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Chemical and Biological Studies of cis — Diamminedichloroplatinum (II) Binding to DNA

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Book cover Platinum Coordination Complexes in Cancer Chemotherapy

Part of the book series: Developments in Oncology ((DION,volume 17))

Abstract

Over a decade has passed since the initial observation that neutral platinum amine coordination compounds with cis configuration of labile groups were effective chemotherapeutic agents.1 Subsequent studies built a strong case that DNA is the relevant biological target of these complexes.2,3 Substantial effort has therefore been directed towards defining and characterizing the interactions of cis-Pt(NH3)2Cl2 (cis-DDP) and the inactive trans-Pt(NH3)2Cl2 (trans-DDP),4 the structures of which are shown in Figure 1, with DNA at the molecular level.

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Authors
  1. J. P. Caradonna
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  2. S. J. Lippard
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Editor information

Editors and Affiliations

  1. Vermont Regional Cancer Center and Department of Pharmacology, University of Vermont, Burlington, Vermont, 05401, USA

    Miles P. Hacker

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© 1984 Martinus Nijhoff Publishing, Boston

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Caradonna, J.P., Lippard, S.J. (1984). Chemical and Biological Studies of cis — Diamminedichloroplatinum (II) Binding to DNA. In: Hacker, M.P., Douple, E.B., Krakoff, I.H. (eds) Platinum Coordination Complexes in Cancer Chemotherapy. Developments in Oncology, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2837-7_3

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  • DOI: https://doi.org/10.1007/978-1-4613-2837-7_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-89838-619-6

  • Online ISBN: 978-1-4613-2837-7

  • eBook Packages: Springer Book Archive

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