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Vitamin D pp 721–745Cite as

Resistance to Vitamin D

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Abstract

The recognition and isolation of vitamin D and the prevention of vitamin D nutritional deficiency was an early and major accomplishment in the field of public health. As a result, in many nations rickets and osteomalacia are now uncommon medical problems. In 1937 Fuller Albright and his coworkers reported a patient with rickets (in the absence of renal failure or malabsorption) that was not cured by supraphysiologic doses of vitamin D (1). They recognized that the patient showed resistance to vitamin D; this was the first published report of disease caused by resistance to a vitamin or hormone in man. Albright’s patient with vitamin D resistant rickets probably suffered from x-linked hypophosphatemia (2,3); while hypophosphatemia was persistent, this patient never exhibited the hypocalcemia that is typical of vitamin D deficiency.

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  1. Stephen J. Marx
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  1. Department of Medicine, Mayo Clinic and Foundation, 200 First Street, S.W., Rochester, MN, 55905, USA

    Rajiv Kumar

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Marx, S.J. (1984). Resistance to Vitamin D. In: Kumar, R. (eds) Vitamin D. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2839-1_29

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  • DOI: https://doi.org/10.1007/978-1-4613-2839-1_29

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