Vitamin D pp 69-90 | Cite as

The Metabolism of Dihydroxylated Vitamin D Metabolites

  • R. Kumar


The purpose of this chapter is to describe the metabolism and, in particular, the hepatic and intestinal metabolism of the major dihydroxylated vitamin D metabolites, 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3. A great deal is known about the factors which regulate the synthesis of 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3, but relatively little is known about how these substances are metabolized and what factors control the various metabolic pathways. The metabolism of 1,25-dihydroxyvitamin D3 is of importance as steady state tissue levels of a metabolite are controlled not only by the rate of formation of the metabolite but also by the rate of disposal or degradation. Human and animal experimental data will be presented and the importance of the described metabolic processes in the genesis of hepatic and intestinal osteodystrophy will be discussed.


Primary Biliary Cirrhosis Biliary Excretion Electron Ionization Mass Spectrometry Normal Human Subject Metabolic Clearance Rate 
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© Martinus Nijhoff Publishing, Boston/The Hague/Dordrecht/Lancaster 1984

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  • R. Kumar

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