Advertisement

Fine Structure of Leukemic T- and B-Cells, with Special Reference to Adult T-Cell Leukemia in Japan

  • Katasuko Kataoka
  • Yumiko Sakano
  • Nobutaka Imamura
  • Shimeru Kamihira
  • Jun Minowada
Part of the Developments in Oncology Series book series (DION, volume 14)

Summary

The ultrastructure of human T and B leukemic cells is compared in this review. Both cells types can display smooth and villous surfaces, and nuclear pockets. B-cells generally contain more abundant rough endoplasmic reticulum (RER) than T-cells. On the other hand, pre-B-cells have as little RER as T-cells. Clustered dense granules, which exhibit lysosomal enzyme activities, seem to be a reliable ultrastructural marker of T-cells. Accumulation of glycogen particles is seen in T- but not in B-cells. Endoplasmic reticulum- or ribosome-related abnormalities, such as intracisternal accumulation of immunoglobulin, annulate lamellae, and a ribosome-latnella complex, are sometimes found in B-cells.

Ultrastructure of adult T-cell leukemia (ATL) generally conforms with that seen in other T-cell leukemias. It appears that nuclear irregularity and nuclear pocket formation are more prominent in ATL cells, than in other T-cell disorders.

Keywords

Chronic Lymphocytic Leukemia Rough Endoplasmic Reticulum Hairy Cell Leukemia Dense Granule Glycogen Particle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Zuckcr-Franklin D, Greaves MF, Grossi CE, Marmont AM Atlas of blood cells: Function and pathology. Milan: Edi Ermes, 1981, Philadelphia: Lea & Febiger. 1981.Google Scholar
  2. 2.
    Glick A1), Vestal BK, FlexnerJM, Collins RD. Ultrastructural study of acute lymphocytic leukemia: Comparison with immunologic studies. Blood 52: 31 1–322, 1978.Google Scholar
  3. 3.
    McKenna RW, Parkin J, Brunning RD. Morphologic and ultrastructural characteristics of T-cell acute lymphoblastic leukemia. Cancer 44: 1290–1297, 1979.PubMedCrossRefGoogle Scholar
  4. 4.
    SaidJW, Hargreaves UK. Pinkus GS. Non Hodgkin’s lymphomas: An ultrastructural study correlating morphology and immunologic cell type. Cancer 44: 504–528, 1979.CrossRefGoogle Scholar
  5. 5.
    Paracios JJN, Valdcs MD, Pallares MAM. de Salazar MDG. Marcilla AG: Lymphoblastic lymphoma/leukemia of T-cell origin: Ultrastructural. cytochemical and immunologic features of ten cases. Cancer 48: 1982–1991, 1981.CrossRefGoogle Scholar
  6. 6.
    Watanabe Y, Tamaoki N. Habu S. Tashiro Y. Akatsuka S, Enomoto Y. Fine structural study on human T- and B-lymphocytes (in Japanese with English abstract). Acta Haematol Jpn 37: 655–666. 1974.Google Scholar
  7. 7.
    Kataoka K, Minowada J. Human T and B lymphoid cells: An electron microscopic study on thymocytes, peripheral blood lymphocytes, mirogen-stimulated cells and lymphoid cell lines. Arch Histol Jpn 42: 355–374, 1979.PubMedGoogle Scholar
  8. 8.
    Kataoka K. Minowada J. Human leukemic T and B lymphoid cells: Comparison of their ultrastructure. Biomed Res 1: 32 - 41, 1980.Google Scholar
  9. 9.
    Uchiyama T, Broder S. Walsmann TA. A monoclonal antibody (Tac) reactive with activated and functionally mature T cells: 1. Production of anti-Tac monoclonal anti-body and distribution of Tac (+) cells. J Immunol 126: 1393–1397. 1981.PubMedGoogle Scholar
  10. 10.
    Catovsky D. T cell origin of acid phosphatase positive lymphoblasts. Lancct 2: 327–328, 1975.CrossRefGoogle Scholar
  11. 11.
    Ritter J. Gaedicke G, Winkler K, Beckman H, Landbeck G. Possible T-cell origin of lymphoblasts in acid phosphatase positive lymphatic leukemia. Lancet 2: 75, 1975.PubMedCrossRefGoogle Scholar
  12. 12.
    Catovsky D, Cherchi M, Greaves MF, Janossy G. Pain C, Kay HFM. Acid phosphatase reaction in acute lymphoblastic leukemia. Lancet 1: 749–751, 1978.PubMedCrossRefGoogle Scholar
  13. 13.
    Zicca A, Leprini A. Cadoni A. Franzi AT, Ferrarini M, Grossi CE Ultrastructural localization of alpha-naphthyl acid esterase m human TM Ivmphocytes. Am I Pathol 105: 40–46, 1981.Google Scholar
  14. 14.
    Kulenkampff J. Janossy G, Greaves MF. Acid esterase in human lymphoid cells and leukemic blasts: a marker for T lymphocytes. Br J Haematol 36: 231–240, 1977.PubMedCrossRefGoogle Scholar
  15. 15.
    Knowles DM II, Hoffman T, Ferrarini M. Kunkel HG. The demonstration of acid α-naphthyl acetate esterase activity in human lymphoevtes: Usefulness as a T-cell marker. Cell Immunol 35: 112–123, 1978.Google Scholar
  16. 16.
    Grossi CF, Webb SR, Zicca A. Lydyard PM, Moretta L, Mingari MC, Cooper MD. Morphological and histochcmical analyses of two human T-cell subpopulations bearing receptors for IgM or IgG. J Exp Med 147: 1405–1417, 1978.PubMedCrossRefGoogle Scholar
  17. 17.
    Preud’homme J-L, Seligmann M. Surface bound immunoglobulins as a cell marker in human lymphoproliferative disease. Blood 40: 777–794, 1972.PubMedGoogle Scholar
  18. 18.
    Guglielmi P, Preud’homme JL, Gourdin M-F, Reyes F. Daniel M-T. Unusual intracytoplasmic immunoglobulin inclusions in chronic lymphocytic leukaemia. Br J Haematol 50:123–1. 34, 1982.Google Scholar
  19. 19- Katayama I, Schneider GB. Further ultra-structural characterization of hairy cells of leukemic reticuloendotheliosis. Am J Pathol 86:163–182, 197 7.Google Scholar
  20. 20.
    Rosncr MC, Golomb HM. Ribosome-lamella complex in hairy cell leukemia Ultrastructure and distribution. Lab Invest 42: 236–247, 1980.Google Scholar
  21. 21.
    Mirra SS, Miles ML, Jacobs J. The coexistence of ribosome-lamella complex and annulate lamellae in chronic lymphocytic leukemia. Ultrastr Pathol 2: 249–256, 1981.CrossRefGoogle Scholar
  22. 22.
    Sebahoun G. Bayle J, Muratore R. Carcassone V. Ribosome-lamella complex in neoplastic cells of a Sezary’s syndrome. I Clin Pathol 32: 1041–1044, 1979.CrossRefGoogle Scholar
  23. 23.
    Watanabe S. Berard CW, Riche T. Annu¬late lamellae in four cases of diffuse lymphocytic lymphoma. I Natl Cancer Inst 58: 777–780, 1977.Google Scholar
  24. 24.
    Uchiyama T, Yodoi J. Sagawa K.Takatsuki K, Uchino H. Adult T-cell leukemia: Clinical and hematologic features of 16 cases. Blood 50: 481–492, 1977.Google Scholar
  25. 25.
    Hanaoka M, Sasaki M, Matsumoto H, Tankawa H. Yamabe H, Tomimoto K, Tasaka C, Fujiwara H, Uchiyama T. Takatsuki K. Adult T cell leukemia: 1 listological classification and characteristics. Acta Pathol Jpn 29: 723–738. 1979.PubMedGoogle Scholar
  26. 26.
    Tajima K. Tominaga S, Shimizu H. Suchi T. A hypothesis on the etiology of adult T-cell leukemia/lvmphoma. Gann 72: 684–691. 1981.PubMedGoogle Scholar
  27. 27.
    Hinuma Y. Nagata K. Hanaoka M. Nakai M, Matsumoto T, Kinoshita K, Shirakawa S, Miyoshi 1 Adult T-cell leukemia: Antigen in an ATI. cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad So USA 78: 6476–6480, 1981.CrossRefGoogle Scholar
  28. 28.
    Hattori T, Uchiyama T. Toibana T. Takatsuki K, Uchino H. Surface phenotype of Japanese adult T cell leukemia cells characterized by monoclonal antibodies. Blood 58: 645–647, 1981.PubMedGoogle Scholar
  29. 29.
    Shamoto M. Murakami S. Zenke T. Adult T-cell leukemia in Japan: An ultrastructural study. Cancer 47: 1804 - 1811, 1980.Google Scholar
  30. 30.
    EimotoT. Mitsui T. Kikuchi M. Ultrastructure of adult T-cell leukemia/lvmphoma. Virchows Arch [Cell Pathol] 38: 189–208. 1981.CrossRefGoogle Scholar
  31. 31.
    Kotani H. A three dimensional analysis of human peripheral blood leucocytes with scanning electron microscopy: II. A study on the relationship between surface markers and surface morphologies of neoplastic cells from various types of lymphocytic leukemia. Jpn Arch Internal Med 28:221–245, 1981 (in Japanese with English abstract).Google Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston/The Hague/Dordrecht/Lancaster 1984

Authors and Affiliations

  • Katasuko Kataoka
  • Yumiko Sakano
  • Nobutaka Imamura
  • Shimeru Kamihira
  • Jun Minowada

There are no affiliations available

Personalised recommendations