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Platelet Transfusion: Quality Control

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Quality Assurance in Blood Banking and Its Clinical Impact

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 7))

Abstract

Platelets for transfusion are prepared either as a byproduct of whole blood donation from multiple donors as platelet concentrates (PC) or using mechanical blood cell separators which prepare large numbers of units form single donors. The available blood cell processors consistently produce platelets of good functional and morphologic quality which are usually administered shortly after collection (1,2,3,4). The major issues of “quality control” relate primarily to proper maintenance and utilization of the machine so as to ensure consistent platelet yields and donor safety. Because all of the available blood cell separators are “open systems”, single donor platelets cannot be stored for more than 24 hours prior to transfusion and long-term storage is therefore not currently a major issue. When such platelet preparations have to be transported long distances under varying conditions of temperature and agitation or when greater than 12 hour storage is contemplated, it is best that the platelets be collected in a large, 2000 ml bag to provide increased surface area for gas exchange (5).

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References

  1. Daly, P.A., Schiffer, C.A., Aisner, J., Wiernik, P.H. A comparison of platelets prepared by the Haemonetics Model 30 and multiunit bag plateletpheresis. Transfusion 1978;19:778–81.

    Article  Google Scholar 

  2. Slichter, S.J. Efficacy of platelets collected by semi-continuous flow centrifugation (Haemonetics Model 30). Brit. J. Haem. 1978;38:131–40.

    Google Scholar 

  3. Katz, A.J., Genco, P.V., Blumberg, N. et al. Platelet collection and transfusion using the Fenwal CS-3000 Cell Separator. Transfusion 1980;21:560–3.

    Article  Google Scholar 

  4. Kalmin, N.D., Grindon, A.J. Pheresis with the IBM 2997. Transfusion 1980;21:325–9.

    Article  Google Scholar 

  5. Katz, A., Houx, J., Ewald, L. Storage of platelets prepared by discontinuous flow centrifugation. Transfusion 1978;18:220–33.

    Article  PubMed  CAS  Google Scholar 

  6. Murphy, S., Gardner, F.H. Platelet storage at 22°C; Metabolic, morphologic, and functional studies. J. Clin. Invest. 1971;50:370–7.

    Article  PubMed  CAS  Google Scholar 

  7. Slichter, S.J., Harker, L.A. Preparation and storage of platelet concentrates. Brit. J. Haem. 1976;34:403–19.

    Article  CAS  Google Scholar 

  8. Pilip, D.J., Aster, R.H. Relative hemostatic effectiveness of human platelets stored at 4° and 22°C. J. Lab. Clin. Med. 1978;91:618–24.

    Google Scholar 

  9. Scott, E.P., Slichter, S.J. Viability and function of platelet concentrates stored in CPD-adenine (CPDA-1). Transfusion 1979;20:489–503.

    Article  Google Scholar 

  10. Murphy, S., Kahn, R.A., Holme, S. et al. Improved storage of platelets for transfusion in a new container. Blood 1982;60:194–200.

    PubMed  CAS  Google Scholar 

  11. Blajchman, M.A., Kelton, J.G., Senyi, A.F. et al. The maintenance of hemostatic function, survival, platelet membrane glycoproteins and pH of human platelet concentrates stored for 5 days in new polyvinyl chloride blood bags. Blood 1981;58:178 (abstract).

    Google Scholar 

  12. Lazarus, H.M., Herzig, R.H., Warm, S.E., Fishman, D.J. Transfusion experience with platelet concentrate stored for 24 to 72 hours at 22°C. Importance of storage time. Transfusion 1982;22:39–43.

    Article  PubMed  CAS  Google Scholar 

  13. Patel, I.P., Ambinder, E., Holland, J.F., Aledort, L.M. In vitro and in vivo comparison of single-donor platelets and multiple-donor pooled platelets transfusions in leukemic patients. Transfusion 1978;18:116–9.

    Article  PubMed  CAS  Google Scholar 

  14. Kahn, R.A., Cossette, I., Friedman, L.I. Optimum centrifugation conditions for the preparation of platelet and plasma products. Transfusion 1976;16:162–5.

    Article  PubMed  CAS  Google Scholar 

  15. Moroff, G., Friedman, A., Robkin-Kline, L. Factors influencing changes in pH during storage of platelet concentrates at 20–24°C. Vox Sang. 1982;42:33–45.

    Article  PubMed  CAS  Google Scholar 

  16. Beutler, E., Kuhl, W. Platelet glycolysis in platelet storage. Transfusion 1980;20:97–100.

    Article  PubMed  CAS  Google Scholar 

  17. Corash, L., Shafter, B., Perlow, M. Heterogeneity of human whole blood platelet subpopulations. I. Relationship between buoyant density, cell volume, and ultrastructure. Blood 1977;49:71.

    PubMed  CAS  Google Scholar 

  18. Mezzano, D., Kwang, K., Aster, R.H. Characteristics of total platelet populations and of platelets isolated in plateletrich plasma. Transfusion 1982;22:197–202.

    Article  PubMed  CAS  Google Scholar 

  19. Slichter, S.J., Harker, L.A. Preparation and storage of platelet concentrates. Brit. J. Haem. 1976;34:395–402.

    Article  CAS  Google Scholar 

  20. Holme, S., Vaidja, K., Murphy, S. Platelet storage at 22°C: Effect of type of agitation on morphology, viability, and function in vitro. Blood 1978;52:425–35.

    PubMed  CAS  Google Scholar 

  21. Holme, S., Murphy, S. Quantitative measurements of platelet shape by light transmission studies; application to storage of platelets for transfusion. J. Lab. Clin. Med. 1978;92:53–64.

    PubMed  CAS  Google Scholar 

  22. Bolin, R.B., Cheney, B.A., Simpliciano, O.A., Smith, D.J. Buoyant density of platelets stored at room temperature as platelet concentrates. J. Lab. Clin. Med. 1981;98:342–51.

    PubMed  CAS  Google Scholar 

  23. Holme, S., Murphy, S. Platelet storage for transfusion at 22°C: Interrelationship of platelet density and size, medium pH, and viability after in vivo infusion. J. Lab. Clin. Med. 1982 (in press).

    Google Scholar 

  24. Slichter, S.J. In vitro measurements of platelet concentrates stored at 4 and 22°C: Correlation with posttransfusion platelet viability and function. Vox Sang. 1981;40:72–86.

    Article  PubMed  Google Scholar 

  25. Moroff, G., Chang, C.H. Aggregation response of human platelets stored at 22°C as platelet-rich plasma. Transfusion 1979;19:704–18.

    Article  PubMed  CAS  Google Scholar 

  26. DiMinno, G., Silver, M., Murphy, S. Stored human platelets retain full aggregation potential in response to pairs of aggregating agents. Blood 1982;59:563–8.

    PubMed  CAS  Google Scholar 

  27. White G.C., Workman, E.F., Lundblad, R.L. The effect of ambient storage on platelet membrane structure and response to thrombin. Transfusion 1979;19:411–9.

    Article  PubMed  Google Scholar 

  28. Jamieson, G.A., Ordinas, A. Surface components of platelets and their changes during storage. Vox Sang. 1981;40:18–21.

    Article  PubMed  Google Scholar 

  29. George, J.N. Platelet membrane glycoproteins: alteration during storage of human platelet concentrates. Thromb. Res. 1976;8:719–24.

    CAS  Google Scholar 

  30. Rao, A.K., Niewiarowski, S., Murphy, S.: Acquired granular pool defect in stored platelets. Blood 1981;57:203–8.

    PubMed  CAS  Google Scholar 

  31. Kotelba-Witkowska, B., Holmsen, H., Murer, E. Storage of human platelets: Effects on metabolicaly active ATP and on release reaction. Br. J. Hematol. 1972;22:429.

    Article  CAS  Google Scholar 

  32. Synder, E.L., Hezzey, A., Katz, A.J., Bock, J. Occurrence of the release reaction during preparation and storage of platelet concentrates. Vox Sang. 1981;41:172–7.

    Article  Google Scholar 

  33. Hamid, M.A., Kunicki, T.J., Aster, R.H. Lipid composition of freshly prepared and stored platelet concentrates. Blood 1980;55:124–30.

    PubMed  CAS  Google Scholar 

  34. Lucas, R.C., Lawrence, J., Stracher, A. On the preservation of contractile proteins during storage of human platelets. Blood 1981;57:1005–10.

    PubMed  CAS  Google Scholar 

  35. Wong, S.C., Rock, G. The effect of adenine on platelet storage. Transfusion 1982;22:283–7.

    Article  PubMed  CAS  Google Scholar 

  36. Kotelba-Witkowska, B., Harmening-Pittiglio, D.M., Schiffer, C.A. Storage of platelet concentrates using ion exchange resin charged with dibasic phosphate. Blood 1981;58:537–43.

    PubMed  CAS  Google Scholar 

  37. Kunicki, T.J., Tuccelli, M., Becker, G.A., Aster, R.H. A study of variables affecting the quality of platelets stored at “room temperature”. Transfusion 1975;15:414.

    Article  PubMed  CAS  Google Scholar 

  38. Kotelba-Witkowska, B., Schiffer, C.A. Cryopreservation of platelet concentrates using glycerol-glucose. Transfusion 1982;22:121–4.

    Article  PubMed  CAS  Google Scholar 

  39. Silver, H., Sonnenwirth, A.C., Beisser, L.D. Bacteriologic study of platelet concentrates prepared and stored without refrigeration. Transfusion 1970;10:315–6.

    Article  PubMed  CAS  Google Scholar 

  40. Buchholz, D.H., Young, V.M., Friedman, N.R. et al. Bacterial proliferation in platelet products stored at room temperature. Transfusion induced Enterobacter sepsis. N. Eng. J. Med. 1971;285–429.

    Google Scholar 

  41. Blajchman, M.A., Thornley, J.H., Richardson, H. et al. Platelet transfusion-induced Serratia Marcescens sepsis due to vacuum tube contamination. Transfusion 1979;19:39–44.

    Article  PubMed  CAS  Google Scholar 

  42. Harker, L.A., Slichter, S.J. The bleeding time as a screening test for the evaluation of platelet function. N. Eng. J. Med. 1972;287:155.

    Article  CAS  Google Scholar 

  43. Daly, P.A., Schiffer, CA., Aisner, J., Wiernik, P.H. Platelet transfusion therapy: One-hour posttransfusion increments are valuable in predicting the need for HLA-matched preparations. JAMA 1980;243:435–8.

    Article  PubMed  CAS  Google Scholar 

  44. Schiffer, C.A. International Forum: What are the parameters to be controlled in platelet concentrates in order that they may be offered to the medical profession as a standardized product with specific properties? Vox Sang. 1981;40:122–4.

    Google Scholar 

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Authors
  1. Ch. A. Schiffer
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Editor information

Editors and Affiliations

  1. Red Cross Blood Bank Groningen-Drenthe, The Netherlands

    C. Th. Smit Sibinga  & P. C. Das  & 

  2. Mayo Clinic Blood Bank, Rochester, MN, USA

    H. F. Taswell

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© 1984 Martinus Nijhoff Publishers, Boston

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Schiffer, C.A. (1984). Platelet Transfusion: Quality Control. In: Sibinga, C.T.S., Das, P.C., Taswell, H.F. (eds) Quality Assurance in Blood Banking and Its Clinical Impact. Developments in Hematology and Immunology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2835-3_18

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  • DOI: https://doi.org/10.1007/978-1-4613-2835-3_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9791-8

  • Online ISBN: 978-1-4613-2835-3

  • eBook Packages: Springer Book Archive

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