Prolymphocytic Leukemia of B- and T-Cell Types

Morphological Differences by Light and Electron Microscopy
  • Daniel Catovsky
  • Estela Matutes
  • Alistair D. Crockard
  • Maureen O’Brien
  • Christine Costello
Part of the Developments in Oncology Series book series (DION, volume 14)


Prolymphocytic leukemia (PLL) is a distinct variant of chronic lymphocytic leukemia (CLL) [1, 2]. Although PLL may be suspected in patients with massive splenomegaly and lymphocyte counts over 100 × 109/1, the diagnosis can be made only by identifying the prolymphocyte as the predominant cell in well-prepared peripheral blood films. The typical morphological features of the prolymphocyte—namely, larger size than a normal blood lymphocyte (or CLL) slightly more cytoplasm, and a prominent nucleolus—are best appreciated at ultrastructural level [1, 3–7].


Chronic Lymphocytic Leukemia Cytoplasmic Granule Large Granule Massive Splenomegaly Fischer Exact Test 
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Copyright information

© Martinus Nijhoff Publishing, Boston/The Hague/Dordrecht/Lancaster 1984

Authors and Affiliations

  • Daniel Catovsky
  • Estela Matutes
  • Alistair D. Crockard
  • Maureen O’Brien
  • Christine Costello

There are no affiliations available

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