Biochemical Studies of Gossypol
Gossypol does indeed prove to be a simple, safe, economical, and reversible method of male contraception, an understanding of its biochemical mechanism of action will be essential, since such elucidation may lead to the development of synthetic compounds exhibiting the desired antifertility effect without the toxicity so far noted in animals and in humans.
KeywordsHigh Pressure Liquid Chromatography Male Infertility Enzyme Inactivation Spermatogenic Cell Neutral Aqueous Solution
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- 1.C. Y. Lee and H. V. Mailing, Selective inhibition of lactate dehydrogenase-X by a male antifertility agent-gossypol, Fed. Proc., 40:2790 (1981).Google Scholar
- 3.E. Goldberg, Isozymes in testes and spermatozoa, in: “Isozymes: Current Topics in Biological and Medical Research” (M. C. Rattazzi, J. G. Scandalios, and G. Whitt, eds.), Vol. 1, p. 79, Alan R. Liss, Inc., New York (1977).Google Scholar
- 4.C.Y. Lee and H. V. Mailing, 1981, op. cit. (see Ref. 1).Google Scholar
- 5.Ibid.Google Scholar
- 7.E. Goldberg, 1977, op. cit. (see Ref. 3).Google Scholar
- 10.M. B. Abou-Donia, Physiological effect and metabolism of gossypol, Residual Reviews, Vol. 61, p. 126, Springer-Verlag, New York (1976).Google Scholar