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Acute Renal Failure pp 167–175Cite as

Endocrine System in Acute Renal Failure

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Abstract

Occurrence of endocrine abnormalities in acute renal failure (ARF) may be expected for the following reasons: (a) The kidney is an important endocrine organ, in which erythropoietin angiotensin I and II, active vitamin D metabolites, kinins, and prostaglandins are synthesized. (b) The kidney is an important excretory and biodegrading organ for hormones. (c) The kidney is the target organ of several hormones involved in the regulation of its excretory and endocrine functions. (d) ARF is caused by different etiological factors or is accompanied by deep alterations of the internal environment, which per se may influence secretion control of hormones, their transport, transformation, degradation, and binding to target cells.

Keywords

  • Acute Renal Failure
  • Leydig Cell
  • Plasma Renin Activity
  • Basal Plasma
  • Plasma Prolactin

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Hollenberg NK, Adams DF, Oken DE, Abrams HL, Merrill JPT. Acute renal failure due to nephrotoxins. Renal hemodynamic and angiographic studies in man. N Engl J Med 282: 1329–1334, 1970.

    PubMed  CrossRef  CAS  Google Scholar 

  2. Hollenberg NK, Epstein M, Rosen SM, Basch RI, Oken DE, Merrill JP. Acute renal failure in men. Evidence for preferential renal cortisol ischemia. Medicine 47: 455–474, 1968.

    PubMed  CrossRef  CAS  Google Scholar 

  3. Hollenberg NK, Sandor T, Controy M, Adams DS, Solomon HS, Abrams HL, Merrill JP. The transit of radioxenon through the oliguric human kidney: Analysis by the method of maximum likelihood. Kidney Int 3: 177–185, 1973.

    PubMed  CrossRef  CAS  Google Scholar 

  4. Reubi FC, Vorburger C. Renal hemodynamics in acute renal failure after shock in man. Kidney Int 10: S137–S143, 1976.

    Google Scholar 

  5. Börner H, Klinkmann H. Pathogenesis of acute noninflammatory renal failure. Nephron 25: 261–266, 1980.

    PubMed  CrossRef  Google Scholar 

  6. Kokot F. Die Pathophysiologie des akuten, nichtentzündlichen Nierenversagens. Z Ges Inn Med 33: 329–335, 1978.

    PubMed  CAS  Google Scholar 

  7. Levinsky NG. Pathophysiology of acute renal failure. N Engl J Med 296: 1453–1458, 1977.

    PubMed  CrossRef  CAS  Google Scholar 

  8. Kokot F, Kuska J. Influence of extracorporeal dialysis on insulin-induced human growth hormone secretion in patients with acute renal failure. Nephron 12: 241–248, 1974.

    PubMed  CrossRef  CAS  Google Scholar 

  9. Pimstone BL, Le Roith D, Epstein S, Kronheim S. Disappearance rates of plasma growth hormone after intravenous somatostatin in renal and liver diseases. J Clin Endocrinol Metab 41: 392–395, 1975.

    PubMed  CrossRef  CAS  Google Scholar 

  10. Levitan D. Human and animal studies of the function of hypothalamic-pituitary-gonadal (H-P-G) axis during acute renal failure. In Acute Renal Failure, Eliahou HE (ed). London: John Libbey, 1982, p. 301.

    Google Scholar 

  11. Massry SG, Goldstein DA, Procci WR, Kletzky OA. On the pathogenesis of sexual dysfunction of the uremic male. Proc EDTA 17: 139–145, 1980.

    CAS  Google Scholar 

  12. Kokot F, Kuska J. Influence of hemodialysis in glucose utilization and insulin secretion in patients with acute renal failure. Eur J Clin Invest 3: 105–111, 1973.

    PubMed  CrossRef  CAS  Google Scholar 

  13. Sagild U. Glucose tolerance in acute renal failure. Acta Med Scand 172: 405–411, 1962.

    PubMed  CrossRef  CAS  Google Scholar 

  14. Henneman PH, Forbes AP, Moldawer M, Dempsey EF, Caroll EL. Effects of human growth hormone in man. J Clin Invest 39: 1223–1238, 1960.

    PubMed  CrossRef  CAS  Google Scholar 

  15. Eskildsen PC, Sørenson OH, Bishop JE, Norman AW. Acromegaly and vitamin D metabolism: Effect of bromocriptine treatment. J Clin Endocrinol Metab 49: 484–486, 1979.

    PubMed  CrossRef  CAS  Google Scholar 

  16. Spanos E, Barett D, MacIntyre I, Pike JW, Safilian EF, Haussler MR. Effect of growth hormone on vitamin D metabolism. Nature 273: 246–247, 1978.

    PubMed  CrossRef  CAS  Google Scholar 

  17. Grzeszczak W, Kokot F, Dulawa J. Prolactin secretion in patients with acute chronic renal failure. Arch Immunol Ther Exp (in press).

    Google Scholar 

  18. Kokot F, Mleczko A, Pazera A. Parathyroid hormone and prolactin and function of the pituitary gonadal axis in male patients with acute renal failure. Kidney Int (in press).

    Google Scholar 

  19. Levitan D, Moser S, Goldstein DA, Kletzky O, Massry SG. Disturbances in the function of the hypothalamic-pituitary gonadal (H-P-G) axis during acute renal failure in the male. Kidney Int 19: 131, 1981.

    Google Scholar 

  20. Ferland L, Kabris F, Kelly PA, Raymond V. Interactions between hypothalamic and peripheral hormones in the control of prolactin secretion. Fed Proc 39: 2917–2920, 1980.

    PubMed  CAS  Google Scholar 

  21. Isaac R, Merceron RE, Caillens G, Raymond JP, Ardaillou R. Effect of parathyroid hormone on plasma prolactin in man. J Clin Endocrinol Metab 47: 18–23, 1978.

    PubMed  CrossRef  CAS  Google Scholar 

  22. Dobbie JW, Mountjoy D, Cowden EA, Allison MEM, Ratcliffe JG. Prolactin status in experimentally induced acute renal failure in the rat. Nephron 27: 316–319, 1981.

    PubMed  CrossRef  CAS  Google Scholar 

  23. Spanos E, Colston KW, Evans IMS, Galante LS, McAuley SJ, McIntyre I. Effect of prolactin on vitamin D metabolism. Mol Cell Endocrinol 5: 163–167, 1967.

    CrossRef  Google Scholar 

  24. Kokot F. The endocrine system in patients with acute renal failure. Proc EDTA 18: 617–629, 1981.

    CAS  Google Scholar 

  25. Horky K, Sramkova J, Lachmanova, Tomasek R, Dvorakowa J. Plasma concentrations of antidiuretic hormone in patients with chronic renal insufficiency on maintenance dialysis. Horm Metab Res 11: 241–246, 1979.

    PubMed  CrossRef  CAS  Google Scholar 

  26. Massani ZM, Finkielman S, Worcel M, Agrest A, Paladini AC. Angiotensin blood levels in hypertensive and nonhypertensive diseases. Clin Sci 30: 473–483, 1966.

    PubMed  CAS  Google Scholar 

  27. Ochoa E, Finkielman S, Agrest A. Angiotensin blood levels during the evolution of acute renal failure. Clin Sci 38: 225–231, 1970.

    PubMed  CAS  Google Scholar 

  28. Paton AM, Lever AF, Cliver NWJ, Medina A, Briggs JD, Morton JJ, Brown JJ, Robertson JIS, Fraser R, Tree M, Gavras H. Plasma angiotensin II, renin substrate and aldosterone concentrations in acute renal failure in man. Clin Nephrol 3: 18–23, 1975.

    PubMed  CAS  Google Scholar 

  29. Wong PY, Talamo RC, Wiliams GH. Kallikreinkinin and renin-angiotensin systems in functional renal failure of cirrhosis of the liver. Gastroenterology 73: 1114–1118, 1977.

    PubMed  CAS  Google Scholar 

  30. Hofbauer KG, Konrads A, Bauereiss K, Möhring J, Gross F. Vasopressin and renin in glycerol-induced acute renal failure in the rat. Circ Res 41: 424–428, 1977.

    PubMed  CAS  Google Scholar 

  31. Iaina A, Omdorff M, Gaveno S, Solomon S. ADH effect in development of ischemic acute renal failure. Proc Soc Exp Biol Med 163: 206–211, 1980.

    PubMed  CAS  Google Scholar 

  32. Bodziony D, Kokot F, Czekalski S. Thyroid function in patients with acute renal failure. Intern Urol Nephrol 13: 81–88, 1981.

    CrossRef  CAS  Google Scholar 

  33. Kapstein EM, Levitan D, Feinstein EI, Nicoloff JT, Massry SG. Thyroid hormone indices in acute renal failure. Kidney Int 19: 129, 1981.

    Google Scholar 

  34. Czekalski S, Burton ST, Malczewska E, Kosowicz J, Baczyk K. Comparison of serum levels of thyroid hormones T4, T3, rT3 in dialyzed and nondialyzed uremics. Proceeding of the Second Int Congress for Artificial Organs, New York City, 1981, pp. 98-100.

    Google Scholar 

  35. Gomez-Pan A, Alvarez-Ude F, Yeo PPB, Hall R, Evered DC, Kerr DNS. Function of the hypothalamo-hypophysial-thyroid axis in chronic renal failure. Clin Endocrinol 11: 567–574, 1979.

    CrossRef  CAS  Google Scholar 

  36. Lim VS, Tang VS, Katz A, Refetoff S. Thyroid dysfunction in chronic renal failure. J Clin Invest 60: 522–534, 1977.

    PubMed  CrossRef  CAS  Google Scholar 

  37. Spector DA, Davis PJ, Helderman JH, Bell B, Utiger RD. Thyroid function and metabolic state in chronic renal failure. Ann Intern Med 85: 724–730, 1976.

    PubMed  CAS  Google Scholar 

  38. Weissel M, Stummvoll MK, Wolf A, Fritzsche H. Thyroid hormone in chronic renal failure. Ann Intern Med 86: 664–665, 1977.

    PubMed  CAS  Google Scholar 

  39. Bravermann LE, Vagenakis AG. The thyroid. Clin Endocrinol Metab 8: 621–639, 1979.

    CrossRef  Google Scholar 

  40. Black AMS. Calcium, phosphate and parathyroid disturbances in acute renal failure. Anaesth Intensive Care 6: 342–349, 1978.

    PubMed  CAS  Google Scholar 

  41. Fuss M, Bagon J, Dupont E, Manderlier T, Brauman H, Corvilain J. Parathyroid hormone and calcium blood levels in acute renal failure. With special reference to one patients developing transient hypercalcemia. Nephron 20: 196–202, 1978.

    PubMed  CrossRef  CAS  Google Scholar 

  42. Fuss M, Bergans A, Geurts J, Brauman H, Corvilain J. Effect of rapid variation of renal function on plasma calcitonin and parathyroid hormone in man. Acta Endocrinol 92: 130–137, 1979.

    PubMed  CAS  Google Scholar 

  43. Kokot F, Kuska J. Influence of extracorporeal dialysis on parathyroid hormone secretion in patients with acute renal failure. Nephron 16: 302–309, 1976.

    PubMed  CrossRef  CAS  Google Scholar 

  44. Kovithavongs T, Becker FO, Ing TS. Parathyroid hyperfunction in acute renal failure. Serial studies in man. Nephron 9: 349–255, 1972.

    PubMed  CrossRef  CAS  Google Scholar 

  45. Llach F, Felsenfeld AJ, Haussler MR. The pathophysiology of altered calcium metabolism in rhab-domyolysis-induced acute renal failure. Interactions of parathyroid hormone 25-hydroxycholecalciferol and 1,25-dihydroxycholecalciferol. N Engl J Med 305: 117–123, 1981.

    PubMed  CrossRef  CAS  Google Scholar 

  46. Massry SG, Arieff AI, Coburn JW, Palmieri G, Kleeman CR. Divalent ion metabolism in patients with acute renal failure: Studies on the mechanism of hypocalcemia. Kidney Int 5: 437–445, 1974.

    PubMed  CrossRef  CAS  Google Scholar 

  47. Pietrek J, Kokot F, Kuska J. Kinetics of serum 25-hydroxyvitamin D in patients with acute renal failure. Am J Nutr 31: 1919–1926, 1978.

    CAS  Google Scholar 

  48. Pietrek J, Kokot F, Kuska J. Serum 25-hydroxyvitamin D and parathyroid hormone in patients with acute renal failure. Kidney Int 13: 178–185, 1978.

    PubMed  CrossRef  CAS  Google Scholar 

  49. Turbkington RW, Deicher HK, Neelon PA. Hypercalcemia following acute renal failure. J Clin Endocrinol 28: 1224–1226, 1964.

    CrossRef  Google Scholar 

  50. Leonard CD, Eichner ER. Acute renal failure and transient hypercalcemia in idiopathic rhabdomyolysis. J Am Med Assoc 211: 1539–1540, 1970.

    CrossRef  CAS  Google Scholar 

  51. Weinstein RS, Rudson JB. Parathyroid hormone and 25-hydroxycholecalciferol levels in hypercalcemia of acute renal failure. Arch Intern Med 140: 410–411, 1980.

    PubMed  CrossRef  CAS  Google Scholar 

  52. Wu BC, Pillary VKG, Hawker CD, Armbruster KFW, Shapiro MS, Ing TS. Hypercalcemia in acute renal failure of acute alcoholic rhabdomyolysis. South Afr J 46: 1631–1633, 1972.

    CAS  Google Scholar 

  53. De Torrente A, Berl T, Cohn PD, Kawamoto E, Hertz P, Schrier RW. Hypercalcemia of acute renal failure. Clinical significance and pathogenesis. Am J Med 61: 119–123, 1976.

    PubMed  CrossRef  Google Scholar 

  54. Kokot F, Kuska J, Sledzinski Z, Pietrek J, Baczynski R. Serum calcitonin levels in patients with acute renal failure. Water Mineral Metab 4: 43–48, 1980.

    Google Scholar 

  55. Sommerville PJ, Kaye M. Evidence that resistance to the calcemic action of parathyroid hormone in rats with acute uremia is caused by phosphate retention. Kidney Int 16: 552–560, 1979.

    CrossRef  Google Scholar 

  56. Sommerville PJ, Kaye M. Resistance to parathyroid hormone in renal failure: Role of vitamin D metabolites. Kidney Int 14: 245–254, 1978.

    CrossRef  Google Scholar 

  57. Massry SG, Stein R, Garty J, Arieff AI, Coburn JW, Normann AW, Friedler RM. Skeletal resistance to the calcemic action of parathyroid hormone in uremia: Role of 1,25(OH)2D2. Kidney Int 9: 467–474, 1976.

    PubMed  CrossRef  CAS  Google Scholar 

  58. Ølgaard K, Schwartz J, Finco D, Martin K, Korkor A, Font EB, Arbelaez M, Klahr S, Slatopolsky E. The extraction of PTH (1–34) and the generation of cAMP by isolated perfused bones from acutely uremic dogs. Kidney Int 19: 210, 1981.

    Google Scholar 

  59. Gautvik KM, Tashjian AH Jr. Effects of cations and colchicine on the release of prolactin and growth hormone by functional pituitary tumor cells in culture. Endocrinology 93: 793–799, 1979.

    CrossRef  Google Scholar 

  60. Ardaillou R, Beaufils M, Nivez M-P, Isaac R, Mayard C, Sraer J-D. Increased plasma calcitonin in early acute renal failure. Clin Sci Mol Med 49: 301–304, 1975.

    PubMed  CAS  Google Scholar 

  61. Kokot F, Kuska J, Mleczko Z, Szczechowska E, Pazera A. Uber die Beziehung zwischen Gastrin-und Kalzitonin-Sekretion bei Kranken mit akuter und chronischer Niereninsuffizienz. Dtsch Gesundh-Wesen 36: 429–432, 1981.

    Google Scholar 

  62. Heynen G, Franchimont P. Human calcitonin and serum phosphate. Lancet I: 267, 1974.

    Google Scholar 

  63. Hennesy JF, Gray TK, Cooper CW, Ontjes DA. Stimulation of thyrocalcitonin by pentagastrin and calcium in two patients with medullary carcinoma of the thyroid. J Clin Endocrinol Metab 36: 200–203, 1973.

    CrossRef  Google Scholar 

  64. Melvin KEW, Voelkel EF, Tashjian AH Jr: Medullary carcinoma of the thyroid: Stimulation by calcium and glucagon of calcitonin secretion. In Taylor and Foster, Calcitonin 1969, Proc 2nd Int Symp, London, Heineman Medical, 1969, pp. 487-496.

    Google Scholar 

  65. Dulawa J, Kokot F, Grzeszczak W. Function of the adrenal cortex in acute renal failure (in press).

    Google Scholar 

  66. Brown JJ, Gleadle RI, Lawson DH, Lever AF, Linton AL, Mac Adam RF, Prentice E, Robertson JIS, Tree M. Renin and acute renal failure: Studies in man. Br Med J 1: 253–258, 1970.

    PubMed  CrossRef  Google Scholar 

  67. Kokot F, Kuska J. Plasma renin activity in acute renal insufficiency. Nephron 6: 115–127, 1969.

    PubMed  CrossRef  CAS  Google Scholar 

  68. Kokot F, Kuska J. Plasma renin activity in patients with acute and chronic renal insufficiency treated by hemodialysis. Proc. EDTA 8: 542–545, 1971.

    Google Scholar 

  69. Kokot F, Kuska J. Die Aldosteronämie bei Kranken mit akuter Niereninsuffizienz. Z Ges Inn Med 31: 144–148, 1976.

    PubMed  CAS  Google Scholar 

  70. Mydlik M, Langos, Novotny J, Blazicek P, Derzsiova K, Takac M. Plasmaticka reninova aktivita pri akutnej oblickovej nedostatocnosti. Vnitr Lek 24: 1–10, 1978.

    PubMed  CAS  Google Scholar 

  71. Schröder E, Herms W, Wetzeis E, Dume T, Grabensee B. Plasma-Renin bei akuter und chronischer Niereninsuffizienz und Hämodialyse. Dtsch Med Wochenschr 94: 2262–2267, 1967.

    CrossRef  Google Scholar 

  72. Stone RA, Tisher CC, Hawkins HK, Robinson RR. Juxtaglomerular hyperplasia and hyperreninemia in progressive systemic sclerosis complicated by acute renal failure. Am J Med 56: 119–123, 1974.

    PubMed  CrossRef  CAS  Google Scholar 

  73. Tu WH. Plasma renin activity in acute tubular necrosis and other renal disease with hypertension. Circulation 31: 686–695, 1965.

    PubMed  CAS  Google Scholar 

  74. Blachley JD, Henrich WL. The diagnosis and management of acute renal failure. Semin Nephrol 1: 11–19, 1981.

    Google Scholar 

  75. Kleinknecht D. Donnes recentes sur la physipathologie des nephrites tubulares aique. Pathol Biol (Paris) 29: 197–205, 1980.

    Google Scholar 

  76. Schrier RW, Burke TJ, Conger JD, Arnold PE. Newer aspect of acute renal failure. Proc 8th Int Congr Nephrol Athens, 1981 pp 63-69.

    Google Scholar 

  77. Stein JH, Patak RV, Lifschitz MD. Acute renal failure: Clinical aspects and pathophysiology. Contrib Nephrol 14: 118–141, 1978.

    PubMed  CAS  Google Scholar 

  78. Thurau K, Boylan JW, Mason J. Pathophysiology of acute renal failure. In Renal Disease, Black D, Jones NF (eds). Oxford; Blackwell Scientific Publication, 1979, pp. 64–92a.

    Google Scholar 

  79. Birkhäuser M, Riondel A, Valloton MB. Bromocriptine-induced modulation of plasma aldosterone response to acute stimulation. Acta Endocrinol 91: 294–302, 1979.

    PubMed  Google Scholar 

  80. Bilbrey GL, Faloona GR, White MG, Knochel JP, Borroto J. Hyperglucagonemia in renal failure. J Clin Invest 53: 841–847, 1974.

    PubMed  CrossRef  CAS  Google Scholar 

  81. Dent RI, Hirsch, James JH, Fischer JE. Hypergastrinemia in patients with acute renal failure. Surg Forum 23: 312–313, 1972.

    PubMed  CAS  Google Scholar 

  82. Falcao NA, Wesdorf RIC, Fischer JE. Gastrin levels and gastric acid secretion in anephric patients and in patients with chronic and acute renal failure. J Surg Research 18: 107–111, 1975.

    CrossRef  CAS  Google Scholar 

  83. Kokot F, Król Z, Makowski C, Bodziony D. Serumgastrin bei Patienten mit akuten Nierenversagen. Z Ges Inn Med 34: 753–755, 1979.

    PubMed  CAS  Google Scholar 

  84. Kuska J, Kokot F, Gerlach J. Zachowanie sie gastrynemii po stymulacji jonami wapnia u chorych z ostra i przewlekła niewydolnościa nerek. Pol Arch Med Wewn 63: 149–155, 1980.

    PubMed  CAS  Google Scholar 

  85. Davidson WO, Moore TC, Shipey W, Convaloff AJ. Effect of bilateral nephrectomy and bilateral ureteral ligation on serum gastrin levels in the rat. Gastroenterology 66: 522–525, 1974.

    PubMed  CAS  Google Scholar 

  86. Oken DE. Role of prostaglandins in the pathogenesis of acute renal failure. Lancet 1: 1319–1322, 1975.

    PubMed  CrossRef  CAS  Google Scholar 

  87. Vincenti F, Goldberg LI. Combined use of dopamine and prostaglandin A1 in patients with acute renal failure and hepatorenal syndrome. Prostaglandins 15: 463–472, 1978.

    PubMed  CrossRef  CAS  Google Scholar 

  88. Mauk RH, Patak RV, Fadem SZ, Lifschitz MF, Stein JH. Effect of prostaglandin E administration in a nephrotoxic and a vasoconstrictor model of acute renal failure. Kidney Int 12: 122–130, 1977.

    PubMed  CrossRef  CAS  Google Scholar 

  89. Robinson PJA, Gaunt A, Leung WK, Ima G, McLachlan MSF. Failure of prostaglandin A1 to modify renal diatrizoate uptake in experimental acute renal failure. Invest Radiol 13: 150–154, 1978.

    PubMed  CrossRef  CAS  Google Scholar 

  90. Henrick WL, Blachley JD. Acute renal failure with prostaglandin inhibitors. Semin Nephrol 1: 57–60, 1981.

    Google Scholar 

  91. Morrison AR, Thornton F. Thromboxane A2-major prostaglandin of human hydro-nephrotic kidney. Kidney Int 19: 224, 1981.

    CrossRef  Google Scholar 

  92. Agranenko VA, Komarov LS, Chizhova AI. Erythropoietin and ceruloplasmin in acute renal insufficiency (in Russian). Ter Arkh 40: 77–81, 1968.

    PubMed  CAS  Google Scholar 

  93. Wong PY, Talamo RC, Wiliams GH, Colman RW. Response of kallikrein-kinin and renin-angiotensin systems to saline infusion and upright posture. J Clin Invest 55: 691–698, 1975.

    PubMed  CrossRef  CAS  Google Scholar 

  94. Nasjletti A, Malik KU. Renal kinin-prostaglandin relationship implications for renal function. Kidney Int 19: 860–868, 1981.

    PubMed  CrossRef  CAS  Google Scholar 

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  1. Franciszek Kokot
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    Kokot, F. (1984). Endocrine System in Acute Renal Failure. In: Andreucci, V.E. (eds) Acute Renal Failure. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2841-4_5

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