Accessory cell function of human endothelial cells: presentation of antigen to T cells

  • Henry Hirschberg
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 27)

Abstract

Recognition of antigen by either in vitro or in vivo primed human T cells requires the participation of some type of Ia positive antigen-presenting cells (for ref. see 1). In rodent and human systems, peripheral blood-derived monocyte/macrophages (MØ), Langerhans epidermal cells, and splenic dendritic cells, all of which carry Ia or Ia-like determinants have shown themselves to be effective accessory cells (2–7). In man, as well as in rodents, gene products of the major histocompatibility complex (HLA) are involved in T cell-accessory cell interaction and activation of sensitized T cells in vitro seems to require co-recognition of self MHC (HLA-D/DR) gene products on the accessory cells together with antigen (8, 9 and 10 for ref.).

Keywords

Collagenase Allo Rubella Concanavalin Ferrone 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Møller, G. (ed.). 1980. Immunological Reviews 53: 1.Google Scholar
  2. 2.
    Møller, G. (ed.). 1978. Immunological Reviews 40: 1.Google Scholar
  3. 3.
    Rosenthal, A.S. et al. 1976. In: Immunobiology of the Macrophage. (Nelson, D.S. ed.). New York, Academic Press, Inc., p. 131.Google Scholar
  4. 4.
    Stingl, G. et al. 1978. J. Immunol. 121: 2005.PubMedGoogle Scholar
  5. 5.
    Braathen, L.R. and Thorsby, E. 1980. Scan. J. Immunol. 11: 401.CrossRefGoogle Scholar
  6. 6.
    Steinman, R.M. and Witmen, D. 1978. Proc. Natl. Acad. Sci. USA 75: 5132.PubMedCrossRefGoogle Scholar
  7. 7.
    Phillips, M.L. et al. 1980. J. Imunol. 124: 2700.Google Scholar
  8. 8.
    Bergholtz, B.O. and Thorsby, E. 1977. Scan. J. Immunol. 6: 779.CrossRefGoogle Scholar
  9. 9.
    Kurnick, J.T. et al. 1980. Scan. J. Immunol. 11: 131.CrossRefGoogle Scholar
  10. 10.
    Thorsby, E. et al. 1982. In: HLA-Typing: Methodology and Clinical Aspectic II. (Ferrone, S. and Solheim, B.G. eds.). CRC-Press 151.Google Scholar
  11. 11.
    Hirschberg, H. et al. 1980. J. Exp. Med. 152: 249.CrossRefGoogle Scholar
  12. 12.
    Hirschberg, H. et al. 1981. Transpl. Proc. XIII: 100.Google Scholar
  13. 13.
    Hirschberg, H. 1981. Human Immunology 2: 235.PubMedCrossRefGoogle Scholar
  14. 14.
    Hirschberg, H. et al. 1981. Scan. J. Immunol. 14: 545.Google Scholar
  15. 15.
    Ashida, E.R. 1981. J. Clin. Invest. 67: 1490.PubMedCrossRefGoogle Scholar
  16. 16.
    Hirschberg, H. et al. 1979. Transplantation 28: 116.PubMedCrossRefGoogle Scholar
  17. 17.
    Hirschberg, H. et al. 1979. Transpl. Proc. XI: 776.Google Scholar
  18. 18.
    Scott, H. et al. 1981. Tissue Antigens 18: 195.PubMedCrossRefGoogle Scholar
  19. 19.
    Gery, J. and Waksman. B.H. 1972. J. Exp. Med. 136: 143.PubMedCrossRefGoogle Scholar
  20. 20.
    Blyden, G. and Handschumacher, R.E. 1977. J. Immunol. 118: 1631.PubMedGoogle Scholar
  21. 21.
    Berger, D. et al. 1981. Human Immunology 3: 209.CrossRefGoogle Scholar
  22. 22.
    Maraes, J.P. and Statsny, P. 1977. J. Clin. Invest. 60: 449.CrossRefGoogle Scholar
  23. 23.
    Paul, L.C. et al. 1979. New Engl. J. Med. 300: 1258.PubMedCrossRefGoogle Scholar
  24. 24.
    Lafferty, K.J. 1980. Transplantation 29: 179.PubMedCrossRefGoogle Scholar
  25. 25.
    Hirschberg, H. and Thorsby, Es. 1981. Transplantation 31: 96.PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers, Boston 1984

Authors and Affiliations

  • Henry Hirschberg

There are no affiliations available

Personalised recommendations