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Effect of Vitamin D on Cultured Bone Cells

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Vitamin D

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Abstract

The development of current concepts of the importance of vitamin D in the maintenance of calcium homeostasis and normal growth has for the most part come from whole animal studies and clinical observations along with studies on organ culture of bone, kidney and intestine. The use of such systems however is limited by the complexities of the tissues with respect to the presence of differing cell types with unique functions. This is quite apparent in bone tissue, which contains osteoclasts and osteoblasts, their precursor cells, fibroblasts, and chondrocytes in variable amounts depending on the origin of the bone. Resorption and mineralization can be studied in such preparations in vitro, but because of the variety of cell types and the presence of a large volume of extracellular insoluble matrix, it is difficult to identify the cells responsible for the biochemical changes that are observed upon hormone treatment.

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Authors
  1. Robert L. Jilka
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  2. David V. Cohn
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Editors and Affiliations

  1. Department of Medicine, Mayo Clinic and Foundation, 200 First Street, S.W., Rochester, MN, 55905, USA

    Rajiv Kumar

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© 1984 Martinus Nijhoff Publishing, Boston/The Hague/Dordrecht/Lancaster

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Jilka, R.L., Cohn, D.V. (1984). Effect of Vitamin D on Cultured Bone Cells. In: Kumar, R. (eds) Vitamin D. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2839-1_17

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  • DOI: https://doi.org/10.1007/978-1-4613-2839-1_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9793-2

  • Online ISBN: 978-1-4613-2839-1

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