Accessory cell function of human endothelial cells: presentation of antigen to T cells

  • Henry Hirschberg
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 27)


Recognition of antigen by either in vitro or in vivo primed human T cells requires the participation of some type of Ia positive antigen-presenting cells (for ref. see 1). In rodent and human systems, peripheral blood-derived monocyte/macrophages (MØ), Langerhans epidermal cells, and splenic dendritic cells, all of which carry Ia or Ia-like determinants have shown themselves to be effective accessory cells (2–7). In man, as well as in rodents, gene products of the major histocompatibility complex (HLA) are involved in T cell-accessory cell interaction and activation of sensitized T cells in vitro seems to require co-recognition of self MHC (HLA-D/DR) gene products on the accessory cells together with antigen (8, 9 and 10 for ref.).


Endothelial Cell Herpes Simplex Virus Varicella Zoster Virus Purify Protein Derivative Accessory Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Martinus Nijhoff Publishers, Boston 1984

Authors and Affiliations

  • Henry Hirschberg

There are no affiliations available

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