Abstract
Over the last few years, considerable attention has been devoted to the role played by complex carbohydrates in the structure and function of secretory granules and vesicles. These intracellular storage organelles, which are delimited by a single membrane, are endowed with the ability to discharge their content into the extracellular space by exocytosis. Since each secretory system is characterized by the specificity of its secretion products, the various granules and vesicles constitute an extremely heterogenous family of organelles. In some of them, complex carbohydrates represent secretion products of known physiological significance. This is the case, for instance, with the gonadotropin and thyrotropin granules of the anterior pituitary, the B granules of follicular thyroid cells, and the immunoglobulin vesicles of plasmocytes. Other secretory granules (e.g., those of the exocrine pancreas, parotid gland, and liver) contain a mixture of many physiologically important secretion products, some of which are complex carbohydrates. Finally, in a variety of other systems, the occurrence of complex carbohydrates (often in small amounts) in the segregated content of secretory organelles has also been reported, even if no clear information is yet available on whether these components have any function after their discharge. However, complex carbohydrates do not reside only in the content of secretory organelles, since in all systems so far investigated they have also been found in the limiting membrane, where at least some of them are oriented according to a specific geometry.
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Giannattasio, G., Zanini, A., Meldolesi, J. (1979). Complex Carbohydrates of Secretory Organelles. In: Margolis, R.U., Margolis, R.K. (eds) Complex Carbohydrates of Nervous Tissue. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2925-1_15
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