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Ultrastructural Observations in Therapy-Related Panmyelosis

  • Robert W. McKenna
  • Janet L. Parkin
  • Richard D. Brunning
Chapter
Part of the Developments in Oncology Series book series (DION, volume 14)

Abstract

Acute nonlymphocytic leukemia occurring in individuals having received alkylating agent chemotherapy and/or radiotherapy is a well-recognized complication of treatment of hematologic and nonhematologic malignancies and certain nonneoplastic disorders [1–9]. The incidence of acute leukemia in these patients is not well established but appears to be related to the intensity of therapy and age of the patient [10–12]. The interval from the commencement of the treatment of the primary disease to the recognition of the secondary leukemia varies considerably; in the patients studied in this institution it has ranged from 25 to 182 months, with a median interval of 66 months. Response to treatment for the therapy-related leukemias has generally been poor and survival has been shorter than for non-therapy-related acute myelogenous leukemia [13–15].

Keywords

Uranyl Acetate Acute Leukemia Lead Citrate Acute Myelogenous Leukemia Mast Cell Granule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing, Boston/The Hague/Dordrecht/Lancaster 1984

Authors and Affiliations

  • Robert W. McKenna
  • Janet L. Parkin
  • Richard D. Brunning

There are no affiliations available

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