Abstract
Prolymphocytic leukemia (PLL) is a distinct variant of chronic lymphocytic leukemia (CLL) [1, 2]. Although PLL may be suspected in patients with massive splenomegaly and lymphocyte counts over 100 × 109/1, the diagnosis can be made only by identifying the prolymphocyte as the predominant cell in well-prepared peripheral blood films. The typical morphological features of the prolymphocyte—namely, larger size than a normal blood lymphocyte (or CLL) slightly more cytoplasm, and a prominent nucleolus—are best appreciated at ultrastructural level [1, 3–7].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Gallon Dag. Goldman JM, Wiltshaw J. Catovsky D. Henry K, Goldcnberg GJ. Prolymphocvtic leukaemia. Br J Haematol 27: 7–23, 1974.
Catovsky D. Prolymphocyte leukaemia. Nouv Rev Fr Hématol, 24: 343–347. 1982.
Costello C, Catovsky D. O’Brien M, Galton DAG. Prolymphocytic leukaemia: An ultrastructural study of 22 cases. Br J Haematol 44: 389–394, 1980.
Costello C. Catovsky D, O’Brien M, Morilla R. Varadi S. Chronic T-cell leukemias: I. Morphology, cytochemistry and ultrastrucrure. Leuk Res 4: 463–476, 1981.
Costello C. Catovsky D. O’Brien M. Cytoplasmic inclusions in a case of prolymphocytic leukemia. Am J Clin Path 76: 499–501, 1981.
Huhn D. Thiel E. Rodt H. Theml H. Prolvmphocytic leukemia. Klin Woch 56: 709–7 14, 1978.
Kjeldsberg CR, Bearman RM, Rappaport H. Prolymphocytic leukemia: An ultrastructural study. Am J Clin Path 73: 150–159, 1980.
Lampert I. Catovsky D. Marsh GW. Child JA. Galton Dag. The histopathology of prolymphocytic leukaemia with particular reference to the spleen: A comparison with chronic lymphocytic leukaemia. Histopath 4: 3–19. 1980.
Catovsky D, Wechsler A, Matutes E. Gomez R, Cherchi M, Pepys EO. Pepys MB, Kitani T, Hoffbrand AV, Greaves MF. The membrane phenotype of T-prolymphocytic leukaemia. Scand 1 Haematol, 29: 398–404, 1982.
Crockard AD, Chalmers D, Matutes E, Catovsky D, Cytochemistry of acid hydrolases in chronic B and T cell leukemias. Am J Clin Path, 78: 437–444, 1982.
Bessis M. Living blood cells and their ultrastructure. Berlin: Springer Verlag, 1973.
Matutes E, Catovsky D. The fine structure of normal lymphocyte subpopularions: A study with monoclonal antibodies and the immunogold technique. Clin Exp Immunol. 50: 416–425, 1982.
Matutes E, Crockard AD. O’Brien M. Catovsky D. Ultrastructural cytochemistry of chronic T-cell leukaemias: A study with four acid hydrolases. Histochem Journal 15: 895–909, 1983.
Bozdech MJ, Bainton DF: Identification of α-naphthyl butyrate esterase as a plasma membrane ectoenzyme of monocytes and as a discrete intracellular membrane bound organelle in lymphocytes. I Exp Med 153: 182–195, 1981.
Catovsky D, Cherchi M. Brooks D. Bradley J. Zola H. Heterogeneity of B-cell leukemias demonstrated by the monoclonal antibody FMC7. Blood 8: 406–408. 1981.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Martinus Nijhoff Publishing, Boston/The Hague/Dordrecht/Lancaster
About this chapter
Cite this chapter
Catovsky, D., Matutes, E., Crockard, A.D., O’Brien, M., Costello, C. (1984). Prolymphocytic Leukemia of B- and T-Cell Types. In: Polliack, A. (eds) Human Leukemias. Developments in Oncology Series, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2823-0_12
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2823-0_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9785-7
Online ISBN: 978-1-4613-2823-0
eBook Packages: Springer Book Archive