Vitamin D pp 325-341 | Cite as

Induction of Calcium-Binding Protein in Embryonic Chick Duodenum InVitro: Direct Assessment of Biopotency of Vitamin D-Steroids

  • Robert A. Corradino


Among several physiologic activities, vitamin D controls the efficiency of intestinal calcium absorption as part of a complex mechanism for maintenance of calcium homeostasis (1). The single most-potent, naturally-occurring vitamin D metabolite (generally considered to be the biologically active form) is 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3). At the molecular level, l,25(OH)2D3 acts similarly to other hormonal steroids (2), in this case with de novo induction of a single new mRNA species coding for a calcium-binding protein (CaBP) in the intestine of vitamin D-deficient rachitic chicks (3,4). CaBP involvement in intestinal calcium absorption in intact chickens is supported by extensive correlative evidence (5).


Minimal Structure Intestinal Calcium Absorption Organ Culture System Intestinal Receptor Intestinal Mucosal Surface 
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© Martinus Nijhoff Publishing, Boston/The Hague/Dordrecht/Lancaster 1984

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  • Robert A. Corradino

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