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Evidence for the Existence of Two Striatal Dopamine Receptors

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Brain Acetylcholine and Neuropsychiatric Disease

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Abstract

Striatal dopaminergic mechanisms have been implicated in two separate human neurologic syndromes. The first of these is parkinsonism; a syndrome consisting of rigidity, akinesia, resting tremor and loss of postural reflexes which is felt to be related to decreased activity of dopamine (DA) at striatal DA receptors (Hornykiewicz, 1966; Klawans, 1973). The second is chorea which is felt to reflect increased dopaminergic activity at at least some striatal DA receptors (Klawans, 1971; Klawans, 1973).

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Author information

Authors and Affiliations

  1. Department of Neurological Sciences, Rush Presbyterian St. Luke’s Medical Center, 1725 West Harrison Street, Chicago, Illinois, 60612, USA

    H. L. Klawans, A. Hitri, P. A. Nausieda & W. J. Weiner

Authors
  1. H. L. Klawans
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  2. A. Hitri
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  3. P. A. Nausieda
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  4. W. J. Weiner
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Editor information

Editors and Affiliations

  1. Veterans Administration Hospital, Palo Alto, California, 94304, USA

    Kenneth L. Davis  & Philip A. Berger  & 

  2. Stanford University School of Medicine, Stanford, California, 94305, USA

    Kenneth L. Davis  & Philip A. Berger  & 

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© 1979 Plenum Press, New York

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Klawans, H.L., Hitri, A., Nausieda, P.A., Weiner, W.J. (1979). Evidence for the Existence of Two Striatal Dopamine Receptors. In: Davis, K.L., Berger, P.A. (eds) Brain Acetylcholine and Neuropsychiatric Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2934-3_24

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  • DOI: https://doi.org/10.1007/978-1-4613-2934-3_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-2936-7

  • Online ISBN: 978-1-4613-2934-3

  • eBook Packages: Springer Book Archive

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