on homovanillic acid concen-tration in striatum of the rat. Eur. J. Pharmacol 25: 51.
Okada, V., and Hassler, R., 1973, Uptake and release of 7-aminobutyric acid (GABA)in slices of substantia nigra of rat, Brain Res. 49: 214.
O’Keefe, R., Shapman, D. R., and Vogt, M., 1970, Effect of drugs used in psychoses on cerebral dopamine metabolism, Br. J. Pharmacol 38: 281.
Papeschi, R., Sourkes, T. L., Piorier, L. J., and Boucher, R. L., 1971, On the intracerebral origin of homovanillic acid of the cerebrospinal fluid of experimental animals, Brain Res. 28: 521.
Perez-Cruet, J., Gessa, G. L., Taliamonte, A., et al., 1971, Evidence for a balance in the basal ganglia between cholinergic and dopaminergic activity, Fed. Proc. 30:216.
Portig, P. J., and Vost, M., 1969, Release into the cerebral ventricles of substances with possible transmitter function in the caudate nucleus, J. Physiol (Lond)204: 681.
Post, R. M., Goodwin, R. K., Gordon, E., and Watkin, D., 1973, Amine metabolites in human cerebrospinal fluid: effects of cord transection and spinal fluid block, Science 179: 891.
Precht, W., and Yoshida, M., 1971, Blockage of caudate-evoked inhibition of neurons in the substantia nigra by Picrotoxin, Brain Res. 32: 229.
Roffler-Tarlov, S., Sharman, D.F., and Tegerdine, P., 1971, 3-4-dihydroxyphenylacetic acid in the mouse striatum: a reflection of intra- and extra-neuronal metabolism of dopamine? J. Pharmacol 42: 343.
Roth, R. H., Walters, J. R., and Aghajanian, G. K., 1973, Effect of impulse flow on the release and synthesis of dopamine in the rat striatum, in “Frontiers in Catecholamine Research” ( E. Usdin, and S.H. Snyder, eds.), pp. 567–574, Pergamon Press, New York.
Roth, R. H., Murrin, L. C., and Walter, J. R., 1976, Central dopaminergic neurons: effects of alterations in impulse flow on the accumulation of dihydroxyphenylace tic acid, Eur. J. Pharmacol 36: 163.
Roth, R. H., Salzman, P. M., and Nowycky, M. C., 1978, Impulse flow and short-term regulation of transmitter biosynthesis in central catecholaminergic neurons, in “Psychopharmacology: A Generation of Progress” (M.A. Lipton, A. Dimascio, and K.F. Killam, eds.), pp. 185–198, Raven Press, New York.
Swahn, C. G., Sandgarde, B., Wiesel, F. A., and Sedvall, G., 1976, Simultaneous determination of the three major monoamine metabolites in brain tissue and body fluids by a mass fragmentographic method, Psychopharmacology 48: 141.
Szabo, J., 1962, Topical distribution of the striatal efferents in the monkey, Exp. Neurol 5: 21.
Szabo, J., 1970, Projections from the body of the caudate nucleus in the rhesus monkey, Exp. Neurol 27: 1.
Szabo, J., 1972, The course and distribution of efferents from the tail of the caudate nucleus in the monkey, Exp. Neurol 57: 562.
Voneida, T. J., 1960, An experimental study in the course and destination of fibers arising in the head of caudate nucleus in the cat and monkey, J. Comp. Neurol 115: 15.
Walters, J. R., 1972, Effect of gamma hydroxybutyrate on dopamine and dopamine metabolites in the rat striatum, Biochem. Pharmacol 21: 2 111.
Westernick, B. H. C., and Korf, J., 1975, Influence of drugs on striatal and limbic homovanillic acid concentration in the rat brain, Eur. J. Pharmacol 33: 31.
Yoshida, M., and Precht, W., 1971, Monosynaptic inhibition of neurons of the substantia nigra by caudato-nigral fibers, Brain Res. 32: 215.
Yoshida, M., Rabin, A., and Anderson, M., 1971, Two types of monosynaptic inhibition of pallidal neurons produced by stimulation of the diencephalon and substantia nigra, Brain Res. 30: 235.
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© 1979 Plenum Press, New York
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Davis, K.L., Faull, K.F., Hollister, L.E., Barchas, J.D., Berger, P.A. (1979). Physostigmine Related Changes in Cerebrospinal Fluid Neurotransmitter Metabolites in Man. In: Davis, K.L., Berger, P.A. (eds) Brain Acetylcholine and Neuropsychiatric Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2934-3_25
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DOI: https://doi.org/10.1007/978-1-4613-2934-3_25
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