Chemical and Biological Studies of cis — Diamminedichloroplatinum (II) Binding to DNA

  • J. P. Caradonna
  • S. J. Lippard
Part of the Developments in Oncology book series (DION, volume 17)


Over a decade has passed since the initial observation that neutral platinum amine coordination compounds with cis configuration of labile groups were effective chemotherapeutic agents.1 Subsequent studies built a strong case that DNA is the relevant biological target of these complexes.2,3 Substantial effort has therefore been directed towards defining and characterizing the interactions of cis-Pt(NH3)2Cl2 (cis-DDP) and the inactive trans-Pt(NH3)2Cl2 (trans-DDP),4 the structures of which are shown in Figure 1, with DNA at the molecular level.


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© Martinus Nijhoff Publishing, Boston 1984

Authors and Affiliations

  • J. P. Caradonna
  • S. J. Lippard

There are no affiliations available

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