Abstract
Whether one’s perspective is directed toward the effects of high fertility on individual couples or to its impact on nations and the world community, reduced fertility levels are a desirable, even urgent, objective. Some degree of decline in the birth rate can be expected as a consequence of social progress. In many nations and subgroups within nations, however, high fertility itself retards social progress. If fertility could be reduced while other social developments are pursued, a multiplier effect would occur, thus accelerating the overall process. Many nations, particularly in the Third World, have instituted national programs to educate individuals about the personal benefits of fertility regulation and to provide greater access to existing contraceptive methods. Because existing technology has limitations, however, many countries also are encouraging research directed at new and improved techniques for fertility regulation.
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References
M. Briggs and M. Briggs, Oral contraception for men, Nature, 252: 585 (1974).
L. L. Ewig, Effects of testosterone and estradiol, silastic implants, on spermatogenesis in rats and rhesus monkeys, in: “Proceedings Hormonal Control of Male Fertility,” DHEW Publication No. (NIH) 78–1097, p. 173 (1978).
E. M. Coutinho and J. F. Melo, Successful inhibition of spermatogenesis in man without loss of libido: A potential new approach to male contraception, Contraception, 8: 207 (1973).
J. Frick, Control of spermatogenesis in men by combined administration of progestin and androgen, Contraception, 8: 191 (1973).
J. Frick and G. Bartsch, Inhibition of spermatogenesis, in: “Physiology and genetics of reproduction, Part A” (E. M. Coutinho and M. Fuchs, eds.), Plenum Press, New York, p. 230 (1974).
G. R. Cunningham, V. E. Silverman, and P. O. Kohler, Clinical Evaluation of testosterone enanthate for induction and maintenance of reversible azoospermia in man, in: “Proceedings Hormonal Control of Male Fertility,” DHEW Publication No. (NIH) 78–1097, p. 71 (1978a).
C. G. Heller, W. O. Nelson, J. C. Hill, E. Henderson, W. O. Maddock, and E. C. Jung, The effect of testosterone administra tion upon the human testis, J. Clin. Endocrinol. Metab., 10: 816 (1950b).
R. S. Hotchkiss, Effects of massive doses of testosterone propionate upon spermatogenesis, J. Clin. Endocrinol., 4: 117 (1944).
J. Mauss, G. Borsch, E. Richter, and K. Bormacher, Investigations on the use of testosterone enanthate as a male contraceptive agent: a preliminary report, Contraception, 10: 281 (1974).
P. R. K. Reddy and J. M. Rao, Reversible antifertility action of testosterone propionate in human males, Contraception, 5: 295 (1972).
E. Steinberger and K. D. Smith, Testosterone enanthate: a possible reversible male contraceptive, Contraception, 16: 261 (1977a).
J. M. Leonard and C. A. Paulsen, Contraceptive development studies for males: Oral and parenteral steroid hormone administration, in: Proceedings Hormonal Control of Male Fertility, DHEW Publication No. (NIH) 78–1097, p. 223 (1978).
National Coordinating Group on Male Antifertility Agents: Gossypol — a new antifertility agent for males, Chinese Med. J., 4: 417 (1978).
Ibid.
X. R. Wu, Study of antifertility action of cottonseeds and their effective component — gossypol, papers presented at the National Conference on Recent Advances of Family Planning Research, Beijing, March, 1972 and at the First National Conference on Male Antifertility Agents, Wuhan, September, 1972.
J. J. Longmore, Cottonseed oil: Its coloring matter mucilage, and description of a new method of recovering the loss occurring in the refining process, J. Soc. Chem. Ind., 5: 200 (1886).
L. Marchlewski, Gossypol, ein Bestandteil der Baumwollsamen, J. Prakt. Chem., 60: 84 (1899).
National Coordinating Group on Male Antifertility Agents, 1978 op. cit. (see Ref. 13).
N. G. Wang and H. P. Lei, Antifertility effect of gossypol acetic acid on male rats, Natl. Med. J. Clin., 59: 402 (1979).
S. P. Xue, Studies on the antifertility effect of gossypol, a new contraceptive for males, in: “Recent Advances in Fertility Regulation, Proc. Symp. Beijing, September, 1980” ( C. F. Chang, D. Griffin, and A. Wollman, eds.), Atar, Geneva (1983).
Ibid.
X. C. Tang, M. Zhu, and Q. X. Shi, Comparative studies on the absorption, distribution and excretion 14C-gossypol in four species of animals, Acta Pharmacol. Sin., 15: 212 (1980).
National Coordinating Group on Male Infertility Agents, 1978, op. cit. (see Ref. 13).
S. P. Xue, in press, op. cit. (see Ref. 20).
X. C. Tang, et al., 1980, op. cit. (see REf. 22).
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© 1985 Plenum Press, New York
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Segal, S.J. (1985). Introduction and History of Gossypol. In: Segal, S.J. (eds) Gossypol. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2809-4_1
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DOI: https://doi.org/10.1007/978-1-4613-2809-4_1
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