Skip to main content
SpringerLink
Log in
Book cover

Complex Carbohydrates of Nervous Tissue pp 327–345Cite as

Complex Carbohydrates of Secretory Organelles

  • Chapter

Abstract

Over the last few years, considerable attention has been devoted to the role played by complex carbohydrates in the structure and function of secretory granules and vesicles. These intracellular storage organelles, which are delimited by a single membrane, are endowed with the ability to discharge their content into the extracellular space by exocytosis. Since each secretory system is characterized by the specificity of its secretion products, the various granules and vesicles constitute an extremely heterogenous family of organelles. In some of them, complex carbohydrates represent secretion products of known physiological significance. This is the case, for instance, with the gonadotropin and thyrotropin granules of the anterior pituitary, the B granules of follicular thyroid cells, and the immunoglobulin vesicles of plasmocytes. Other secretory granules (e.g., those of the exocrine pancreas, parotid gland, and liver) contain a mixture of many physiologically important secretion products, some of which are complex carbohydrates. Finally, in a variety of other systems, the occurrence of complex carbohydrates (often in small amounts) in the segregated content of secretory organelles has also been reported, even if no clear information is yet available on whether these components have any function after their discharge. However, complex carbohydrates do not reside only in the content of secretory organelles, since in all systems so far investigated they have also been found in the limiting membrane, where at least some of them are oriented according to a specific geometry.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aborg, C. H., Fillion, G., Nosal, R., and Uvnas, B., 1972, A sulphomucopolysaccharide-protein complex in the adrenergic vesicle (granule) fraction from nerves and tissues, Acta Physiol Scand. 86: 427.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, P., Slorach, S. A., and Uvnas, B., 1974,5-HT storage in rat and rabbit blood platelets: The separation of ATP-containing and sulphomucopolysaccharide-containing granules, Acta Physiol Scand. 90:522.

    Article  PubMed  CAS  Google Scholar 

  • Aunis, D., Bouclier, M., Pescheloche, M., and Mandel, P., 1977, Properties of membrane-bound dopamine hydroxylase in chromaffin granules from bovine adrenal medulla, J. Neurochem. 29: 439.

    Article  PubMed  CAS  Google Scholar 

  • Autuori, F., Svensson, H., and Dallner, G., 1975, Biogenesis of microsomal membrane glycoprotein in rat liver. II. Purification of soluble glycoproteins and their incorporation into microsomal membranes, J. Cell Biol. 67: 700.

    Article  PubMed  CAS  Google Scholar 

  • Baggiolini, M., Bretz, U., and Dewald, B., 1977, Biochemical and structural properties of the vacuolar apparatus of polymorphonuclear leukocytes, in: Movement, Metabolism and Bactericidal Mechanisms of Phagocytes ( F. Rossi, P. Patriarca, and D. Romeo, eds.), pp. 89–102, Piccin Medical Books, Padua.

    Google Scholar 

  • Bennett, G., and Leblond, C. P., 1977, Biosynthesis of the glycoproteins present in plasma membrane, lysosomes and secretory materials, as visualized by radioautography, Histochem. J. 9: 393.

    Article  PubMed  CAS  Google Scholar 

  • Berg, N. B., 1978, Sulfate metabolism in the exocrine pancreas. II. The production of sulfated macromolecules by the mouse exocrine pancreas, J. Cell Sci. 31: 199.

    PubMed  CAS  Google Scholar 

  • Berg, N. B., and Austin, B. P., 1976, Intracellular transport of sulfated macromolecules in parotid acinar cells, Cell Tissue Res. 165: 215.

    Article  PubMed  CAS  Google Scholar 

  • Berg, N. B., and Young, R. W., 1971, Sulfate metabolism in pancreatic acinar cells, J. Cell Biol. 50: 469.

    Article  PubMed  CAS  Google Scholar 

  • Bergeron, J. J. M., Evans, W. H., and Geschwind, I. I., 1973, Insulin binding to rat liver Golgi fractions, J. Cell Biol. 59: 771.

    Article  PubMed  CAS  Google Scholar 

  • Blaschke, E., Bergqvist, U., and Uvnas, B., 1976, Identification of the mucopolysaccharides in catecholamine-containing subcellular particle fractions from various rat, cat and ox tissues, Acta Physiol. Scand. 97: 110.

    Article  PubMed  CAS  Google Scholar 

  • Bretscher, M. S., 1973, Membrane structure: Some general principles, Science 181: 622.

    Article  PubMed  CAS  Google Scholar 

  • Castle, J. D., Jamieson, J. D., and Palade, G. E., 1975, Secretion granules of the rabbit parotid gland. Isolation, subfractionation and characterization of the membrane and content sub– fractions, J. Cell Biol. 64: 182.

    Article  PubMed  CAS  Google Scholar 

  • Ceccarelli, B., Clementi, F., and Meldolesi, J., (eds.), 1974, Cytopharmacology of Secretion, Raven Press, New York.

    Google Scholar 

  • Cook, G. M. W., 1977, Biosynthesis of plasma membrane proteins, in: The Synthesis, Assembly and Turnover of Cell Surface Components, ( G. Poste and G. L. Nicolson, eds.), pp. 85–136, Elsevier/North-Holland, Amsterdam.

    Google Scholar 

  • DaPrada, M., VonBerlepsch, K., and Pletscher, A., 1972, Storage of biogenic amines in blood platelets and adrenal medulla: Lack of evidence for direct involvement of glycosaminoglycans, Arch. Pharmacol. (New Ser.) 275: 315.

    Google Scholar 

  • Den, H., Kaufman, B., McGuire, E. J., and Roseman, S., 1975, The sialic acids. XVIII. Subcellular distribution of seven glycosyltransferases in embryonic chicken brain, J. Biol. Chem. 250: 739.

    PubMed  CAS  Google Scholar 

  • Dunn, W. B., and Spicer, S. S., 1969, Histochemical demonstration of sulfated mucosubstances and cationic proteins in human granulocytes and platelets, J. Histochem. Cytochem. 17: 668.

    Article  PubMed  CAS  Google Scholar 

  • Eagles, P. A. M., Johnson, L. N., and VanHorn, C., 1975, The distribution of concanavalin A receptor sites on the membrane of chromaffin granules, J. Cell Sci. 19: 33.

    PubMed  CAS  Google Scholar 

  • Eagles, P. A. M., Johnson, L. N., and VanHorn, C., 1976, The distribution of anionic sites on the surface of the chromaffin granule membrane, J. JJltrastruct. Res. 55: 87.

    Article  CAS  Google Scholar 

  • Farquhar, M. G., Bergeron, J. J. M., and Palade, G. E., 1974, Cytochemistry of Golgi fractions prepared from rat liver, Cell Biol. 60: 8.

    Article  CAS  Google Scholar 

  • Fillion, G., Nosal, R.,and Uvnas, B., 1971, The presence ofasulphomucopolysaccharide–protein complex in adrenal medullary cell granules, Acta Physiol. Scand. 84: 286.

    Google Scholar 

  • Flashner, Y., and Schramm, M., 1977, Retention of amylase in the secretory granules of parotid gland after extensive release of Ca++ by ionophore A-23187, J. Cell Biol. 74: 789.

    Article  PubMed  CAS  Google Scholar 

  • Freilich, L. S., Lewis, R. C., Reppucci, A. C., Jr., and Silbert, J. E., 1975, Glycosaminogly-

    Google Scholar 

  • can synthesizing activity of an isolated Golgi preparation from cultured mast cells, Biochem. Biophys. Res. Commun. 63:663.

    Google Scholar 

  • Gagnon, C., Schatz, R., Otten, U., and Thoenen, H., 1976, Synthesis, subcellular distribution and turnover of dopamine ß-hydroxylase in organ cultures of sympathetic ganglia and adrenal medulla, J. Neurochem. 27: 1083.

    Article  PubMed  CAS  Google Scholar 

  • Geissler, D., Martinek, A., Margolis, R. U., Margolis, R. K., Skrivanek, J. A., Ledeen, R., Konig, P., and Winkler, H., 1977, Composition and biogenesis of complex carbohydrates of ox adrenal chromaffin granules, Neuroscience 2: 685.

    Article  PubMed  CAS  Google Scholar 

  • Giannattasio, G., and Zanini, A., 1976, Presence of sulfated proteoglycans in prolactin secretory granules isolated from the rat pituitary gland, Biochim. Biophys. Acta 439: 349.

    PubMed  CAS  Google Scholar 

  • Giannattasio, G., Zanini, A., and Meldolesi, J., 1975, Molecular organization of rat prolactin granules. I. In vitro stability of intact and “membraneless” granules, J. Cell Biol. 64: 246.

    Google Scholar 

  • Giannattasio, G., Zanini, A., Rosa, P., Margolis, R. K., Margolis, R. U., and Meldolesi, J., 1979, Molecular organization of prolactin granules. III. Intracellular transport of glycosaminoglycans and glycoproteins of bovine prolactin granule matrix (in prep.).

    Google Scholar 

  • Haddad, A., Pelletier, G., Marchi, F., and Brasileiro, I. L. G., 1977, Light microscope radio- autographic study of glycoprotein secretion in the hypothalamic-neurohypophysial system of the rat after L-fucose-3H injection, Cell Tissue Res. 177: 67.

    PubMed  CAS  Google Scholar 

  • Hirano, H., Parkhouse, B., Nicolson, G. L., Lennox, E. S., and Singer, S. J., 1972, Distribution of saccharide residues on membrane fragments from a myeloma-cell homogenate: Its implications for membrane biogenesis, Proc. Natl. Acad. Sci. U.S.A. 69: 2945.

    Article  PubMed  CAS  Google Scholar 

  • Holtzman, E., 1977, The origin and fate of secretory packages, especially synaptic vesicles, Neuroscience 2: 327.

    Article  PubMed  CAS  Google Scholar 

  • Hopkins, C. R., 1975, Synthesis and secretion of a large glycoprotein in the pars intermedia, J. Endocrinol. 65: 225.

    Article  PubMed  CAS  Google Scholar 

  • Hortnagl, H., 1976, Membranes of the adrenal medulla: A comparison of membranes of chromaffin granules with those of the endoplasmic reticulum, Neuroscience 1: 9.

    Article  PubMed  CAS  Google Scholar 

  • Hortnagl, H., Winkler, H., and Lochs, H., 1972, Membrane proteins of chromaffin granules: Dopamine hydroxylase, a major constituent, Biochem. J. 129: 187.

    PubMed  CAS  Google Scholar 

  • Horwitz, A. L., and Dorfman, A., 1968, Subcellular sites for synthesis of chondromucoprotein of cartilage, J. Cell Biol. 38: 358.

    Article  PubMed  CAS  Google Scholar 

  • Howell, S. L., and Tyhurst, M., 1977, Distribution of anionic sites on surface of B cell granule and plasma membranes: A study using cationic ferritin, J. Cell Sci. 27: 289.

    PubMed  CAS  Google Scholar 

  • Howell, S. L., Tyhurst, M., Duvefelt, H., Andersson, A., and Hellerstrom, C., 1978, Role of zinc and calcium in the formation and storage of insulin in the pancreatic B-cell, Cell Tissue Res. 188: 107.

    Article  PubMed  CAS  Google Scholar 

  • Hvas, S., and Thorn, N. A., 1973, Hexosamine and heparin in homogenate and subcellular fractions from bovine neurohypophysis, Acta Endocrinol. 74: 209.

    PubMed  CAS  Google Scholar 

  • Jansson, S. E., 1970, Uptake of 5-hydroxytryptamine by mast cell granules in vitro, Acta Physiol. Scand. 82: 35.

    Article  Google Scholar 

  • Jacques, L. B., 1975, The mast cells in the light of new knowledge of heparin and sulfated mucopolysaccharides, Gen. Pharmacol. 6: 235.

    Article  Google Scholar 

  • Jones, C. W., and Swann, R. W., 1975, A glycoprotein in the neurosecretory granules of the neurohypophysis, J. Physiol. (London) 245: 45 P.

    Google Scholar 

  • Kiang, W.-L., Crockett, C. P., Margolis, R. K.,and Margolis, R. U., 1978, Glycosaminoglycans and glycoproteins associated with microsomal subfractions of brain and liver, Biochemistry 17: 3841.

    Article  PubMed  CAS  Google Scholar 

  • Konig, P., Hortnagl, H., Kostron, H., Sapinsky, H., and Winkler, H., 1976, The arrangement of dopamine hydroxylase (EC 1.14.2.1) and chromomembrin B in the membrane of chromaffin granules, J. Neurochem. 27: 1539.

    Article  PubMed  CAS  Google Scholar 

  • Kronquist, K. E., Elmahdy, A., and Ronzio, R. A., 1977, Synthesis and subcellular distribution of heparan sulfate in the rat exocrine pancreas, Arch. Biochem. Biophys. 182: 188.

    Article  PubMed  CAS  Google Scholar 

  • Lagercrantz, H., 1976, On the composition and function of large dense-cored vesicles in sympathetic nerves, Neuroscience 1: 81.

    Article  PubMed  CAS  Google Scholar 

  • Lagunoff, D., 1974, Analysis of dye binding sites in mast cell granules, Biochemistry 13: 3982.

    Article  PubMed  CAS  Google Scholar 

  • Lagunoff, D., and Pritzl, P., 1976, Characterization of rat mast cell granule proteins, Arch. Biochem. Biophys. 173: 554.

    Article  PubMed  CAS  Google Scholar 

  • Lalli, M. F., and Clermont, Y., 1975, Leydig cells and their role in the synthesis and secretion of glycoproteins, Anat. Rec. 181: 403.

    Google Scholar 

  • Ledeen, R. W., Skrivanek, J. A., Tirri, L. J., Margolis, R. K., and Margolis, R. U., 1976, Gangliosides of the neuron: Localization and origin, in: Ganglioside Function: Biochemical and Pharmacological Implications ( G. Porcellati, B. Ceccarelli, and G. Tettamanti, eds.), pp. 83–103, Plenum Press, New York.

    Google Scholar 

  • Little, J. S., and Widnell, C. C., 1975, Evidence for the translocation of 5-nucleotidase across hepatic membranes in vitro, Proc. Natl. Acad. Sci. U.S.A. 72: 4013.

    Article  PubMed  CAS  Google Scholar 

  • Margolis, R. K., Jaanus, S. D., and Margolis, R. U., 1973, Stimulation of acetylcholine of sulfated mucopolysaccharide release from the perfused cat adrenal gland, Mol. Pharmacol. 9: 590.

    PubMed  CAS  Google Scholar 

  • Margolis, R. K., Margolis, R. U., Preti, C., and Lai, D., 1975A, Distribution and metabolism of glycoproteins and glycosaminoglycans in subcellular fractions of brain, Biochemistry 14:4797.

    Google Scholar 

  • Margolis, R. K., Preti, C., Chang, L., and Margolis, R. U., 1975B, Metabolism of the protein moiety of brain glycoproteins, J. Neurochem. 25:707.

    Google Scholar 

  • Margolis, R. U., and Margolis, R. K., 1973, Isolation of chondroitin sulfate and glycopeptides from chromaffin granules of adrenal medulla, Biochem. Pharmacol. 22: 2195.

    Article  PubMed  CAS  Google Scholar 

  • Margolis, R. U., and Margolis, R. K., 1977, Metabolism and function of glycoproteins and glycosaminoglycans in nervous tissue, Int. J. Biochem. 8: 85.

    Article  CAS  Google Scholar 

  • Matthews, E. K., Evans, R. J., and Dean, P. M., 1972, The ionogenic nature of the secretory-granule membrane: Electrokinetic properties of isolated chromaffin granules, Biochem. J. 130: 825.

    PubMed  CAS  Google Scholar 

  • Meldolesi, J., 1974, Secretory mechanisms in pancreatic acinar cells: Role of the cytoplasmic membranes, in: Cytopharmacology of Secretion ( B. Ceccarelli, F. Clementi, and J. Meldolesi, eds.), pp. 71–85, Raven Press, New York.

    Google Scholar 

  • Meldolesi, J., Jamieson, J. D., and Palade, G. E., 1971, Composition of cellular membranes in the pancreas of the guinea pig. II. Lipids, J. Cell Biol. 49: 130.

    Article  PubMed  CAS  Google Scholar 

  • Meldolesi, J., Borgese, N., De Camilli, P., and Ceccarelli, B., 1978, Cytoplasmic membranes and the secretory process, in: Cell Membrane Fusion ( G. Poste and G. L. Nicolson, eds.), pp. 509–627, Elsevier/North-Holland, Amsterdam.

    Google Scholar 

  • Meyer, D. I., and Burger, M. M., 1976, The chromaffin granule surface localization of carbohydrate on the cytoplasmic surface of an intracellular organelle, Biochim. Biophys. Acta 443: 428.

    Article  PubMed  CAS  Google Scholar 

  • Morgan, I. G., Zanetta, J. G., Breckenridge, W. G., Vincendon, G., and Gombos, G., 1973, The chemical structure of synaptic membranes, Brain Res. 62: 405.

    Article  PubMed  CAS  Google Scholar 

  • Morre, D. J., 1978, The Golgi apparatus and membrane biogenesis, in: Membrane Fusion ( G. Poste and G. L. Nicolson, eds.), pp. 1–83, Elsevier/North-Holland, Amsterdam.

    Google Scholar 

  • Morrissey, J. J., Hamilton, J. W., and Cohn, D. V., 1978, The secretion of parathormone and glycosylated proteins by parathyroid cells in culture, Biochem. Biophys. Res. Commun. 82: 1279.

    Article  PubMed  CAS  Google Scholar 

  • Nakagami, K., Warshawsky, H., and Leblond, C. P., 1971, The elaboration of protein and carbohydrate by rat parathyroid cells as revealed by electron microscope radioautography, J. Cell Biol. 51: 596.

    Article  PubMed  CAS  Google Scholar 

  • Nelson, D. L., Harden, T. K., and Molinoff, B., 1978, Adrenergic storage vesicles in rat heart: Quantitation of membrane-bound and membrane-enclosed dopamine hydroxylase, J. Pharmacol. Exp. Ther. 205: 357.

    PubMed  CAS  Google Scholar 

  • Nicolson, G. L., and Singer, S. J., 1974, The distribution and asymmetry of mammalian cell surface saccharides utilizing ferritin conjugated plant agglutinins as specific saccharide stains, Proc. Natl. Acad. Sci. U.S.A. 68: 942.

    Article  Google Scholar 

  • Noseworthy, J., Smith, G. H., Himmelhoch, S. R.,and Evans, W. H., 1975, Protein and glycoprotein electrophoretic patterns of enriched fractions of primary and secondary granules from guinea pig polymorphonuclear leukocytes, J. Cell Biol. 65: 577.

    CAS  Google Scholar 

  • Olsson, I., 1969, Intracellular transport of glycosaminoglycans (mucopolysaccharides) in human leukocytes, Exp. Cell Res. 54: 318.

    Article  PubMed  CAS  Google Scholar 

  • Palade, G. E., 1975, Intracellular aspects of the process of protein secretion, Science 189: 347.

    Article  PubMed  CAS  Google Scholar 

  • Pelletier, G., 1971, Detection des glycoproteines dans les cellules corticotropes de l’hypophysedu rat, J. Microsc. 11: 327.

    CAS  Google Scholar 

  • Pelletier, G., 1974, Autoradiographic studies of synthesis and intracellular migration of glycoproteins in the rat anterior pituitary gland, J. Cell Biol. 62: 185.

    Article  PubMed  CAS  Google Scholar 

  • Pfenninger, K. H., and Maylie-Pfenninger, M. F., 1977, Localized appearance of new lectin receptors on the surface of growing neurites, J. Cell Biol. 75: 54a.

    Google Scholar 

  • Pletscher, A., Da Prada, M., Berneis, K. H., Steffen, H., Lutold, B., and Weder, H. G., 1974, Molecular organization of amine storage organelles of blood platelets and adrenal medulla, in: Cytopharmacology of Secretion ( B. Ceccarelli, F. Clementi, and J. Meldolesi, eds.), pp. 257–264, Raven Press, New York.

    Google Scholar 

  • Pycock, C., Blaschke, E., Bergqvist, U., and Uvnas, B., 1975, On the possible involvement of sulphomucopolysaccharides in the storage of catecholamines within the central nervous system, Acta Physiol. Scand. 95: 373.

    Article  PubMed  CAS  Google Scholar 

  • Reggio, H. A., and Dagorn, J. C., 1978, Ionic interactions between bovine chymotrypsinogen A and chondroitin sulfate A. B. C., J. Cell. Biol. 78: 951.

    Article  PubMed  CAS  Google Scholar 

  • Reggio, H., and Palade, G. E., 1976, Sulfated compounds in the secretion and zymogen granule content of the guinea pig pancreas, J. Cell Biol. 70: 360a.

    Google Scholar 

  • Reggio, H. A., and Palade, G. E., 1978, Sulfated compounds in the zymogen granules of the guinea pig pancreas, J. Cell Biol. 77: 288.

    Article  PubMed  CAS  Google Scholar 

  • Ronzio, R. A., Kronquist, K. E., Lewis, D. S., MacDonald, R. J., Mohrlok, S. H., and O’Donnell, J. J., Jr., 1978, Glycoprotein synthesis in the adult rat pancreas. IV. Subcellular distribution of membrane glycoproteins, Biochim. Biophys. Acta 508: 65.

    Article  PubMed  CAS  Google Scholar 

  • Simpson, D. L., Thorne, D. R., and Loh, H. H., 1976, Sulfated glycoproteins, glycolipids, and glycosaminoglycans from synaptic plasma and myelin membranes: Isolation and characterization of sulfated glycopeptides, Biochemistry 15: 5449.

    Article  PubMed  CAS  Google Scholar 

  • Simson, J. A. V., 1977, The influence of fixation on the carbohydrate cytochemistry of rat salivary gland secretory granules, Histochem. J. 9: 645.

    Article  PubMed  CAS  Google Scholar 

  • Slaby, F., and Farquhar, M. G., 1976, The major polypeptides of somatotrophic and mammotrophic granules from the rat anterior pituitary, J. Cell Biol. 70: 92a.

    Google Scholar 

  • Smith, A. D., and Winkler, H., 1967, Purification and properties of an acidic protein from chromaffin granules of bovine adrenal medulla, Biochem. J. 103: 483.

    PubMed  CAS  Google Scholar 

  • Smith, W. J., and Kirshner, N., 1967, A specific soluble protein from the catecholamine storage vesicles of bovine adrenal medulla. I. Purification and chemical characterization, Mol. Pharmacol. 3: 52.

    PubMed  CAS  Google Scholar 

  • Stadler, H., and Whittaker, V. P., 1978, Identification of vesiculin as a glycosaminoglycan, Brain Res. 153: 408.

    Article  PubMed  CAS  Google Scholar 

  • Steinman, R. M., Scott, E. B., and Cohn, Z. A., 1976, Membrane flow during pinocytosis: A stereological analysis, J. Cell Biol. 68: 665.

    Article  PubMed  CAS  Google Scholar 

  • Svensson, H., Elhammer, A., Autuori, F., and Dallner, G., 1976, Biogenesis of microsomal membrane glycoproteins in rat liver. IV. Characteristics of a cytoplasmic lipoprotein having properties of a membrane precursor, Biochim. Biophys. Acta 455: 383.

    Article  PubMed  CAS  Google Scholar 

  • Tartakoff, A., Greene, L. J., and Palade, G. E., 1974, Studies on the guinea pig pancreas: Fractionation and partial characterization of exocrine proteins, J. Biol. Chem. 249: 7420.

    PubMed  CAS  Google Scholar 

  • Tasso, F., 1973, Localisation cytochimique ultrastructurale de glycoproteins dans les granules neurosecretoires de la post-hypophyse du rat, J. Microsc. 18: 115.

    CAS  Google Scholar 

  • Tasso, F., Rua, S., and Picard, D., 1977, Cytochemical duality of neurosecretory material in the hypothalamo-posthypophysial system of the rat as related to hormonal content, Cell Tissue Res. 180: 11.

    Article  PubMed  CAS  Google Scholar 

  • Uvnas, B., 1974, The molecular basis for the storage and release of histamine in rat mast cell granules. Life Sci. 14: 2355.

    Article  PubMed  CAS  Google Scholar 

  • Vilhardt, H., Baker, R. V., and Hope, D. B., 1975, Isolation and protein composition of membranes of neurosecretory vesicles and plasma membranes from the neural lobe of the bovine pituitary gland, Biochem. J. 148: 57.

    PubMed  CAS  Google Scholar 

  • Vos, J., Kuriyama, K., and Roberts, E., 1969, Distribution of acid mucopolysaccharides in subcellular fractions of mouse brain, Brain Res. 12: 172.

    Article  PubMed  CAS  Google Scholar 

  • Wallace, E. F., Krantz, M. J., and Lovenberg, W., 1973, Dopamine /hydroxylase: A tetrameric glycoprotein, Proc. Natl. Acad. Sci. U.S.A. 70: 2253.

    Article  PubMed  CAS  Google Scholar 

  • Wallach, D., and Schramm, M., 1971, Calcium and the exportable protein in rat parotid gland: Parallel subcellular distribution and concomitant secretion, Eur. J. Biochem. 21: 433.

    Article  PubMed  CAS  Google Scholar 

  • Wallach, D., Kirshner, N., and Schramm, M., 1975, Non-parallel transport of membrane proteins and content proteins during assembly of the secretory granule in rat parotid gland, Biochim. Biophys. Acta 375: 87.

    Article  PubMed  CAS  Google Scholar 

  • Winkler, H., 1976, The composition of adrenal chromaffin granules: An assessment of controversial results, Neuroscience 1: 65.

    Article  PubMed  CAS  Google Scholar 

  • Winkler, H., 1977, The biogenesis of adrenal chromaffin granules, Neuroscience 2: 657.

    Article  PubMed  CAS  Google Scholar 

  • Winkler, H., Schneider, F. H., Rufener, C., Nakane, P. K., and Hortnagl, H., 1974, Membranes of adrenal medulla: Their role in exocytosis, in: Cytopharmacology of Secretion ( B. Ceccarelli, F. Clementi, and J. Meldolesi, eds.), pp. 127–139, Raven Press, New York.

    Google Scholar 

  • Zanini, A., and Giannattasio, G., 1973, Isolation of prolactin granules from rat anterior pituitary glands, Endocrinology 92: 349.

    Article  PubMed  CAS  Google Scholar 

  • Zanini, A., Giannattasio, G., and Meldolesi, J., 1979A, Intracellular events in prolactin secretion, in: Synthesis and Release of Adenohypophyseal Hormones (M. Jutisz and K. McKerns, eds.), Plenum Press, New York (in press).

    Google Scholar 

  • Zanini, A., Giannattasio, G., Margolis, R. K., Margolis, R. U., Nussdorfer, G., and Meldolesi, J., 19796, Molecular organization of prolactin granules. II. Characterization of glycosaminoglycans and glycoproteins of bovine prolactin granule matrix (in prep.).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology and CNR Center of Cytopharmacology, University of Milan, Milan, Italy

    Giuliana Giannattasio, Antonia Zanini & Jacopo Meldolesi

Authors
  1. Giuliana Giannattasio
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Antonia Zanini
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jacopo Meldolesi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. New York University Medical Center, New York, New York, USA

    Richard U. Margolis

  2. Downstate Medical Center, State University of New York, Brooklyn, New York, USA

    Renée K. Margolis

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Plenum Press, New York

About this chapter

Cite this chapter

Giannattasio, G., Zanini, A., Meldolesi, J. (1979). Complex Carbohydrates of Secretory Organelles. In: Margolis, R.U., Margolis, R.K. (eds) Complex Carbohydrates of Nervous Tissue. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2925-1_15

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2925-1_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-2927-5

  • Online ISBN: 978-1-4613-2925-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation