Fine Structure of Leukemic T- and B-Cells, with Special Reference to Adult T-Cell Leukemia in Japan

  • Katasuko Kataoka
  • Yumiko Sakano
  • Nobutaka Imamura
  • Shimeru Kamihira
  • Jun Minowada
Part of the Developments in Oncology Series book series (DION, volume 14)


The ultrastructure of human T and B leukemic cells is compared in this review. Both cells types can display smooth and villous surfaces, and nuclear pockets. B-cells generally contain more abundant rough endoplasmic reticulum (RER) than T-cells. On the other hand, pre-B-cells have as little RER as T-cells. Clustered dense granules, which exhibit lysosomal enzyme activities, seem to be a reliable ultrastructural marker of T-cells. Accumulation of glycogen particles is seen in T- but not in B-cells. Endoplasmic reticulum- or ribosome-related abnormalities, such as intracisternal accumulation of immunoglobulin, annulate lamellae, and a ribosome-latnella complex, are sometimes found in B-cells.

Ultrastructure of adult T-cell leukemia (ATL) generally conforms with that seen in other T-cell leukemias. It appears that nuclear irregularity and nuclear pocket formation are more prominent in ATL cells, than in other T-cell disorders.


Chronic Lymphocytic Leukemia Rough Endoplasmic Reticulum Hairy Cell Leukemia Dense Granule Glycogen Particle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Martinus Nijhoff Publishing, Boston/The Hague/Dordrecht/Lancaster 1984

Authors and Affiliations

  • Katasuko Kataoka
  • Yumiko Sakano
  • Nobutaka Imamura
  • Shimeru Kamihira
  • Jun Minowada

There are no affiliations available

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