Experimental Antitumor Activity of Platinum Coordination Complexes
The search for a “second-generation” Pt compound to supersede cisplatin has been conducted in many laboratories (1–13). For the past six years, the efforts at Bristol-Myers have been focused on finding analogs with improved antitumor activities and reduced toxicities relative to cisplatin as judged by their effects in animal models (1, 10, 11). The present discussion will be limited to a review of antitumor test results obtained with those Pt compounds now undergoing clinical evaluation, and a few other analogs of potential interest.
KeywordsToxicity Platinum Leukemia Titration Cyclohexane
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