Gossypol pp 237-244 | Cite as

Biochemical Studies of Gossypol

  • Chi-Yu Gregory Lee
  • Young S. Moon
  • Anthony Duleba
  • Albert F. Chen
  • James H. Yuan
  • Victor Gomel
Part of the Reproductive Biology book series (RBIO)

Abstract

Gossypol does indeed prove to be a simple, safe, economical, and reversible method of male contraception, an understanding of its biochemical mechanism of action will be essential, since such elucidation may lead to the development of synthetic compounds exhibiting the desired antifertility effect without the toxicity so far noted in animals and in humans.

Keywords

Sugar Toxicity Lactate Glutathione Citrate 

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References

  1. 1.
    C. Y. Lee and H. V. Mailing, Selective inhibition of lactate dehydrogenase-X by a male antifertility agent-gossypol, Fed. Proc., 40:2790 (1981).Google Scholar
  2. 2.
    C. Y. Lee, Y. S. Moon, J. H. Yuan, and A. F. Chen, Enzyme inactibation and inhibition by gossypol, Mol. Cell. Biochem., Vol. 47, pp. 65–70 (1982).PubMedCrossRefGoogle Scholar
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    C.Y. Lee and H. V. Mailing, 1981, op. cit. (see Ref. 1).Google Scholar
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    H. Pösö, K. Wichmann, J. Jänne, and T. Luukkainen, Gossypol, a powerful inhibitor of human spermatozoal metabolism, Lancet 1: 885 (1980).PubMedCrossRefGoogle Scholar
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    M. B. Abou-Donia, Physiological effect and metabolism of gossypol, Residual Reviews, Vol. 61, p. 126, Springer-Verlag, New York (1976).Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Chi-Yu Gregory Lee
    • 1
  • Young S. Moon
    • 1
  • Anthony Duleba
    • 1
  • Albert F. Chen
    • 1
  • James H. Yuan
    • 1
  • Victor Gomel
    • 1
  1. 1.Department of Obstetrics and GynaecologyThe University of British ColumbiaCanada

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