Contribution of Cytochemistry in Leukemia

  • Gerassimos A. Pangalis
Part of the Developments in Oncology Series book series (DION, volume 14)


The recognition of subgroups of leukemias by morphologic and cytochemical criteria has greatly contributed over the past decades in the differential diagnosis, classification, and prognosis of the leukemic proliferations [1–13]. In 1964 Hayhoe and his associates [1] in a combined morphologic and cytochemical study of acute leukemias were able to determine four different types of leukemias: acute myeloblastic, acute myelomonocytic, acute lymphoblastic and erythremic myelosis. A few years later Schmalzl and Braunsteiner [14] and Daniel et al. [15] separated the acute monocytic leukemias from the other acute leukemias using the sodium fluoride sensitive naphthol AS-D acetate esterase reaction (NASDA + NaF).


Acute Lymphoblastic Leukemia Acute Leukemia Hairy Cell Leukemia Acute Lymphatic Leukemia Prolymphocytic Leukemia 
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© Martinus Nijhoff Publishing, Boston/The Hague/Dordrecht/Lancaster 1984

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  • Gerassimos A. Pangalis

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