Specificity of Esterases and Effect of Structure of Prodrug Esters of Acylated Acetaminophen on Hydrolytic Reactivity
The transient modification of active drug structures to enhance their efficient delivery is now a widely practiced method (1). Although initial efforts were generally applied to drug substances that had already been introduced, it has become increasingly common for drug developers to incorporate this concept at the earliest stages of development. The art and science of providing a temporary chemical cloak for the active drug species to aid in their delivery is now such a common practice that many, if not most, future drugs will be prodrugs and the term itself may eventually disappear since prodrugs are drugs.
KeywordsPropionate Phen Acetaminophen Cholinesterase Solvolysis
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