Vitamin D pp 325-341 | Cite as

Induction of Calcium-Binding Protein in Embryonic Chick Duodenum InVitro: Direct Assessment of Biopotency of Vitamin D-Steroids

  • Robert A. Corradino

Abstract

Among several physiologic activities, vitamin D controls the efficiency of intestinal calcium absorption as part of a complex mechanism for maintenance of calcium homeostasis (1). The single most-potent, naturally-occurring vitamin D metabolite (generally considered to be the biologically active form) is 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3). At the molecular level, l,25(OH)2D3 acts similarly to other hormonal steroids (2), in this case with de novo induction of a single new mRNA species coding for a calcium-binding protein (CaBP) in the intestine of vitamin D-deficient rachitic chicks (3,4). CaBP involvement in intestinal calcium absorption in intact chickens is supported by extensive correlative evidence (5).

Keywords

Cholesterol Dexamethasone Alkaloid HEPES Fluorine 

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© Martinus Nijhoff Publishing, Boston/The Hague/Dordrecht/Lancaster 1984

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  • Robert A. Corradino

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